MX339910B - Proceso para la separacion mejorada de una solucion organica hidrofobica de un medio de cultivo acuoso. - Google Patents
Proceso para la separacion mejorada de una solucion organica hidrofobica de un medio de cultivo acuoso.Info
- Publication number
- MX339910B MX339910B MX2012015064A MX2012015064A MX339910B MX 339910 B MX339910 B MX 339910B MX 2012015064 A MX2012015064 A MX 2012015064A MX 2012015064 A MX2012015064 A MX 2012015064A MX 339910 B MX339910 B MX 339910B
- Authority
- MX
- Mexico
- Prior art keywords
- culture medium
- aqueous culture
- organic solution
- hydrophobic organic
- active cell
- Prior art date
Links
- 239000001963 growth medium Substances 0.000 title abstract 5
- 230000002209 hydrophobic effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000000926 separation method Methods 0.000 title abstract 2
- 230000003247 decreasing effect Effects 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 239000000758 substrate Substances 0.000 abstract 3
- 230000036983 biotransformation Effects 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 101150071111 FADD gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/99—Oxidoreductases acting on the CH-CH group of donors (1.3) with other acceptors (1.3.99)
- C12Y103/99003—Acyl-CoA dehydrogenase (1.3.99.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
La presente invención se refiere a un proceso para la separación mejorada de una solución orgánica hidrofóbica de un medio de cultivo acuoso, que comprende las etapas de: provisión de un medio de cultivo acuoso que comprende una célula metabólicamente activa, contacto el medio de cultivo acuoso con una solución orgánica hidrofóbica, separación de la solución orgánica hidrofóbica del medio de cultivo acuoso, la célula tiene actividad disminuida, en comparación con su tipo silvestre, por lo menos una enzima que cataliza una de las reacciones de la beta-oxidación de ácidos grasos. La invención es concerniente además con el uso de una célula metabólicamente activa que tiene actividad disminuida, en comparación con su tipo silvestre, de una enzima que cataliza una de las reacciones de la beta-oxidación de ácidos grasos, preferiblemente de una enzima seleccionada del grupo que comprende FadA, FadB, FadO, FadL y FadE, también como variantes de las mismas, más preferiblemente FadE o una variante de la misma, para la separación mejorada de una solución orgánica hidrofóbica de un medio de cultivo acuoso que comprende la célula metabólicamente activa.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11195221.4A EP2607490A1 (de) | 2011-12-22 | 2011-12-22 | Verfahren zur verbesserten Abtrennung einer hydrophoben organischen Lösung von einem wässrigen Kulturmedium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2012015064A MX2012015064A (es) | 2013-10-16 |
| MX339910B true MX339910B (es) | 2016-06-15 |
Family
ID=47351527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012015064A MX339910B (es) | 2011-12-22 | 2012-12-18 | Proceso para la separacion mejorada de una solucion organica hidrofobica de un medio de cultivo acuoso. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9249435B2 (es) |
| EP (3) | EP2607490A1 (es) |
| JP (1) | JP6312117B2 (es) |
| KR (1) | KR102000317B1 (es) |
| CN (2) | CN108358800B (es) |
| BR (1) | BR112014015202B1 (es) |
| CA (1) | CA2799883C (es) |
| ES (1) | ES2688295T3 (es) |
| MX (1) | MX339910B (es) |
| SG (1) | SG11201403495QA (es) |
| WO (1) | WO2013092547A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| UA112980C2 (uk) | 2011-02-16 | 2016-11-25 | Евонік Дегусса Гмбх | Рідкі катіоніти |
| ES2537208T3 (es) | 2011-04-12 | 2015-06-03 | Evonik Degussa Gmbh | Procedimiento realizable continuamente para la preparación de unos compuestos carbonílicos mediante un catalizador que contiene el radical nitroxilo |
