MX2023003792A - Uso de compuestos de cloroquina y clemizol para el tratamiento de afecciones inflamatorias y cancerosas. - Google Patents
Uso de compuestos de cloroquina y clemizol para el tratamiento de afecciones inflamatorias y cancerosas.Info
- Publication number
- MX2023003792A MX2023003792A MX2023003792A MX2023003792A MX2023003792A MX 2023003792 A MX2023003792 A MX 2023003792A MX 2023003792 A MX2023003792 A MX 2023003792A MX 2023003792 A MX2023003792 A MX 2023003792A MX 2023003792 A MX2023003792 A MX 2023003792A
- Authority
- MX
- Mexico
- Prior art keywords
- chloroquine
- treatment
- inflammatory
- clemizole
- cancerous conditions
- Prior art date
Links
- 229960003677 chloroquine Drugs 0.000 title abstract 3
- CJXAEXPPLWQRFR-UHFFFAOYSA-N clemizole Chemical class C1=CC(Cl)=CC=C1CN1C2=CC=CC=C2N=C1CN1CCCC1 CJXAEXPPLWQRFR-UHFFFAOYSA-N 0.000 title abstract 3
- WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 title 1
- 229950002020 clemizole Drugs 0.000 abstract 2
- 201000007270 liver cancer Diseases 0.000 abstract 2
- 208000014018 liver neoplasm Diseases 0.000 abstract 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen en la presente métodos para uso de R-cloroquina o clemizol o combinaciones de R-cloroquina y clemizol para el tratamiento de un sujeto que necesita del mismo. Los métodos incluyen métodos de tratamiento de afecciones inflamatorias, tratamiento de cáncer hepático o reducción del riesgo de desarrollar cáncer hepático en un sujeto. Los usos también incluyen métodos de tratamiento de esteatohepatitis no alcohólica en un sujeto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562187061P | 2015-06-30 | 2015-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023003792A true MX2023003792A (es) | 2023-04-26 |
Family
ID=57609247
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017016681A MX2017016681A (es) | 2015-06-30 | 2016-06-30 | Uso de compuestos de cloroquina y clemizol para el tratamiento de afecciones inflamatorias y cancerosas. |
MX2022008100A MX2022008100A (es) | 2015-06-30 | 2017-12-18 | Uso de compuestos de cloroquina y clemizol para el tratamiento de afecciones inflamatorias y cancerosas. |
MX2023003792A MX2023003792A (es) | 2015-06-30 | 2017-12-18 | Uso de compuestos de cloroquina y clemizol para el tratamiento de afecciones inflamatorias y cancerosas. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017016681A MX2017016681A (es) | 2015-06-30 | 2016-06-30 | Uso de compuestos de cloroquina y clemizol para el tratamiento de afecciones inflamatorias y cancerosas. |
MX2022008100A MX2022008100A (es) | 2015-06-30 | 2017-12-18 | Uso de compuestos de cloroquina y clemizol para el tratamiento de afecciones inflamatorias y cancerosas. |
Country Status (13)
Country | Link |
---|---|
US (2) | US10688083B2 (es) |
EP (1) | EP3317274A4 (es) |
JP (2) | JP7068827B2 (es) |
KR (2) | KR20180032578A (es) |
CN (2) | CN107922404B (es) |
AU (3) | AU2016288699B2 (es) |
CA (2) | CA2989634C (es) |
HK (1) | HK1249508A1 (es) |
IL (4) | IL300476B1 (es) |
MX (3) | MX2017016681A (es) |
TW (3) | TWI830262B (es) |
WO (1) | WO2017004454A1 (es) |
ZA (1) | ZA201708471B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI830262B (zh) * | 2015-06-30 | 2024-01-21 | 美商伊格集團國際股份有限公司 | 克立咪唑(clemizole)化合物於預防及治療肝癌之用途 |
CN106831571A (zh) * | 2017-02-13 | 2017-06-13 | 中卫市创科知识产权投资有限公司 | 一种硫酸氯喹生产工艺 |
