MX2023002037A - Proceso e intermediarios para preparar un inhibidor de las cinasas de janus (jak). - Google Patents

Proceso e intermediarios para preparar un inhibidor de las cinasas de janus (jak).

Info

Publication number
MX2023002037A
MX2023002037A MX2023002037A MX2023002037A MX2023002037A MX 2023002037 A MX2023002037 A MX 2023002037A MX 2023002037 A MX2023002037 A MX 2023002037A MX 2023002037 A MX2023002037 A MX 2023002037A MX 2023002037 A MX2023002037 A MX 2023002037A
Authority
MX
Mexico
Prior art keywords
preparing
intermediates
jak inhibitor
jak
inhibitor
Prior art date
Application number
MX2023002037A
Other languages
English (en)
Inventor
Shili Chen
Pingli Liu
Michael Xia
Yongchun Pan
David J Meloni
Weiguo Liu
Jiacheng Zhou
James M Parks
Naijing Su
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2023002037A publication Critical patent/MX2023002037A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se relaciona con procesos para preparar ruxolitinib, o una sal de este, e intermediarios relacionados sintéticos asociados a estos.
MX2023002037A 2020-08-18 2021-08-17 Proceso e intermediarios para preparar un inhibidor de las cinasas de janus (jak). MX2023002037A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063067097P 2020-08-18 2020-08-18
US202163214012P 2021-06-23 2021-06-23
US202163217498P 2021-07-01 2021-07-01
PCT/US2021/046298 WO2022040180A1 (en) 2020-08-18 2021-08-17 Process and intermediates for preparing a jak inhibitor

Publications (1)

Publication Number Publication Date
MX2023002037A true MX2023002037A (es) 2023-06-12

Family

ID=77655708

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023002037A MX2023002037A (es) 2020-08-18 2021-08-17 Proceso e intermediarios para preparar un inhibidor de las cinasas de janus (jak).

Country Status (16)

Country Link
US (2) US11905292B2 (es)
EP (1) EP4200300A1 (es)
JP (1) JP2023539126A (es)
KR (1) KR20230096973A (es)
AU (1) AU2021329303A1 (es)
CA (1) CA3192099A1 (es)
CL (1) CL2023000480A1 (es)
CO (1) CO2023003281A2 (es)
CR (1) CR20230129A (es)
DO (1) DOP2023000035A (es)
EC (1) ECSP23019417A (es)
IL (1) IL300555A (es)
MX (1) MX2023002037A (es)
PE (1) PE20231743A1 (es)
TW (1) TW202227448A (es)
WO (1) WO2022040180A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023002035A (es) 2020-08-18 2023-06-12 Incyte Corp Proceso e intermediarios para preparar un inhibidor de cinasa janus 1 (jak1).
CN115850115B (zh) * 2022-11-25 2023-08-01 上海药坦药物研究开发有限公司 鲁索利替尼中间体及其制备方法