| EP2540170A1 (de) | 2011-06-29 | 2013-01-02 | Evonik Degussa GmbH | Dermatologisch wirksamer Hefeextrakt |
| JP6057994B2 (ja) | 2011-07-20 | 2017-01-11 | エボニック デグサ ゲーエムベーハーＥｖｏｎｉｋ Ｄｅｇｕｓｓａ ＧｍｂＨ | 第一級アルコールの酸化及びアミノ化 |
| EP2602328A1 (de) | 2011-12-05 | 2013-06-12 | Evonik Industries AG | Verfahren zur Oxidation von Alkanen unter Verwendung einer AlkB Alkan 1-Monooxygenase |
| EP2607479A1 (en) | 2011-12-22 | 2013-06-26 | Evonik Industries AG | Biotechnological production of alcohols and derivatives thereof |
| EP2631298A1 (en) | 2012-02-22 | 2013-08-28 | Evonik Industries AG | Biotechnological method for producing butanol and butyric acid |
| EP2639308A1 (de) | 2012-03-12 | 2013-09-18 | Evonik Industries AG | Enzymatische omega-Oxidation und -Aminierung von Fettsäuren |
| EP2647696A1 (de) | 2012-04-02 | 2013-10-09 | Evonik Degussa GmbH | Verfahren zur aeroben Herstellung von Alanin oder einer unter Verbrauch von Alanin entstehenden Verbindung |
| DE102012207921A1 (de) | 2012-05-11 | 2013-11-14 | Evonik Industries Ag | Mehrstufiges Syntheseverfahren mit Synthesegas |
| EP2700448A1 (de) | 2012-08-21 | 2014-02-26 | Evonik Industries AG | Verzweigte Fettsäuren als flüssige Kationenaustauscher |
| ES2531144T3 (es) | 2012-09-07 | 2015-03-11 | Evonik Industries Ag | Composiciones curables a base de resinas epoxídicas sin alcohol bencílico |
| EP2730655A1 (de) | 2012-11-12 | 2014-05-14 | Evonik Industries AG | Verfahren zur Umsetzung eines Carbonsäureesters unter Verwendung BioH-defizienter Zellen |
| EP2746400A1 (de) | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Aminen und Diaminen aus einer Carbonsäure oder Dicarbonsäure oder eines Monoesters davon |
| EP2746397A1 (de) | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Omega-Aminofettsäuren |
| EP2759598A1 (de) | 2013-01-24 | 2014-07-30 | Evonik Industries AG | Verfahren zur Herstellung von alpha, omega-Alkandiol |
| EP2944697A1 (en) | 2014-05-13 | 2015-11-18 | Evonik Degussa GmbH | Method of producing nylon |
| US11174496B2 (en) | 2015-12-17 | 2021-11-16 | Evonik Operations Gmbh | Genetically modified acetogenic cell |
| EP3336180A1 (en) | 2016-07-04 | 2018-06-20 | Evonik Degussa GmbH | Mutant alkb gene |
| EP3490969B1 (en) | 2016-07-27 | 2020-07-22 | Evonik Operations GmbH | N-acetyl homoserine |
| KR20220039767A (ko) * | 2019-07-29 | 2022-03-29 | 에보니크 오퍼레이션즈 게엠베하 | 수성 배지로부터 탄산, 지방족 산, 에스테르 및 알코올을 추출하는 방법 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6245214B1 (en) | 1998-09-18 | 2001-06-12 | Alliedsignal Inc. | Electro-catalytic oxidation (ECO) device to remove CO from reformate for fuel cell application |
| DE10054347A1 (de) | 2000-11-02 | 2002-05-08 | Degussa | Verfahren zur katalytischen Hydrierung organischer Verbindungen und Trägerkatalysatoren hierfür |
| DE10142621A1 (de) | 2001-08-31 | 2003-03-20 | Degussa | Aufarbeitung der Ammoximationsprodukte von Ketonen durch Flüssig-Flüssig-Extraktion in einem ternären Lösemittelsystem |
| DE10142620A1 (de) | 2001-08-31 | 2003-03-20 | Degussa | Ammoximation von Ketonen und Aufarbeitung durch Pervaporation/Dampfpermeation |
| DE50213288D1 (de) | 2002-05-31 | 2009-04-02 | Evonik Degussa Gmbh | Geträgerter Rutheniumkatalysator und Verfahren zur Hydrierung eines aromatischen Amins in Gegenwart dieses Katalysators |
| DE10231119A1 (de) | 2002-07-10 | 2004-02-05 | Degussa Ag | Verfahren zur Selektivitätserhöhung der Hydrierung von 4,4'-Diaminodiphenylmethan zu 4,4'-Diaminodicyclohexylmethan in Gegenwart eines N-Alkyl-4,4'-Diaminodiphenylmethans |
| DE10247495A1 (de) | 2002-10-11 | 2004-04-22 | Degussa Ag | Verfahren zur Epoxidierung cyclischer Alkene |
| EP1424332A1 (en) | 2002-11-26 | 2004-06-02 | Degussa AG | Process for the purification of crude propene oxide |
