MX2023002125A - Proteínas de unión a antígenos con disulfuro no canónico en la región fab. - Google Patents
Proteínas de unión a antígenos con disulfuro no canónico en la región fab.Info
- Publication number
- MX2023002125A MX2023002125A MX2023002125A MX2023002125A MX2023002125A MX 2023002125 A MX2023002125 A MX 2023002125A MX 2023002125 A MX2023002125 A MX 2023002125A MX 2023002125 A MX2023002125 A MX 2023002125A MX 2023002125 A MX2023002125 A MX 2023002125A
- Authority
- MX
- Mexico
- Prior art keywords
- fab region
- antigen binding
- binding proteins
- canonical disulfide
- multispecific
- Prior art date
Links
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 title 1
- 102000025171 antigen binding proteins Human genes 0.000 title 1
- 108091000831 antigen binding proteins Proteins 0.000 title 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
Abstract
La capacidad de generar una única construcción basada en anticuerpos que pueda reconocer múltiples dianas simultáneamente es fundamental para hacer avanzar muchos candidatos terapéuticos a la clínica. A menudo, esto implica un diseño de proteínas extenso con varios grados de éxito. En el caso de los anticuerpos multiespecíficos, la conducción del emparejamiento HC/LC en la región Fab representa uno de los desafíos más difíciles hasta el momento en el campo de la ingeniería multiespecífica. En el presente documento se describe el descubrimiento de una nueva ubicación para un enlace disulfuro no canónico y, como tal, la generación de una interfaz de cisteína asimétrica entre dos Fab presentes en la misma molécula que permitirá además la producción de multiespecíficos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063068306P | 2020-08-20 | 2020-08-20 | |
PCT/US2021/046770 WO2022040466A1 (en) | 2020-08-20 | 2021-08-19 | Antigen binding proteins with non-canonical disulfide in fab region |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023002125A true MX2023002125A (es) | 2023-04-26 |
Family
ID=78032483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023002125A MX2023002125A (es) | 2020-08-20 | 2021-08-19 | Proteínas de unión a antígenos con disulfuro no canónico en la región fab. |
Country Status (7)
Country | Link |
---|---|
US (1) | US20230322955A1 (es) |
EP (1) | EP4200338A1 (es) |
JP (1) | JP2023538897A (es) |
AU (1) | AU2021329374A1 (es) |
CA (1) | CA3191710A1 (es) |
MX (1) | MX2023002125A (es) |
WO (1) | WO2022040466A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4347655A1 (en) | 2021-06-04 | 2024-04-10 | Amgen Inc. | Anti-ccr8 antibodies and uses thereof |
Family Cites Families (54)
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US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
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US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
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DE68925971T2 (de) | 1988-09-23 | 1996-09-05 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US6713610B1 (en) | 1990-01-12 | 2004-03-30 | Raju Kucherlapati | Human antibodies derived from immunized xenomice |
DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
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WO1993001227A1 (en) | 1991-07-08 | 1993-01-21 | University Of Massachusetts At Amherst | Thermotropic liquid crystal segmented block copolymer |
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WO2019178539A1 (en) * | 2018-03-16 | 2019-09-19 | Ngm Biopharmaceuticals, Inc. | Bispecific antibodies |
-
2021
- 2021-08-19 EP EP21783605.5A patent/EP4200338A1/en active Pending
- 2021-08-19 JP JP2023511804A patent/JP2023538897A/ja active Pending
- 2021-08-19 AU AU2021329374A patent/AU2021329374A1/en active Pending
- 2021-08-19 WO PCT/US2021/046770 patent/WO2022040466A1/en unknown
- 2021-08-19 CA CA3191710A patent/CA3191710A1/en active Pending
- 2021-08-19 MX MX2023002125A patent/MX2023002125A/es unknown
- 2021-08-19 US US18/042,267 patent/US20230322955A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2023538897A (ja) | 2023-09-12 |
CA3191710A1 (en) | 2022-02-24 |
US20230322955A1 (en) | 2023-10-12 |
EP4200338A1 (en) | 2023-06-28 |
WO2022040466A1 (en) | 2022-02-24 |
AU2021329374A1 (en) | 2023-03-09 |
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