BR112022014401A2 - Ligante de il-7r-alfa, composto, composição farmacêutica e ácido nucleico - Google Patents

Ligante de il-7r-alfa, composto, composição farmacêutica e ácido nucleico

Info

Publication number
BR112022014401A2
BR112022014401A2 BR112022014401A BR112022014401A BR112022014401A2 BR 112022014401 A2 BR112022014401 A2 BR 112022014401A2 BR 112022014401 A BR112022014401 A BR 112022014401A BR 112022014401 A BR112022014401 A BR 112022014401A BR 112022014401 A2 BR112022014401 A2 BR 112022014401A2
Authority
BR
Brazil
Prior art keywords
compound
nucleic acid
pharmaceutical composition
alpha ligand
ligands
Prior art date
Application number
BR112022014401A
Other languages
English (en)
Inventor
J Dower William
C Needels Michael
W Barrett Ronald
V Bakker Alice
E Cwirla Steven
Original Assignee
Medikine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medikine Inc filed Critical Medikine Inc
Publication of BR112022014401A2 publication Critical patent/BR112022014401A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

LIGANTE DE IL-7R-ALFA, COMPOSTO, COMPOSIÇÃO FARMACÊUTICA E ÁCIDO NUCLEICO. Ligantes de IL-7Ra e compostos compreendendo ligantes de IL-7Ra são divulgados. Os compostos de ligação de IL-7Ra incluem proteínas de fusão compreendendo os ligantes de IL-7Ra e podem atuar como agonistas de IL-7R.
BR112022014401A 2020-02-03 2021-02-03 Ligante de il-7r-alfa, composto, composição farmacêutica e ácido nucleico BR112022014401A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062969432P 2020-02-03 2020-02-03
PCT/US2021/016356 WO2021158619A1 (en) 2020-02-03 2021-02-03 IL-7Rα BINDING COMPOUNDS

Publications (1)

Publication Number Publication Date
BR112022014401A2 true BR112022014401A2 (pt) 2022-11-16

Family

ID=77200522

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022014401A BR112022014401A2 (pt) 2020-02-03 2021-02-03 Ligante de il-7r-alfa, composto, composição farmacêutica e ácido nucleico

Country Status (12)

Country Link
US (2) US11254729B2 (pt)
EP (1) EP4100046A4 (pt)
JP (1) JP2023512687A (pt)
KR (1) KR20220156533A (pt)
CN (1) CN115297886A (pt)
AU (1) AU2021217959A1 (pt)
BR (1) BR112022014401A2 (pt)
CA (1) CA3169452A1 (pt)
IL (1) IL295303A (pt)
MX (1) MX2022009302A (pt)
TW (1) TWI823054B (pt)
WO (1) WO2021158619A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112585160A (zh) 2018-08-06 2021-03-30 麦地金公司 Il-2受体结合化合物
KR20220110209A (ko) 2019-11-05 2022-08-05 메디카인 인코포레이티드 이중 il-2r 및 il-7r 결합 화합물
CN115087664A (zh) 2019-11-05 2022-09-20 麦地金公司 IL-2Rβγc结合化合物
KR20220139918A (ko) 2020-02-03 2022-10-17 메디카인 인코포레이티드 IL-7Rαγc 결합 화합물
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
US11999771B2 (en) * 2022-04-07 2024-06-04 Medikine, Inc. IL-7Rαγc ligand immunoglobulin fusion proteins
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
US20240101959A1 (en) 2022-09-06 2024-03-28 Medikine, Inc. Use of il-2r-beta-gamma agonist peptides in cell manufacturing
US20240100159A1 (en) 2022-09-06 2024-03-28 Medikine, Inc. Use of il-7r-alpha-gamma agonist peptides in cell manufacturing

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635597A (en) 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
US6890734B2 (en) * 2000-11-10 2005-05-10 Schering Corporation Nucleic acids encoding a cytokine receptor complex
AU2002357784B2 (en) 2001-12-04 2008-07-31 Merck Patent Gmbh Immunocytokines with modulated selectivity
US20050054054A1 (en) * 2002-11-12 2005-03-10 Foss Francine M. Interleukin-7 molecules with altered biological properties
AU2004309050B2 (en) 2003-12-30 2010-10-14 Merck Patent Gmbh IL-7 fusion proteins
AU2005313492B2 (en) * 2004-12-09 2011-12-15 Merck Patent Gmbh IL-7 variants with reduced immunogenicity
US20120210458A9 (en) 2009-02-27 2012-08-16 Yongwei Cao Isolated Novel Nucleic Acid and Protein Molecules from Corn and Methods of Using Thereof
RS61854B1 (sr) 2010-11-12 2021-06-30 Nektar Therapeutics Konjugati il-2 dela i polimera
US9266937B2 (en) 2010-12-10 2016-02-23 University Of Central Florida Research Foundation, Inc. Compositions comprising IL-7 receptor ligands
BR112013018046B1 (pt) 2011-01-18 2023-01-31 Bioniz, Llc Conjugado peptídico, composição farmacêutica, métodos in vitro para bloquear sinalização por um ou mais membros de família citocina-yc e para inibir ligação de citocina-yc a subunidade-yc e uso de conjugado peptídico ou de composição farmacêutica
EP3134102B1 (en) 2014-04-24 2019-07-03 The Board of Trustees of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
SG11201700514SA (en) 2014-07-21 2017-02-27 Delinia Inc Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
ES2710618T3 (es) 2015-08-06 2019-04-26 Agency Science Tech & Res Anticuerpos frente a IL2R-Beta/cadena gamma común
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
CN109071679B (zh) 2016-02-05 2023-07-28 华盛顿大学 用于靶向的细胞因子递送的组合物和方法
WO2018089420A1 (en) 2016-11-08 2018-05-17 Delinia, Inc. Il-2 variants for the treatment of autoimmune diseases
US10472405B2 (en) 2016-12-13 2019-11-12 Delinia, Inc. Multivalent regulatory T cell modulators
CN112585160A (zh) 2018-08-06 2021-03-30 麦地金公司 Il-2受体结合化合物

Also Published As

Publication number Publication date
CA3169452A1 (en) 2021-08-12
US11254729B2 (en) 2022-02-22
EP4100046A4 (en) 2024-03-06
JP2023512687A (ja) 2023-03-28
TWI823054B (zh) 2023-11-21
KR20220156533A (ko) 2022-11-25
TW202142559A (zh) 2021-11-16
US20210253669A1 (en) 2021-08-19
US20220119493A1 (en) 2022-04-21
AU2021217959A1 (en) 2022-08-18
WO2021158619A1 (en) 2021-08-12
CN115297886A (zh) 2022-11-04
MX2022009302A (es) 2022-11-16
IL295303A (en) 2022-10-01
EP4100046A1 (en) 2022-12-14
WO2021158619A8 (en) 2022-04-28

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