MX338631B - 5-(fenil/piridinil-etinil)-2-piridina/ 2-pirimidina-carboxamidas como moduladores del receptor de glutamato metabotropico del subtipo 5 (mglur5). - Google Patents

5-(fenil/piridinil-etinil)-2-piridina/ 2-pirimidina-carboxamidas como moduladores del receptor de glutamato metabotropico del subtipo 5 (mglur5).

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Publication number
MX338631B
MX338631B MX2013012125A MX2013012125A MX338631B MX 338631 B MX338631 B MX 338631B MX 2013012125 A MX2013012125 A MX 2013012125A MX 2013012125 A MX2013012125 A MX 2013012125A MX 338631 B MX338631 B MX 338631B
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Mexico
Prior art keywords
halogen
lower alkyl
ring
hydrogen
pyridinyl
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MX2013012125A
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English (en)
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MX2013012125A (es
Inventor
Antonio Ricci
Georg Jaeschke
Synese Jolidon
Lothar Lindemann
Heinz Stadler
Eric Vieira
Daniel Rueher
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Hoffmann La Roche
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Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013012125A publication Critical patent/MX2013012125A/es
Publication of MX338631B publication Critical patent/MX338631B/es

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Abstract

La presente invención se refiere a derivados de etinilo de la fórmula I (Ver Formula) en la que: Y es N o y R3 es hidrógeno, metilo, halógeno o nitrilo; R1 es fenilo o piridinilo, que están opcionalmente sustituidos por halógeno, alquilo inferior o alcoxi inferior; con independencia entre sí son hidrógeno, alquilo inferior o alquilo inferior sustituido por halógeno, o R2 y R2' junto con el átomo de N al que están unidos pueden formar un anillo morfolina, un anillo piperidina o un anillo azetidina, que están sin sustituir o sustituidos por uno o más sustituyentes elegidos entre alcoxi inferior, halógeno, hidroxi y metilo; R4/R4' con independencia entre sí son hidrógeno o alquilo inferior, o R4 y R4' juntos forman un anillo cicloalquilo C3-5, tetrahidrofurano u oxetano; o a una sal de adición de ácido farmacéuticamente aceptable, a una mezcla racémica, o a los correspondientes enantiómeros y/o isómeros ópticos y/o estereoisómeros de los mismos. Ahora se ha encontrado de modo sorprendente que los compuestos de la fórmula general I son moduladores alostéricos positivos (PAM) del receptor de glutamato metabotrópico del subtipo 5 (mGluR5).
MX2013012125A 2011-04-19 2012-04-17 5-(fenil/piridinil-etinil)-2-piridina/ 2-pirimidina-carboxamidas como moduladores del receptor de glutamato metabotropico del subtipo 5 (mglur5). MX338631B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11162945 2011-04-19
EP11185137 2011-10-14
PCT/EP2012/056966 WO2012143340A1 (en) 2011-04-19 2012-04-17 5-(phenyl/pyridinyl-ethinyl)-2-pyridine/ 2-pyrimidine-carborxamides as mglur5 modulators

Publications (2)

Publication Number Publication Date
MX2013012125A MX2013012125A (es) 2013-10-30
MX338631B true MX338631B (es) 2016-04-26

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Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
PE20150733A1 (es) * 2012-10-18 2015-05-17 Hoffmann La Roche Derivados de etinilo como moduladores de la actividad del receptor mglur5
CA2882484A1 (en) * 2012-10-18 2014-04-24 F. Hoffmann-La Roche Ag Ethynyl derivatives as modulators of mglur5 receptor activity
JP6458270B2 (ja) * 2013-08-16 2019-01-30 デューク ユニバーシティ 置換されたヒドロキサム酸化合物
KR102035048B1 (ko) 2015-06-03 2019-10-22 에프. 호프만-라 로슈 아게 에틴일 유도체
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