MX337823B - Trombospondina 1 (tsp-1), trombospondina 2 (tsp-2), receptor de interleucina 17b (il-17br) y factor de crecimiento tipo factor de crecimiento epidermico de union a heparina (hb-egf) asociados con actividades de celulas madre y aplicaciones de los mismos. - Google Patents

Trombospondina 1 (tsp-1), trombospondina 2 (tsp-2), receptor de interleucina 17b (il-17br) y factor de crecimiento tipo factor de crecimiento epidermico de union a heparina (hb-egf) asociados con actividades de celulas madre y aplicaciones de los mismos.

Info

Publication number
MX337823B
MX337823B MX2011011961A MX2011011961A MX337823B MX 337823 B MX337823 B MX 337823B MX 2011011961 A MX2011011961 A MX 2011011961A MX 2011011961 A MX2011011961 A MX 2011011961A MX 337823 B MX337823 B MX 337823B
Authority
MX
Mexico
Prior art keywords
tsp
applications
stem cell
cell activities
egf associated
Prior art date
Application number
MX2011011961A
Other languages
English (en)
Other versions
MX2011011961A (es
Inventor
Yoon-Sun Yang
Won Il Oh
Hong Bae Jeon
Mee Hyun Jung
Sang Young Jeong
Original Assignee
Medipost Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medipost Co Ltd filed Critical Medipost Co Ltd
Publication of MX2011011961A publication Critical patent/MX2011011961A/es
Publication of MX337823B publication Critical patent/MX337823B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a una modalidad de ejemplo de la presente invención proporciona TSP-1, TSP-2, IL-17BR y HB-EGF asociados con actividades de células madre y aplicaciones de los mismos.
MX2011011961A 2009-05-13 2010-05-13 Trombospondina 1 (tsp-1), trombospondina 2 (tsp-2), receptor de interleucina 17b (il-17br) y factor de crecimiento tipo factor de crecimiento epidermico de union a heparina (hb-egf) asociados con actividades de celulas madre y aplicaciones de los mismos. MX337823B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20090041753 2009-05-13
US18248409P 2009-05-29 2009-05-29
PCT/KR2010/003040 WO2010131917A2 (ko) 2009-05-13 2010-05-13 줄기세포의 세포 활성과 연관된 ｔｓｐ-1, ｔｓｐ-2, ｉｌ-17ｂｒ 및 ｈｂ-ｅｇｆ 및 이들의 용도

Publications (2)

Publication Number Publication Date
MX2011011961A MX2011011961A (es) 2011-12-06
MX337823B true MX337823B (es) 2016-03-22

Family

ID=43085467

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014009492A MX357440B (es) 2009-05-13 2010-05-13 Trombospondina 1 (tsp-1), trombospondina 2 (tsp-2), receptor de interleucina 17b (il-17br) y factor de crecimiento tipo factor de crecimiento epidermico de union a heparina (hb-egf) asociados con actividades de celulas madre y aplicaciones de los mismos.
MX2011011961A MX337823B (es) 2009-05-13 2010-05-13 Trombospondina 1 (tsp-1), trombospondina 2 (tsp-2), receptor de interleucina 17b (il-17br) y factor de crecimiento tipo factor de crecimiento epidermico de union a heparina (hb-egf) asociados con actividades de celulas madre y aplicaciones de los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2014009492A MX357440B (es) 2009-05-13 2010-05-13 Trombospondina 1 (tsp-1), trombospondina 2 (tsp-2), receptor de interleucina 17b (il-17br) y factor de crecimiento tipo factor de crecimiento epidermico de union a heparina (hb-egf) asociados con actividades de celulas madre y aplicaciones de los mismos.