| US6878836B2 (en) | 2003-06-18 | 2005-04-12 | Degussa Ag | Process for the epoxidation of propene |
| DE102006017760A1 (de) | 2006-03-24 | 2007-09-27 | Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh | Verfahren zur enzymatischen Herstellung von 2-Hydroxy-2-methylcarbonsäuren |
| WO2007131720A1 (en) | 2006-05-11 | 2007-11-22 | Cosmoferm B.V. | Improved production of sphingoid bases using genetically engineered microbial strains |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| DE102007021199B4 (de) | 2006-07-17 | 2016-02-11 | Evonik Degussa Gmbh | Zusammensetzungen aus organischem Polymer als Matrix und anorganischen Partikeln als Füllstoff, Verfahren zu deren Herstellung sowie deren Verwendung und damit hergestellte Formkörper |
| DE102007027006A1 (de) | 2007-06-08 | 2008-12-11 | Evonik Degussa Gmbh | Mikrobiologische Herstellung von Aldehyden, insbesondere von 3-Hydroxypropionaldehyd |
| DE102007052463A1 (de) | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Fermentative Gewinnung von Aceton aus erneuerbaren Rohstoffen mittels neuen Stoffwechselweges |
| DE102007060705A1 (de) | 2007-12-17 | 2009-06-18 | Evonik Degussa Gmbh | ω-Aminocarbonsäuren oder ihre Lactame, herstellende, rekombinante Zellen |
| JP5398004B2 (ja) * | 2007-12-28 | 2014-01-29 | 池田食研株式会社 | 改変型グルコース脱水素酵素遺伝子 |
| DE102008002090A1 (de) | 2008-05-30 | 2009-12-03 | Evonik Degussa Gmbh | Ungesättigte Dicarbonsäuren aus ungesättigten cyclischen Kohlenwasserstoffen und Acrylsäure mittels Metathese, deren Verwendung als Monomere für Polyamide, Polyester, Polyurethane sowie weitere Umsetzung zu DIolen und Diaminen |
| DE102008002715A1 (de) | 2008-06-27 | 2009-12-31 | Evonik Röhm Gmbh | 2-Hydroxyisobuttersäure produzierende rekombinante Zelle |
| DE102008040193A1 (de) | 2008-07-04 | 2010-01-07 | Evonik Röhm Gmbh | Verfahren zur Herstellung freier Carbonsäuren |
| DE102008040415A1 (de) | 2008-07-15 | 2010-01-21 | Evonik Röhm Gmbh | Thermisches Salzspalten von Ammoniumcarboxylaten |
| WO2010022090A1 (en) * | 2008-08-18 | 2010-02-25 | Ls9, Inc. | Systems and methods for the production of mixed fatty esters |
| DE102009000592A1 (de) | 2009-02-04 | 2010-08-05 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Aminogruppen tragenden, multizyklischen Ringsystemen |
| DE102009000661A1 (de) | 2009-02-06 | 2010-08-12 | Evonik Degussa Gmbh | Verfahren zur Herstellung von 2,6-Dioxabicyclo-(3.3.0)-octan-4,8-dion[1S,5S] |
| DE102009000662A1 (de) | 2009-02-06 | 2010-08-12 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Aldehyden und Ketonen aus primären und sekundären Alkoholen |
| DE102009009580A1 (de) | 2009-02-19 | 2010-08-26 | Evonik Degussa Gmbh | Verfahren zur Herstellung freier Säuren aus ihren Salzen |
| DE102009002371A1 (de) | 2009-04-15 | 2010-10-21 | Evonik Goldschmidt Gmbh | Verfahren zur Herstellung von geruchlosen Polyetheralkoholen mittels DMC-Katalysatoren und deren Verwendung in kosmetischen und/oder dermatologischen Zubereitungen |
| EP2425007A4 (en) * | 2009-04-27 | 2013-01-02 | Ls9 Inc | PREPARATION OF FATTY ACID ESTERS |
| DE102009002811A1 (de) | 2009-05-05 | 2010-11-11 | Evonik Degussa Gmbh | Enzymatisches Verfahren zur Herstellung von Aldehyden |
| DE102009046626A1 (de) | 2009-11-11 | 2011-05-12 | Evonik Degussa Gmbh | Candida tropicalis Zellen und deren Verwendung |
| DE102009046910A1 (de) | 2009-11-20 | 2011-05-26 | Evonik Degussa Gmbh | Verfahren zur Aufarbeitung eines Laurinlactam enthaltenen Stoffstroms für die Rückgewinnung aller enthaltene Wertstoffkomponenten durch Kombination von Kristallisation mit nachgeschalteter Destillation |
| US20120315366A1 (en) | 2009-12-23 | 2012-12-13 | Evonik Degussa Gmbh | Sweetener and method of production thereof |
| DE102010015807A1 (de) | 2010-04-20 | 2011-10-20 | Evonik Degussa Gmbh | Biokatalytisches Oxidationsverfahren mit alkL-Genprodukt |
