MX2023000519A - Derivados de pirido-oxazina-amino como inhibidores de alk5. - Google Patents

Derivados de pirido-oxazina-amino como inhibidores de alk5.

Info

Publication number
MX2023000519A
MX2023000519A MX2023000519A MX2023000519A MX2023000519A MX 2023000519 A MX2023000519 A MX 2023000519A MX 2023000519 A MX2023000519 A MX 2023000519A MX 2023000519 A MX2023000519 A MX 2023000519A MX 2023000519 A MX2023000519 A MX 2023000519A
Authority
MX
Mexico
Prior art keywords
oxazine
pyrido
amino derivatives
alk5 inhibitors
alk5
Prior art date
Application number
MX2023000519A
Other languages
English (en)
Inventor
Matteo Biagetti
Barbara Bertani
Paolo Ronchi
Claudio Fiorelli
Paolo Bruno
Daniela Pizzirani
Daniele Pala
Sara Guariento
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of MX2023000519A publication Critical patent/MX2023000519A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Abstract

La presente invención se refiere a un compuesto de la fórmula general (I) que inhibe el receptor tipo I del factor de crecimiento transformante ß (TGF-ß) (ALK5), métodos para preparar estos compuestos, composiciones farmacéuticas que los contienen y uso terapéutico de los mismos. Los compuestos de la invención pueden ser útiles en el tratamiento de enfermedades o condiciones asociadas con una desregulación de la vía de señalización de ALK5 en un mamífero.
MX2023000519A 2020-07-15 2021-07-14 Derivados de pirido-oxazina-amino como inhibidores de alk5. MX2023000519A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20185900 2020-07-15
PCT/EP2021/069657 WO2022013312A1 (en) 2020-07-15 2021-07-14 Pyrido oxazine amino derivatives as alk5 inhibitors

Publications (1)

Publication Number Publication Date
MX2023000519A true MX2023000519A (es) 2023-02-13

Family

ID=71620265

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023000519A MX2023000519A (es) 2020-07-15 2021-07-14 Derivados de pirido-oxazina-amino como inhibidores de alk5.

Country Status (10)

Country Link
EP (1) EP4182323B1 (es)
JP (1) JP2023533850A (es)
KR (1) KR20230041003A (es)
CN (1) CN116075307A (es)
AR (1) AR122982A1 (es)
AU (1) AU2021307560A1 (es)
BR (1) BR112023000592A2 (es)
CA (1) CA3185108A1 (es)
MX (1) MX2023000519A (es)
WO (1) WO2022013312A1 (es)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2187473T3 (es) 1999-04-09 2003-06-16 Smithkline Beecham Corp Triarylimidazoles.
AR029803A1 (es) 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
GB0007405D0 (en) 2000-03-27 2000-05-17 Smithkline Beecham Corp Compounds
AR039241A1 (es) 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
US20050165011A1 (en) * 2002-05-15 2005-07-28 Gellibert Francoise J. Benzoxazine and benzoxazinone substituted triazoles
PT2044056E (pt) 2006-07-14 2012-12-05 Novartis Ag Derivados de pirimidina como inibidores de alk-5
JP5090528B2 (ja) 2007-07-26 2012-12-05 ノバルティス アーゲー ＡＬＫ４またはＡＬＫ５が介在する疾患を処置するための２、３、７位置換イミダゾ［１，２−ｂ］ピリダジン類
EP2212323B1 (en) 2007-10-17 2012-08-15 Novartis AG Imidazo [1,2-a] pyridine derivatives useful as alk inhibitors
EA201001129A1 (ru) 2008-01-11 2011-02-28 Новартис Аг Пиримидины в качестве ингибиторов киназы
AR070127A1 (es) 2008-01-11 2010-03-17 Novartis Ag Pirrolo - pirimidinas y pirrolo -piridinas
US8343966B2 (en) 2008-01-11 2013-01-01 Novartis Ag Organic compounds
PL2307402T3 (pl) 2008-04-29 2013-05-31 Novartis Ag Pochodne imidazo-pirydyny jako inhibitory kinazy podobnej do receptora aktywiny (ALK4 lub ALK5)
WO2011146287A1 (en) * 2010-05-20 2011-11-24 Takeda Pharmaceutical Company Limited Pyrazolo[4,3-b]pyridine-7-amine inhibitors of alk5
PT2731949T (pt) 2011-07-13 2018-06-15 Tiumbio Co Ltd Imidazóis substituídos com 2-piridilo como inibidores de alk5 e/ou alk4
WO2018215668A1 (en) 2017-05-26 2018-11-29 Glenmark Pharmaceuticals S.A. Novel inhibitors of map4k1
US20200247812A1 (en) * 2018-07-10 2020-08-06 Integral Biosciences Private Limited Heterocyclic compounds and methods of use

Also Published As

Publication number Publication date
EP4182323B1 (en) 2024-04-24
BR112023000592A2 (pt) 2023-01-31
KR20230041003A (ko) 2023-03-23
JP2023533850A (ja) 2023-08-04
WO2022013312A1 (en) 2022-01-20
CA3185108A1 (en) 2022-01-20
AU2021307560A1 (en) 2023-02-23
AR122982A1 (es) 2022-10-19
EP4182323A1 (en) 2023-05-24
CN116075307A (zh) 2023-05-05

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