Country Status (10)

Country Link
EP (2) EP2431460B1 (es)
JP (2) JP5972163B2 (es)
KR (2) KR101211930B1 (es)
CN (1) CN102482645B (es)
CA (1) CA2761610C (es)
ES (1) ES2559235T3 (es)
MX (2) MX357440B (es)
MY (1) MY153917A (es)
SG (1) SG176037A1 (es)
WO (1) WO2010131917A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040298B2 (en) 2009-05-29 2015-05-26 Medipost Co., Ltd. Method of selecting stem cells having high chondrogenic differentiation capability
US20140255364A1 (en) * 2011-10-28 2014-09-11 Tufts University 3d culture system for culturing cells in synovial fluid, cells cultured in synovial fluid and their use
KR101667001B1 (ko) * 2013-08-12 2016-10-17 한국생명공학연구원 줄기세포 배양액에서 탐지 가능한 지방유래 줄기세포의 증식 및 치료능력 탐지용 마커 및 이의 용도
JP6478418B2 (ja) * 2014-07-11 2019-03-06 国立研究開発法人産業技術総合研究所 細胞分化ポテンシャル判別法
CN107206028A (zh) * 2014-12-05 2017-09-26 詹森生物科技公司 使用祖细胞治疗眼部病症
US11614441B2 (en) 2017-06-30 2023-03-28 Kolon Life Science, Inc. Method for assessing validity of cell therapy product

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119921A1 (en) * 1999-03-31 2002-08-29 Michael Streit Thrombospondin-2 and uses thereof
US20020022592A1 (en) * 1999-03-31 2002-02-21 Michael Detmar Delivery of thrombospondin from implantable tissue matrices
US7175840B2 (en) * 2001-01-05 2007-02-13 Viromed Co., Ltd. Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
DE60208042T2 (de) * 2001-08-14 2006-08-17 Medipost, Co., Ltd. Zusammensetzung zur behandlung von schäden des gelenkknorpels
CN1281739C (zh) * 2002-02-19 2006-10-25 美迪宝斯特有限公司 从脐带血中分离并扩大培养间充质干细胞/祖细胞及将脐带血来源的间充质干细胞/祖细胞分化成各种间充质组织的方法
ES2600555T3 (es) * 2003-06-27 2017-02-09 DePuy Synthes Products, Inc. Reparación y regeneración de tejido ocular usando células derivadas del post parto
EP1736173B1 (en) * 2004-03-31 2018-02-28 Two Cells Co., Ltd Damaged tissue therapeutic agent and therapeutic method
US20090162436A1 (en) * 2006-06-14 2009-06-25 Carson Daniel D Compositions and methods for repair of tissues
KR100816395B1 (ko) * 2006-09-21 2008-03-27 (주)필미아젠 세포 유래 세포외기질막의 제조방법
JP2008289476A (ja) * 2007-04-27 2008-12-04 Hiroshima Univ 骨分化状態を測定する組成物および骨分化を調節する組成物

Also Published As

Publication number Publication date
KR101596214B1 (ko) 2016-02-22
MX357440B (es) 2018-07-10
MX2011011961A (es) 2011-12-06
MY153917A (en) 2015-04-15
ES2559235T3 (es) 2016-02-11
KR20120002506A (ko) 2012-01-05
EP2752483B1 (en) 2018-01-17
CA2761610A1 (en) 2010-11-18
EP2752483A1 (en) 2014-07-09
CN102482645A (zh) 2012-05-30
JP6271623B2 (ja) 2018-01-31
CN102482645B (zh) 2015-12-09
JP2012526549A (ja) 2012-11-01
JP2016136159A (ja) 2016-07-28
WO2010131917A2 (ko) 2010-11-18
CA2761610C (en) 2020-12-29
WO2010131917A3 (ko) 2011-06-23
JP5972163B2 (ja) 2016-08-17
EP2431460A4 (en) 2013-06-05
SG176037A1 (en) 2011-12-29
KR101211930B1 (ko) 2012-12-13
EP2431460B1 (en) 2015-10-14
EP2431460A2 (en) 2012-03-21
KR20100122876A (ko) 2010-11-23

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