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB812366A (en) 1955-08-18 1959-04-22 Wellcome Found Improvements in and relating to derivatives of pyrimidine and the preparation thereof
US5102904A (en) 1989-12-08 1992-04-07 American Cyanamid Company N-oxygenated arylpyrrole insecticidal, acaricidal and nematicidal agents and use thereas
EP1551410A2 (en) 2002-09-06 2005-07-13 Smithkline Beecham Corporation Novel compounds
CA2566160C (en) 2004-05-27 2011-01-18 Pfizer Products Inc. Pyrrolopyrimidine derivatives useful in cancer treatment
AR054416A1 (es) 2004-12-22 2007-06-27 Incyte Corp Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
KR100987870B1 (ko) 2005-07-29 2010-10-13 화이자 프로덕츠 인코포레이티드 피롤로[2,3-ｄ]피리미딘 유도체, 이들의 중간체 및 합성
HUE030235T2 (en) 2005-12-13 2017-04-28 Incyte Holdings Corp Heteroaryl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors
CN2928286Y (zh) 2006-01-06 2007-08-01 水城钢铁（集团）有限责任公司 预入口导卫装置
EA031335B1 (ru) 2006-02-02 2018-12-28 Миллениум Фармасьютикалз, Инк. Производные пирролопиримидинов
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
EP3070090B1 (en) 2007-06-13 2018-12-12 Incyte Holdings Corporation Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
AU2008281543A1 (en) 2007-08-01 2009-02-05 Pfizer Inc. Pyrazole compounds and their use as Raf inhibitors
NZ585139A (en) 2007-11-16 2012-05-25 Incyte Corp 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as jak inhibitors
ES2602577T3 (es) 2008-03-11 2017-02-21 Incyte Holdings Corporation Derivados de azetidina y ciclobutano como inhibidores de JAK
CL2009001884A1 (es) 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
JOP20190231A1 (ar) 2009-01-15 2017-06-16 Incyte Corp طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
WO2010116282A1 (en) 2009-04-10 2010-10-14 Pfizer Inc. 4, 5-dihydro-lh-pyrazole compounds and their pharmaceutical uses
EA020494B1 (ru) 2009-05-22 2014-11-28 Инсайт Корпорейшн 3-[4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ]ОКТАН- ИЛИ ГЕПТАННИТРИЛ КАК JAK-ИНГИБИТОРЫ
AR076794A1 (es) 2009-05-22 2011-07-06 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
AR078012A1 (es) 2009-09-01 2011-10-05 Incyte Corp Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus
WO2011044481A1 (en) 2009-10-09 2011-04-14 Incyte Corporation Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
CN105906631A (zh) 2009-11-18 2016-08-31 普莱希科公司 用于激酶调节的化合物和方法及其适应症
BR112012020693B1 (pt) 2010-02-18 2020-05-12 Incyte Holdings Corporation Derivados de ciclobutano e metilciclobutano como inibidores de janus quinase e composição que os compreende
MX347851B (es) 2010-03-10 2017-05-16 Incyte Corp Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
TWI619713B (zh) 2010-04-21 2018-04-01 普雷辛肯公司 用於激酶調節的化合物和方法及其適應症
EP3087972A1 (en) 2010-05-21 2016-11-02 Incyte Holdings Corporation Topical formulation for a jak inhibitor
SG190839A1 (en) 2010-11-19 2013-07-31 Incyte Corp Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
EP2640725B1 (en) 2010-11-19 2015-01-07 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
AR086983A1 (es) 2011-06-20 2014-02-05 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
MX365311B (es) 2011-08-12 2019-05-29 Nissan Chemical Ind Ltd Compuestos heterocíclicos tricíclicos inhibidores de jak.
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
AR091079A1 (es) 2012-05-18 2014-12-30 Incyte Corp Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak
KR20220162825A (ko) 2012-11-15 2022-12-08 인사이트 홀딩스 코포레이션 룩솔리티니브의 서방성 제형
AU2014225938B2 (en) 2013-03-06 2018-07-19 Incyte Holdings Corporation Processes and intermediates for making a JAK inhibitor
DK3786162T3 (da) 2013-05-17 2023-10-09 Incyte Holdings Corp Bipyrazolderivater som jak-inhibitorer
KR20160045081A (ko) 2013-08-07 2016-04-26 인사이트 코포레이션 Jak1 억제제용 지속 방출 복용 형태
TW201625643A (zh) 2014-04-30 2016-07-16 英塞特公司 製備ｊａｋ１抑制劑之方法及其新形式
EP3183252B1 (en) 2014-08-21 2021-05-12 ratiopharm GmbH Oxalate salt of ruxolitinib
EP3183253B1 (en) 2014-08-21 2018-06-27 ratiopharm GmbH Salt of (r)-3-(4-(7h-pyrrolo [2,3-d]pyrimidin-4-yl)-lh-pyrazol-l-yl)-3-cyclopentylpropanenitrile with benzenesulfonic acid
WO2016035014A1 (en) 2014-09-01 2016-03-10 Sun Pharmaceutical Industries Limited Processes for the preparation of ruxolitinib phosphate
WO2016063294A2 (en) 2014-10-20 2016-04-28 Msn Laboratories Private Limited Process for the preparation of (r)-3-(4-(7h-pyrrolo[2,3-d], pyrimidin-4-yl)-1 h-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate and its polymorphs thereof
CU20170105A7 (es) 2015-02-24 2017-10-05 Pfizer Derivados de nucleosidos sustituidos útiles como agentes antineoplásicos
CN106397443A (zh) 2015-07-17 2017-02-15 浙江九洲药业股份有限公司 一种吡咯嘧啶类衍生物中间体的制备方法
CZ2015575A3 (cs) 2015-08-26 2017-03-08 Zentiva, K.S. Soli 5-fluoro-3-fenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4-onu a jejich příprava
CA3008909C (en) 2015-12-23 2023-10-03 The University Of British Columbia Lipid-linked prodrugs
CN108699063B (zh) 2015-12-31 2020-06-26 正大天晴药业集团股份有限公司 一种芦可替尼的合成工艺
CZ201629A3 (cs) 2016-01-22 2017-08-02 Zentiva, K.S. Krystalické modifikace solí (3R)-3-cyklopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propannitrilu a způsoby jejich přípravy
CN107513069A (zh) 2016-06-16 2017-12-26 正大天晴药业集团股份有限公司 手性吡咯并嘧啶化合物的制备方法
IN201641026603A (es) 2016-08-04 2018-02-09
CN107722012B (zh) 2016-08-11 2020-05-29 斯福瑞（南通）制药有限公司 制备4-氯-7H-吡咯并[2,3-d]嘧啶的方法
CN107759601B (zh) 2016-08-23 2020-09-11 苏州旺山旺水生物医药有限公司 一种jak抑制剂及其盐的制备方法
CN107759623B (zh) 2016-08-23 2020-08-14 苏州旺山旺水生物医药有限公司 Jak抑制剂的中间体及其制备方法
JP2019532944A (ja) 2016-09-23 2019-11-14 セルイプセ Ｌｉｍｋ介在性疾患における、ｌｉｍキナーゼ阻害剤、医薬組成物および使用方法
CN109651424B (zh) 2017-10-11 2021-01-22 新发药业有限公司 一种7-保护基-4-(1-氢-吡唑-4-基)吡咯[2,3-d]嘧啶的合成方法
US10766900B2 (en) 2017-12-29 2020-09-08 Formosa Laboratories, Inc. Baricitinib intermediate, method for forming Baricitinib intermediate, and method for preparing Baricitinib or pharmaceutically acceptable salt thereof
TWI797242B (zh) 2018-01-30 2023-04-01 美商英塞特公司 製備ｊａｋ抑制劑之方法及中間物
KR20210011922A (ko) 2018-05-21 2021-02-02 피아이 인더스트리스 엘티디. 치환된 헤테로사이클릭 화합물의 제조 방법
JP2022520047A (ja) 2019-02-06 2022-03-28 コンサート ファーマシューティカルズ インコーポレイテッド 鏡像異性的に濃縮されたｊａｋ阻害剤を調製するための方法
CN110724145A (zh) 2019-11-01 2020-01-24 廖文杰 一种医药中间体4-氯吡咯并嘧啶的合成方法
MX2023002035A (es) 2020-08-18 2023-06-12 Incyte Corp Proceso e intermediarios para preparar un inhibidor de cinasa janus 1 (jak1).
WO2023288197A1 (en) 2021-07-12 2023-01-19 Incyte Corporation Process and intermediates for preparing baricitinib
CN113480546A (zh) 2021-07-30 2021-10-08 江苏君若药业有限公司 巴瑞克替尼及其衍生物的制备

