MX336271B - Compuestos de triazolopiridina inhibidores de jak y los metodos. - Google Patents
Compuestos de triazolopiridina inhibidores de jak y los metodos.Info
- Publication number
- MX336271B MX336271B MX2010014002A MX2010014002A MX336271B MX 336271 B MX336271 B MX 336271B MX 2010014002 A MX2010014002 A MX 2010014002A MX 2010014002 A MX2010014002 A MX 2010014002A MX 336271 B MX336271 B MX 336271B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- inhibitor compounds
- jak inhibitor
- compound
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Un compuesto de la Fórmula I, enantiómeros, diastereómeros, tautómeros o las sales farmacéuticamente aceptables de ellos, donde R1, R2, R3, R4 y R5 están definidos aquí, son útiles como inhibidores de JAK quinasa. Se revelan una composición farmacéutica que incluye un compuesto de la Fórmula I y un portador, adyuvante o vehículo farmacéuticamente aceptable, y los métodos de tratamiento o de disminuir la severidad de una enfermedad o condición sensible de la actividad de JAK quinasa en un paciente. (Ver fórmula I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7451008P | 2008-06-20 | 2008-06-20 | |
PCT/US2009/048041 WO2009155565A1 (en) | 2008-06-20 | 2009-06-19 | Triazolopyridine jak inhibitor compounds and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2010014002A MX2010014002A (es) | 2011-02-15 |
MX336271B true MX336271B (es) | 2016-01-13 |
Family
ID=41434472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010014002A MX336271B (es) | 2008-06-20 | 2009-06-19 | Compuestos de triazolopiridina inhibidores de jak y los metodos. |
Country Status (15)
Country | Link |
---|---|
US (4) | US20100035875A1 (es) |
EP (1) | EP2296475A4 (es) |
JP (1) | JP5595389B2 (es) |
KR (1) | KR20110031475A (es) |
CN (1) | CN102131390A (es) |
AU (1) | AU2009259867A1 (es) |
BR (1) | BRPI0909945A2 (es) |
CA (1) | CA2726844C (es) |
CL (1) | CL2010001486A1 (es) |
IL (1) | IL209764A0 (es) |
MX (1) | MX336271B (es) |
PE (1) | PE20110063A1 (es) |
RU (1) | RU2561104C2 (es) |
SG (1) | SG178807A1 (es) |
WO (1) | WO2009155565A1 (es) |
Families Citing this family (48)
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WO2006020049A2 (en) | 2004-07-15 | 2006-02-23 | Amr Technology, Inc. | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
PE20110545A1 (es) | 2008-06-20 | 2011-08-18 | Genentech Inc | Compuestos de triazolopiridina como inhibidores de jak |
CN102131390A (zh) | 2008-06-20 | 2011-07-20 | 健泰科生物技术公司 | ***并吡啶jak抑制剂化合物和方法 |
JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
TWI453207B (zh) * | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基***并吡啶,其組合物及使用其之治療方法 |
AU2011211410B2 (en) * | 2009-02-13 | 2013-01-31 | Fovea Pharmaceuticals Sa | [1,2,4] triazolo [1,5-A] pyridines as kinase inhibitors |
US20120041195A1 (en) * | 2009-02-13 | 2012-02-16 | Fovea Pharmaceuticals | Heterocyclic compounds |
AU2010247735B2 (en) | 2009-05-12 | 2015-07-16 | Albany Molecular Research, Inc. | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof |
MX2011011907A (es) | 2009-05-12 | 2012-01-20 | Albany Molecular Res Inc | 7-([1,2,4,]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2, 3,4-tetrahidroisoquinolina y uso de la misma. |
ES2446971T3 (es) | 2009-05-12 | 2014-03-11 | Albany Molecular Research, Inc. | Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso |
BRPI1009637A2 (pt) | 2009-06-05 | 2019-04-30 | Cephalon, Inc | composto, composição e uso de um composto |
TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
WO2012000970A1 (en) * | 2010-07-01 | 2012-01-05 | Cellzome Limited | Triazolopyridines as tyk2 inhibitors |
ES2614128T3 (es) | 2010-08-27 | 2017-05-29 | Merck Patent Gmbh | Derivados de triazolopirazina |
ES2582465T3 (es) * | 2010-12-06 | 2016-09-13 | Cephalon, Inc. | Inhibidor Quinasa Janus 2 (JAK2) para el tratamiento del lupus |
JP6046633B2 (ja) * | 2010-12-06 | 2016-12-21 | セファロン、インク. | 1,2,4−トリアゾロ[1,5a]ピリジン誘導体を用いた慢性炎症の治療 |
HUE052198T2 (hu) | 2011-07-21 | 2021-04-28 | Sumitomo Dainippon Pharma Oncology Inc | Heterociklusos protein kináz inhibitorok |
WO2013157021A1 (en) | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
CN105745209B (zh) * | 2013-09-05 | 2018-10-23 | 豪夫迈·罗氏有限公司 | ***并吡啶化合物、组合物及其使用方法 |
US20160303116A1 (en) * | 2013-12-11 | 2016-10-20 | Cephalon, Inc. | Treatment of multiple sclerosis with a 1,2,4-triazolo [1,5a] pyridine derivative |
GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
US10815231B2 (en) | 2016-06-29 | 2020-10-27 | West China Hospital, Sichuan University | [1,2,4] triazolo [1,5-a] pyridine derivative and crystalline form thereof |
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2009
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- 2009-06-19 US US12/488,406 patent/US20100035875A1/en not_active Abandoned
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- 2009-06-19 WO PCT/US2009/048041 patent/WO2009155565A1/en active Application Filing
- 2009-06-19 CA CA2726844A patent/CA2726844C/en not_active Expired - Fee Related
- 2009-06-19 BR BRPI0909945-0A patent/BRPI0909945A2/pt not_active IP Right Cessation
- 2009-06-19 RU RU2011101901/04A patent/RU2561104C2/ru not_active IP Right Cessation
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RU2561104C2 (ru) | 2015-08-20 |
PE20110063A1 (es) | 2011-02-16 |
EP2296475A4 (en) | 2014-03-05 |
WO2009155565A1 (en) | 2009-12-23 |
US20120264747A1 (en) | 2012-10-18 |
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SG178807A1 (en) | 2012-03-29 |
MX2010014002A (es) | 2011-02-15 |
US8889673B2 (en) | 2014-11-18 |
EP2296475A1 (en) | 2011-03-23 |
JP5595389B2 (ja) | 2014-09-24 |
CN102131390A (zh) | 2011-07-20 |
US20160024089A1 (en) | 2016-01-28 |
AU2009259867A1 (en) | 2009-12-23 |
RU2011101901A (ru) | 2012-07-27 |
BRPI0909945A2 (pt) | 2015-07-28 |
JP2011525193A (ja) | 2011-09-15 |
IL209764A0 (en) | 2011-02-28 |
US20100035875A1 (en) | 2010-02-11 |
CA2726844A1 (en) | 2009-12-23 |
CL2010001486A1 (es) | 2011-05-06 |
KR20110031475A (ko) | 2011-03-28 |
US20140378449A1 (en) | 2014-12-25 |
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