MX2022000934A - Composiciones estables de nanoparticulas lipidicas cargadas de arnm y procesos de fabricacion. - Google Patents
Composiciones estables de nanoparticulas lipidicas cargadas de arnm y procesos de fabricacion.Info
- Publication number
- MX2022000934A MX2022000934A MX2022000934A MX2022000934A MX2022000934A MX 2022000934 A MX2022000934 A MX 2022000934A MX 2022000934 A MX2022000934 A MX 2022000934A MX 2022000934 A MX2022000934 A MX 2022000934A MX 2022000934 A MX2022000934 A MX 2022000934A
- Authority
- MX
- Mexico
- Prior art keywords
- mrna
- processes
- lipid nanoparticles
- making
- loaded lipid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Optics & Photonics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención proporciona composiciones y procesos mejorados para preparar nanopartículas lipídicas cargadas de ARNm (ARNm-LNP); en algunas modalidades, la presente invención proporciona ARNm-LNP con una estabilidad excepcional y es particularmente útil en los casos en los que se desean LNP que comprenden un contenido bajo o nulo de lípidos modificados con PEG.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962877597P | 2019-07-23 | 2019-07-23 | |
PCT/US2020/043223 WO2021016430A1 (en) | 2019-07-23 | 2020-07-23 | Stable compositions of mrna-loaded lipid nanoparticles and processes of making |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022000934A true MX2022000934A (es) | 2022-02-14 |
Family
ID=72088362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022000934A MX2022000934A (es) | 2019-07-23 | 2020-07-23 | Composiciones estables de nanoparticulas lipidicas cargadas de arnm y procesos de fabricacion. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20210046192A1 (es) |
EP (1) | EP4003311A1 (es) |
JP (1) | JP2022542562A (es) |
KR (1) | KR20220038365A (es) |
CN (1) | CN114401748A (es) |
AU (1) | AU2020315962A1 (es) |
BR (1) | BR112022001192A2 (es) |
CA (1) | CA3146675A1 (es) |
IL (2) | IL289944A (es) |
MX (1) | MX2022000934A (es) |
WO (1) | WO2021016430A1 (es) |
Families Citing this family (32)
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CN110167587A (zh) | 2016-11-11 | 2019-08-23 | 摩登纳特斯有限公司 | 流感疫苗 |
EP3609534A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | BROAD SPECTRUM VACCINE AGAINST THE INFLUENZA VIRUS |
EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
JP7275111B2 (ja) | 2017-08-31 | 2023-05-17 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子の生成方法 |
MA54676A (fr) | 2018-01-29 | 2021-11-17 | Modernatx Inc | Vaccins à base d'arn contre le vrs |
CN113166783A (zh) | 2018-10-09 | 2021-07-23 | 不列颠哥伦比亚大学 | 包含无有机溶剂和去污剂的转染活性囊泡的组合物和***以及与之相关的方法 |
TW202139976A (zh) * | 2020-01-31 | 2021-11-01 | 美商現代公司 | 製備脂質奈米顆粒之方法 |
EP4149425A1 (en) * | 2020-05-15 | 2023-03-22 | Translate Bio, Inc. | Lipid nanoparticle formulations for mrna delivery |
US11771652B2 (en) | 2020-11-06 | 2023-10-03 | Sanofi | Lipid nanoparticles for delivering mRNA vaccines |
IL303195A (en) | 2020-11-25 | 2023-07-01 | Akagera Medicines Inc | Lipid nanoparticles for delivery of nucleic acids and related methods of use |
JP2024509743A (ja) * | 2021-02-16 | 2024-03-05 | ザ・ジョンズ・ホプキンス・ユニバーシティ | in vitroおよびin vivoトランスフェクションのための規定サイズのプラスミドDNA/脂質粒子の調製方法 |
CN113509542A (zh) * | 2021-04-20 | 2021-10-19 | 嘉晨西海(杭州)生物技术有限公司 | 一种基于mRNA的表达白介素12针对肿瘤的药物及其制备方法 |