Also Published As

Publication number Publication date
KR20230096973A (ko) 2023-06-30
AU2021329303A1 (en) 2023-04-06
CL2023000480A1 (es) 2023-08-04
WO2022040180A1 (en) 2022-02-24
EP4200300A1 (en) 2023-06-28
TW202227448A (zh) 2022-07-16
CR20230129A (es) 2023-07-13
IL300555A (en) 2023-04-01
ECSP23019417A (es) 2023-04-28
CA3192099A1 (en) 2022-02-24
PE20231743A1 (es) 2023-10-31
DOP2023000035A (es) 2023-06-15
JP2023539126A (ja) 2023-09-13
CO2023003281A2 (es) 2023-06-30
US11905292B2 (en) 2024-02-20
US20220056035A1 (en) 2022-02-24
US20240166655A1 (en) 2024-05-23

Similar Documents

Publication Publication Date Title
MX2023002035A (es) Proceso e intermediarios para preparar un inhibidor de cinasa janus 1 (jak1).
PH12019502264A1 (en) Fused imidazo-piperidine jak inhibitors compound
MX2023002037A (es) Proceso e intermediarios para preparar un inhibidor de las cinasas de janus (jak).
PH12019502286A1 (en) Process for preparing an optically active pyrimidinium compounds
PH12021550388A1 (en) Process for preparing jak inhibitors and intermediates thereof
MY186296A (en) Novel promoter and use thereof
MX2021015546A (es) Proceso para preparar 4-amino-piridazinas.
PH12019502386A1 (en) Process for preparing s-containing pyrimidinium compounds
MX2021008965A (es) Proceso para preparar un agonista dual de gip/glp1.
EP4265597A3 (en) Synthesis of omecamtiv mecarbil
ZA202306226B (en) Sulfone derivative production method
EA202090933A1 (ru) Способ получения гербицидных соединений пиридазинона
MX2019001228A (es) Metodo de produccion del compuesto de pirazol-amida.
MX2022002017A (es) Metodo para producir derivado de heterociclideno acetamida.
IL279168B (en) A process for the preparation of eribulin
MX2019009242A (es) Un proceso novedoso para la sintesis de 1-aril-1-trifluoro-metil-c iclopropanos.
MX2021007511A (es) Procedimiento para la preparacion de anilinas sustituidas.
MX2023004950A (es) Proceso para purificacion de pleuromutilinas.
MX2023000970A (es) Metodo de preparacion de aminofuranos.
CL2021000663A1 (es) Proceso para la producción de gas de síntesis.
MX2020010343A (es) Proceso para la purificacion de biocomposiciones complejas.
MX2022006044A (es) Proceso para preparar analogos de araquidonoiletanolamina.
MX2022006856A (es) Proceso e intermediarios para la produccion de formula (i).
AU2019248350A8 (en) Process for making sarecycline hydrochloride
ZA202301455B (en) Process for preparation of mesotrione and its intermediates