CA3082591A1 (en) * | 2017-11-15 | 2019-05-23 | Beth Israel Deaconess Medical Center, Inc. | Markers for the diagnosis and treatment of non-alcoholic steatohepatitis (nash) and advanced liver fibrosis |
CN113354581B (zh) * | 2020-03-06 | 2023-06-20 | 华南理工大学 | 手性氯喹及其磷酸盐的制备方法及其应用 |
CN111551645B (zh) * | 2020-04-30 | 2022-11-08 | 上海中西三维药业有限公司 | 一种硫酸羟氯喹有关物质的检测方法及其应用 |
CN115515935A (zh) * | 2020-04-30 | 2022-12-23 | 中美华世通生物医药科技(武汉)股份有限公司 | 冠状病毒感染的治疗或预防 |
CN111909087A (zh) * | 2020-06-15 | 2020-11-10 | 珠海润都制药股份有限公司 | 一种手性氨基氯喹啉的制备方法 |
CN111662229B (zh) * | 2020-07-08 | 2023-03-24 | 精华制药集团南通有限公司 | 一种磷酸氯喹的制备工艺 |
CN111793026A (zh) * | 2020-07-23 | 2020-10-20 | 珠海润都制药股份有限公司 | 一种硫酸羟氯喹及其对映体的晶型和制备方法 |
CN114057640A (zh) * | 2020-08-05 | 2022-02-18 | 凯特立斯(深圳)科技有限公司 | 一种光学纯(r)/(s)-羟氯喹侧链的不对称合成方法 |
CN112225697B (zh) * | 2020-10-16 | 2023-01-03 | 宁波大学 | 一种对映体纯氯喹及磷酸氯喹的制备方法 |
CN114573464A (zh) * | 2022-03-02 | 2022-06-03 | 重庆南松凯博生物制药有限公司 | 一种羟氯喹侧链精制方法 |
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AU2003219160A1 (en) * | 2003-03-12 | 2004-09-30 | Molecular Engines Laboratories Sa | Methods and compositions for the treatment of cancer |
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TWI830262B (zh) * | 2015-06-30 | 2024-01-21 | 美商伊格集團國際股份有限公司 | 克立咪唑(clemizole)化合物於預防及治療肝癌之用途 |
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2016
- 2016-06-30 TW TW111123545A patent/TWI830262B/zh active
- 2016-06-30 EP EP16818845.6A patent/EP3317274A4/en active Pending
- 2016-06-30 WO PCT/US2016/040566 patent/WO2017004454A1/en active Application Filing
- 2016-06-30 US US15/738,827 patent/US10688083B2/en active Active
- 2016-06-30 MX MX2017016681A patent/MX2017016681A/es unknown
- 2016-06-30 KR KR1020187002620A patent/KR20180032578A/ko not_active IP Right Cessation
- 2016-06-30 IL IL300476A patent/IL300476B1/en unknown
- 2016-06-30 AU AU2016288699A patent/AU2016288699B2/en active Active
- 2016-06-30 CN CN201680039155.3A patent/CN107922404B/zh active Active
- 2016-06-30 CA CA2989634A patent/CA2989634C/en active Active
- 2016-06-30 CA CA3178499A patent/CA3178499A1/en active Pending
- 2016-06-30 TW TW112136665A patent/TW202402283A/zh unknown
- 2016-06-30 TW TW105120868A patent/TWI771272B/zh active
- 2016-06-30 IL IL310969A patent/IL310969A/en unknown
- 2016-06-30 KR KR1020237028986A patent/KR20230129590A/ko not_active Application Discontinuation
- 2016-06-30 JP JP2017568408A patent/JP7068827B2/ja active Active
- 2016-06-30 CN CN202110651428.2A patent/CN113274386A/zh active Pending
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2017
- 2017-12-10 IL IL256233A patent/IL256233A/en active IP Right Grant
- 2017-12-13 ZA ZA2017/08471A patent/ZA201708471B/en unknown
- 2017-12-18 MX MX2022008100A patent/MX2022008100A/es unknown
- 2017-12-18 MX MX2023003792A patent/MX2023003792A/es unknown
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2018
- 2018-07-11 HK HK18109030.3A patent/HK1249508A1/zh unknown
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2020
- 2020-05-07 US US16/869,312 patent/US20210052553A1/en active Pending
- 2020-11-26 IL IL279020A patent/IL279020B2/en unknown
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2021
- 2021-02-25 AU AU2021201234A patent/AU2021201234A1/en not_active Abandoned
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2022
- 2022-05-02 JP JP2022075974A patent/JP7470151B2/ja active Active
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2023
- 2023-03-07 AU AU2023201397A patent/AU2023201397A1/en active Pending
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