MX2023011202A - Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds). - Google Patents

Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds).

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Publication number
MX2023011202A
MX2023011202A MX2023011202A MX2023011202A MX2023011202A MX 2023011202 A MX2023011202 A MX 2023011202A MX 2023011202 A MX2023011202 A MX 2023011202A MX 2023011202 A MX2023011202 A MX 2023011202A MX 2023011202 A MX2023011202 A MX 2023011202A
Authority
MX
Mexico
Prior art keywords
treatment
rara agonists
mds
aml
rara
Prior art date
Application number
MX2023011202A
Other languages
English (en)
Inventor
Matthew Lucas Eaton
Christopher Fiore
Emily Payton Lee
Christian Fritz
Michael Robert Mckeown
Original Assignee
Syros Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syros Pharmaceuticals Inc filed Critical Syros Pharmaceuticals Inc
Publication of MX2023011202A publication Critical patent/MX2023011202A/es

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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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  • Hematology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)

Abstract

Se describen en la presente métodos que definen poblaciones celulares que son sensibles a agonistas RARA y que identifican poblaciones de pacientes que se beneficiarán del tratamiento con agonistas RARA. El método puede comprender administrar agonistas RARA a poblaciones de pacientes.
MX2023011202A 2016-04-08 2018-10-05 Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds). MX2023011202A (es)

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MX2023011202A MX2023011202A (es) 2016-04-08 2018-10-05 Agonistas de receptores alfa de ácido retinoico (rara) para el tratamiento de leucemia mieloide aguda (aml) y síndrome mielodisplásico (mds).

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EP3967305A1 (en) 2015-03-31 2022-03-16 Syros Pharmaceuticals, Inc. Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists
US9868994B2 (en) 2016-04-08 2018-01-16 Syros Pharmaceuticals, Inc. Methods of stratifying patients for treatment with retinoic acid receptor-α agonists

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IL262156B1 (en) 2023-11-01
IL262156A (en) 2018-11-29
AU2017248187A1 (en) 2018-11-01
BR112018070547A2 (pt) 2019-02-12
AU2017248187B2 (en) 2023-03-16
JP7284224B2 (ja) 2023-05-30
CN109310657A (zh) 2019-02-05
KR20180132841A (ko) 2018-12-12
RU2018135302A3 (es) 2020-11-06
AU2023203040A1 (en) 2023-06-08
JP7034085B2 (ja) 2022-03-11
JP2023057151A (ja) 2023-04-20
IL307615A (en) 2023-12-01
WO2017177167A4 (en) 2017-12-21
CN109310657B (zh) 2022-12-13
RU2018135302A (ru) 2020-05-12
MX2018012250A (es) 2019-06-24
IL262156B2 (en) 2024-03-01
CN115737821B (zh) 2024-04-12
CA3020173A1 (en) 2017-10-12
JP2021185171A (ja) 2021-12-09
US20240102106A1 (en) 2024-03-28
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