MX2023008809A - ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS. - Google Patents

ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS.

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Publication number
MX2023008809A
MX2023008809A MX2023008809A MX2023008809A MX2023008809A MX 2023008809 A MX2023008809 A MX 2023008809A MX 2023008809 A MX2023008809 A MX 2023008809A MX 2023008809 A MX2023008809 A MX 2023008809A MX 2023008809 A MX2023008809 A MX 2023008809A
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Mexico
Prior art keywords
cells
nlrc5
rfxank
rfxap
rfx5
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MX2023008809A
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English (en)
Inventor
Blarcom Thomas John Van
Cesar Adolfo Sommer
Michael Thomas Bethune
Eric Hans Gschweng
YI Michael C
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Allogene Therapeutics Inc
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Publication of MX2023008809A publication Critical patent/MX2023008809A/es

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Abstract

En la presente descripción se proporcionan células inmunitarias genomanipuladas y poblaciones de estas para su administración a pacientes para tratar el cáncer (p. ej., tumores sólidos o tumores líquidos) y otras afecciones. Las células se genomanipulan para expresar funcionalmente un nivel reducido de uno o más de RFX5, NLRC5, TAP2, ß2m, TRAC, RFXAP, CIITA y RFXANK. Las células opcionalmente se genomanipulan de manera adicional para expresar una o más de una proteína adicional tal como una proteína de unión a antígenos (p. ej., un receptor quimérico para el antígeno (CAR) o receptor de células T) para dirigirse a células tumorales u otras células dañadas en el paciente y/o para expresar otros genes a un nivel reducido. También se proporcionan métodos para fabricar y usar las células genomanipuladas, composiciones y kits que las comprenden, y métodos para tratar mediante la administración de las células y las composiciones.
MX2023008809A 2021-01-29 2022-01-28 ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS. MX2023008809A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202163143748P 2021-01-29 2021-01-29
US202163176818P 2021-04-19 2021-04-19
US202263267041P 2022-01-21 2022-01-21
PCT/US2022/014393 WO2022165233A1 (en) 2021-01-29 2022-01-28 KNOCKDOWN OR KNOCKOUT OF ONE OR MORE OF TAP2, NLRC5, β2m, TRAC, RFX5, RFXAP AND RFXANK TO MITIGATE T CELL RECOGNITION OF ALLOGENEIC CELL PRODUCTS

Publications (1)

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MX2023008809A true MX2023008809A (es) 2023-08-04

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MX2023008809A MX2023008809A (es) 2021-01-29 2022-01-28 ATENUACIÓN O INACTIVACIÓN DE UNO O MÁS DE TAP2, NLRC5, ß2M, TRAC, RFX5, RFXAP Y RFXANK PARA MITIGAR EL RECONOCIMIENTO DE CÉLULAS T DE PRODUCTOS CELULARES ALOGÉNICOS.

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US (1) US20220251505A1 (es)
EP (1) EP4284918A1 (es)
JP (1) JP2024505075A (es)
KR (1) KR20230142470A (es)
AU (1) AU2022212130A1 (es)
CA (1) CA3204417A1 (es)
IL (1) IL303853A (es)
MX (1) MX2023008809A (es)
WO (1) WO2022165233A1 (es)

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WO2024023802A2 (en) * 2022-07-29 2024-02-01 Crispr Therapeutics Ag Genetically engineered immune cells having disrupted transporter associated with antigen processing-2 (tap-2) gene
US20240042030A1 (en) * 2022-07-29 2024-02-08 Allogene Therapeutics, Inc. Engineered cells with reduced gene expression to mitigate immune cell recognition

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