MX2022005270A - Derivados de quinolina y quinoxalina fluoradas como inhibidores de dihidroorotato deshidrogenasa (dhodh) para el tratamiento del cancer, enfermedades autoinmunes e inflamatorias. - Google Patents
Derivados de quinolina y quinoxalina fluoradas como inhibidores de dihidroorotato deshidrogenasa (dhodh) para el tratamiento del cancer, enfermedades autoinmunes e inflamatorias.Info
- Publication number
- MX2022005270A MX2022005270A MX2022005270A MX2022005270A MX2022005270A MX 2022005270 A MX2022005270 A MX 2022005270A MX 2022005270 A MX2022005270 A MX 2022005270A MX 2022005270 A MX2022005270 A MX 2022005270A MX 2022005270 A MX2022005270 A MX 2022005270A
- Authority
- MX
- Mexico
- Prior art keywords
- dhodh
- inhibitors
- cancer
- treatment
- autoimmune
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
La presente invención describe compuestos de la Fórmula (I): (?) en donde X es CH; Los presentes compuestos de la Fórmula (I) son inhibidores de dihidroorotato deshidrogenasa (DHODH) y son útiles para el tratamiento de trastornos inflamatorios, trastornos autoinmunes y cáncer, tales como, p. ej., linfomas, leucemias, carcinomas y sarcomas. La presente descripción describe la síntesis y caracterización de compuestos ilustrativos así como datos farmacológicos de estos (p. ej., páginas 60 a 136; ejemplos 1 al 39; tablas 1 y 2). Un compuesto ilustrativo es, p. ej.: 4-etil-1-(7-fluoro-4-isopropil-2- (2-metoxifenil)quinolin-6-il)-3- (hidroximetil)-1H-1,2,4-triazol-5(4H)-ona (ejemplo 1): (AA).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962929163P | 2019-11-01 | 2019-11-01 | |
PCT/IB2020/060221 WO2021084500A1 (en) | 2019-11-01 | 2020-10-30 | Fluorinated quinoline and quinoxaline derivatives as dihydroorotate dehydrogenase (dhodh) inhibitors for the treatment of cancer, autoimmune and inflammatory diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022005270A true MX2022005270A (es) | 2022-06-09 |
Family
ID=73198375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022005270A MX2022005270A (es) | 2019-11-01 | 2020-10-30 | Derivados de quinolina y quinoxalina fluoradas como inhibidores de dihidroorotato deshidrogenasa (dhodh) para el tratamiento del cancer, enfermedades autoinmunes e inflamatorias. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230037448A1 (es) |
EP (1) | EP4051672A1 (es) |
JP (1) | JP2023500252A (es) |
KR (1) | KR20220097438A (es) |
CN (1) | CN114650988A (es) |
AU (1) | AU2020377205A1 (es) |
BR (1) | BR112022007981A2 (es) |
CA (1) | CA3159578A1 (es) |
MX (1) | MX2022005270A (es) |
WO (1) | WO2021084500A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3184985A1 (en) * | 2020-07-14 | 2022-01-20 | Nanjing Zenshine Pharmaceuticals Co., Ltd. | Compounds as dhodh inhibitors |
WO2022200615A1 (en) | 2021-03-26 | 2022-09-29 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Pyrimidine biosynthesis inhibitor combination for use in treating viral infections |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009544631A (ja) * | 2006-07-25 | 2009-12-17 | エンビボ ファーマシューティカルズ インコーポレイテッド | キノリン誘導体 |
EP2113503A1 (en) * | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
JP2014522837A (ja) * | 2011-06-29 | 2014-09-08 | 大塚製薬株式会社 | 治療用化合物としてのキナゾリン及び関連の使用方法 |
KR102029124B1 (ko) * | 2015-08-27 | 2019-10-07 | 화이자 인코포레이티드 | Irak4 조정제로서의 비시클릭-융합된 헤테로아릴 또는 아릴 화합물 |
EP3553052A1 (en) * | 2018-04-10 | 2019-10-16 | Bayer AG | 5-oxo-4,5-dihydro-1h-1,2,4-triazol derivatives for the treatment of cancer |
-
2020
- 2020-10-30 US US17/773,098 patent/US20230037448A1/en active Pending