| DE102010023749A1 (de) | 2010-06-14 | 2011-12-15 | Evonik Degussa Gmbh | Zelle und Verfahren zur Herstellung von Resveratrol |
| WO2011157573A2 (de) | 2010-06-14 | 2011-12-22 | Evonik Röhm Gmbh | Ein enzym zur herstellung von methylmalonatsemialdehyd |
| DE102010026196A1 (de) | 2010-06-25 | 2011-12-29 | Evonik Degussa Gmbh | Synthese von omega-Aminocarbonsäuren und deren Estern aus ungesättigten Fettsäurederivaten |
| UA112980C2 (uk) | 2011-02-16 | 2016-11-25 | Евонік Дегусса Гмбх | Рідкі катіоніти |
| DE102011015150A1 (de) | 2011-03-25 | 2012-09-27 | Evonik Degussa Gmbh | Syntese von alpha, omega-Dicarbonsäuren und deren Estern aus ungesättigten Fettsäurederivaten |
| ES2537208T3 (es) | 2011-04-12 | 2015-06-03 | Evonik Degussa Gmbh | Procedimiento realizable continuamente para la preparación de unos compuestos carbonílicos mediante un catalizador que contiene el radical nitroxilo |
| EP2557176A1 (en) | 2011-06-15 | 2013-02-13 | Evonik Degussa GmbH | Enzymatic amination |
| JP6057994B2 (ja) | 2011-07-20 | 2017-01-11 | エボニック デグサ ゲーエムベーハーＥｖｏｎｉｋ Ｄｅｇｕｓｓａ ＧｍｂＨ | 第一級アルコールの酸化及びアミノ化 |
| RU2014108194A (ru) | 2011-08-05 | 2015-09-10 | Эвоник Дегусса Гмбх | Окисление и аминирование вторичных спиртов |
| DE102011110946A1 (de) | 2011-08-15 | 2016-01-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen |
| DE102011110945A1 (de) | 2011-08-15 | 2013-02-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von organischen Verbindungen mit alkIL-Genprodukt |
| EP2730655A1 (de) | 2012-11-12 | 2014-05-14 | Evonik Industries AG | Verfahren zur Umsetzung eines Carbonsäureesters unter Verwendung BioH-defizienter Zellen |
| EP2746397A1 (de) | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Omega-Aminofettsäuren |
| DE102013203470A1 (de) | 2013-03-01 | 2014-09-04 | Evonik Industries Ag | Verfahren zur Herstellung von Ketonen aus Epoxiden |
-
2011
- 2011-12-22 EP EP11195221.4A patent/EP2607490A1/de not_active Withdrawn
-
2012
- 2012-12-18 WO PCT/EP2012/075889 patent/WO2013092547A1/de active Application Filing
- 2012-12-18 EP EP12806038.1A patent/EP2794898B1/de active Active
- 2012-12-18 KR KR1020147016716A patent/KR102000317B1/ko active IP Right Grant
- 2012-12-18 BR BR112014015202-0A patent/BR112014015202B1/pt active IP Right Grant
- 2012-12-18 SG SG11201403495QA patent/SG11201403495QA/en unknown
- 2012-12-18 EP EP12197644.3A patent/EP2607491A1/de not_active Withdrawn
- 2012-12-18 MX MX2012015064A patent/MX339910B/es active IP Right Grant
- 2012-12-18 ES ES12806038.1T patent/ES2688295T3/es active Active
- 2012-12-20 US US13/721,481 patent/US9249435B2/en active Active
- 2012-12-20 CA CA2799883A patent/CA2799883C/en active Active
- 2012-12-21 CN CN201810198137.0A patent/CN108358800B/zh active Active
- 2012-12-21 CN CN2012105994118A patent/CN103254089A/zh active Pending
- 2012-12-25 JP JP2012281367A patent/JP6312117B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20130164797A1 (en) | 2013-06-27 |
| CN108358800B (zh) | 2023-02-17 |
| ES2688295T3 (es) | 2018-10-31 |
| EP2794898A1 (de) | 2014-10-29 |
| EP2794898B1 (de) | 2018-08-01 |
| JP2013132295A (ja) | 2013-07-08 |
| JP6312117B2 (ja) | 2018-04-18 |
| EP2607491A1 (de) | 2013-06-26 |
| EP2607490A1 (de) | 2013-06-26 |
| KR20140111653A (ko) | 2014-09-19 |
| CA2799883A1 (en) | 2013-06-22 |
| BR112014015202A8 (pt) | 2017-06-13 |
| CA2799883C (en) | 2020-09-22 |
| MX2012015064A (es) | 2013-10-16 |
| CN103254089A (zh) | 2013-08-21 |
| WO2013092547A1 (de) | 2013-06-27 |
| BR112014015202A2 (pt) | 2017-06-13 |
| BR112014015202B1 (pt) | 2021-11-03 |
| CN108358800A (zh) | 2018-08-03 |
| SG11201403495QA (en) | 2014-09-26 |
| KR102000317B1 (ko) | 2019-07-15 |
| US9249435B2 (en) | 2016-02-02 |
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