EP4326227A1 (en) * | 2021-04-23 | 2024-02-28 | ModernaTX, Inc. | Stabilized formulations |
EP4326241A1 (en) * | 2021-04-23 | 2024-02-28 | ModernaTX, Inc. | Isoquinoline-stabilized lipid nanoparticle formulations |
KR20240049810A (ko) | 2021-09-03 | 2024-04-17 | 큐어백 에스이 | 핵산 전달용 신규 지질 나노입자 |
KR20230053998A (ko) | 2021-10-15 | 2023-04-24 | (주)지노믹트리 | mRNA 발현을 위한 유전자 구조체 |
WO2023073228A1 (en) | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
IL312334A (en) | 2021-11-05 | 2024-06-01 | Sanofi Sa | RNA vaccine for respiratory syncytial virus |
CA3239417A1 (en) | 2021-11-30 | 2023-06-08 | Yvonne CHAN | Human metapneumovirus vaccines |
WO2023114307A1 (en) * | 2021-12-15 | 2023-06-22 | Modernatx, Inc. | Determination of encapsulation efficiency of lipid nanoparticles |
WO2023111262A1 (en) | 2021-12-17 | 2023-06-22 | Sanofi | Lyme disease rna vaccine |
CN116549626A (zh) * | 2022-01-27 | 2023-08-08 | 深圳瑞吉生物科技有限公司 | 一种载核酸脂质纳米颗粒冻干制剂及其制备方法与应用 |
WO2023144330A1 (en) | 2022-01-28 | 2023-08-03 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
WO2023156487A1 (en) | 2022-02-15 | 2023-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for modulating tear film composition to treat corneal defects |
WO2023227608A1 (en) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
WO2024028492A1 (en) | 2022-08-04 | 2024-02-08 | Sanofi | Quantitative assessment of rna encapsulation |
WO2024057237A1 (en) * | 2022-09-16 | 2024-03-21 | Pfizer Inc. | Lipid nanoparticles |
DE202023106198U1 (de) | 2022-10-28 | 2024-03-21 | CureVac SE | Impfstoff auf Nukleinsäurebasis |
WO2024094027A1 (zh) * | 2022-11-03 | 2024-05-10 | 深圳鸿生生物科技有限公司 | 用于增强核酸递送的组合物 |
WO2024094881A1 (en) | 2022-11-04 | 2024-05-10 | Sanofi | Respiratory syncytial virus rna vaccination |
WO2024112717A1 (en) * | 2022-11-21 | 2024-05-30 | Avstera Therapeutics Corp. | Mrna composition for preventing and treating cancer |
WO2024133515A1 (en) | 2022-12-20 | 2024-06-27 | Sanofi | Rhinovirus mrna vaccine |
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2020
- 2020-07-23 EP EP20757429.4A patent/EP4003311A1/en active Pending
- 2020-07-23 KR KR1020227003695A patent/KR20220038365A/ko unknown
- 2020-07-23 CA CA3146675A patent/CA3146675A1/en active Pending
- 2020-07-23 WO PCT/US2020/043223 patent/WO2021016430A1/en unknown
- 2020-07-23 AU AU2020315962A patent/AU2020315962A1/en active Pending
- 2020-07-23 JP JP2022504132A patent/JP2022542562A/ja active Pending
- 2020-07-23 CN CN202080065024.9A patent/CN114401748A/zh active Pending
- 2020-07-23 BR BR112022001192A patent/BR112022001192A2/pt unknown
- 2020-07-23 US US16/936,909 patent/US20210046192A1/en active Pending
- 2020-07-23 MX MX2022000934A patent/MX2022000934A/es unknown
-
2022
- 2022-01-13 IL IL289944A patent/IL289944A/en unknown
- 2022-01-13 IL IL289984A patent/IL289984A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN114401748A (zh) | 2022-04-26 |
IL289984A (en) | 2022-03-01 |
IL289944A (en) | 2022-04-01 |
BR112022001192A2 (pt) | 2022-03-15 |
KR20220038365A (ko) | 2022-03-28 |
US20210046192A1 (en) | 2021-02-18 |
EP4003311A1 (en) | 2022-06-01 |
CA3146675A1 (en) | 2021-01-28 |
JP2022542562A (ja) | 2022-10-05 |
AU2020315962A1 (en) | 2022-02-03 |
WO2021016430A1 (en) | 2021-01-28 |
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