- 2020-10-30 MX MX2022005270A patent/MX2022005270A/es unknown
- 2020-10-30 AU AU2020377205A patent/AU2020377205A1/en active Pending
- 2020-10-30 EP EP20803940.4A patent/EP4051672A1/en active Pending
- 2020-10-30 JP JP2022525153A patent/JP2023500252A/ja active Pending
- 2020-10-30 KR KR1020227018271A patent/KR20220097438A/ko active Search and Examination
- 2020-10-30 WO PCT/IB2020/060221 patent/WO2021084500A1/en unknown
- 2020-10-30 CN CN202080077544.1A patent/CN114650988A/zh active Pending
- 2020-10-30 BR BR112022007981A patent/BR112022007981A2/pt not_active Application Discontinuation
- 2020-10-30 CA CA3159578A patent/CA3159578A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2021084500A1 (en) | 2021-05-06 |
CA3159578A1 (en) | 2021-05-06 |
AU2020377205A1 (en) | 2022-06-16 |
US20230037448A1 (en) | 2023-02-09 |
EP4051672A1 (en) | 2022-09-07 |
CN114650988A (zh) | 2022-06-21 |
BR112022007981A2 (pt) | 2022-07-05 |
JP2023500252A (ja) | 2023-01-05 |
KR20220097438A (ko) | 2022-07-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7317028B2 (ja) | 抗ガン剤として有用な置換キナゾリン誘導体と置換ピリドピリミジン誘導体 | |
MX2022005270A (es) | Derivados de quinolina y quinoxalina fluoradas como inhibidores de dihidroorotato deshidrogenasa (dhodh) para el tratamiento del cancer, enfermedades autoinmunes e inflamatorias. | |
MY148986A (en) | Heterocyclic janus kinase 3 inhibitors | |
US4912106A (en) | 5,6-Dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5,(2H,4H)-diones and their use as protozoa combating agents | |
MA27801A1 (fr) | Nouveaux composes heterocycliques pour le traitement des affections inflammatoires et allergiques, leur procede de preparation et compositions pharmaceutiques les contenant | |
ATE503483T1 (de) | Hemmer der akt aktivität | |
HRP20050533A2 (en) | Aminoindazole derivatives and use thereof as kinase inhibitors | |
RU2008112691A (ru) | Азотсодержащее гетероциклическое соединение и его фармацевтическое применение | |
US7019002B2 (en) | Pyridopyrimidinones derivatives as telomerase inhibitors | |
ATE446752T1 (de) | Hemmer der akt aktivität | |
CR8148A (es) | Derivados del indazolil (indolil) maleimida sustituidos como inhibidores de la cinasa | |
ATE461179T1 (de) | Hemmer der akt aktivität | |
CR20210626A (es) | Compuestos para el tratamiento de enfermedades y trastornos asociados con braf | |
FI90235B (fi) | Menetelmä eläinlääketieteellisesti käyttökelpoisten -aryyli-4-(4,5-dihydro-3,5-diokso-1,2,4-triatsin-2(3H)-yyli)bentseeniasetonitriilien valmistamiseksi | |
MX2022005258A (es) | Derivados de benzo[b][1,4]oxazina, quinoxalina y quinolona fluoradas como inhibidores de dihidroorotato deshidrogenasa (dhodh) para el tratamiento del cancer, enfermedades autoinmunes e inflamatorias. | |
ATE307810T1 (de) | Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren | |
MA54133A (fr) | Composés d'aminopyrazine diol utilisés comme inhibiteurs de pi3k-y | |
NO20063747L (no) | Substituerte kinoliner og deres anvendelse som mykobakterielle inhibitorer | |
CL2023001461A1 (es) | Inhibidores de prmt5 novedosos | |
US9120780B2 (en) | Indole or indazole derivative or salt thereof | |
KR101894096B1 (ko) | Jnk 저해 활성을 갖는 신규한 이미다졸 유도체 및 이의 용도 | |
JPWO2019235553A5 (es) | ||
HUP0401115A2 (hu) | Szívbetegségek és allergiák kezelésére alkalmas, PDE IV-gátló és TNF-antagonista hatású 4-(benzilidén-amino)-3-(metil-szulfanil)-4H-[1,2,4]triazin-5-on-származékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények | |
EA202191349A1 (ru) | 1,3,4-оксадиазолон и фармацевтический препарат | |
MEP25308A (en) | Aminoindazole derivatives and use thereof as kinase inhibitors |