MX2021014710A - Un conjugado inmunogenico de polisacarido de neumococo del serotipo 35b- proteina y proceso de conjugacion para preparar el mismo. - Google Patents
Un conjugado inmunogenico de polisacarido de neumococo del serotipo 35b- proteina y proceso de conjugacion para preparar el mismo.Info
- Publication number
- MX2021014710A MX2021014710A MX2021014710A MX2021014710A MX2021014710A MX 2021014710 A MX2021014710 A MX 2021014710A MX 2021014710 A MX2021014710 A MX 2021014710A MX 2021014710 A MX2021014710 A MX 2021014710A MX 2021014710 A MX2021014710 A MX 2021014710A
- Authority
- MX
- Mexico
- Prior art keywords
- serotype
- making
- same
- protein conjugate
- pneumococcal polysaccharide
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención proporciona una mejora de proceso relacionada con la conjugación de polisacáridos capsulares de Streptococcus pneumoniae (S. pneumoniae) serotipo 35B a una proteína transportadora. El conjugado de polisacárido de serotipo 35B-proteína, preparado por el proceso descrito, es, entre otras cosas, más inmunogénico que los conjugados similares hechos por métodos de la técnica anterior. Los conjugados de polisacárido de S. pneumoniae serotipo 35B-proteína preparados usando los procesos de la invención pueden incluirse en composiciones de vacuna neumocócica conjugada multivalente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962857524P | 2019-06-05 | 2019-06-05 | |
PCT/US2020/035509 WO2020247299A1 (en) | 2019-06-05 | 2020-06-01 | An immunogenic serotype 35b pneumococcal polysaccharide-protein conjugate and conjugation process for making the same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021014710A true MX2021014710A (es) | 2022-01-18 |
Family
ID=73652261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021014710A MX2021014710A (es) | 2019-06-05 | 2020-06-01 | Un conjugado inmunogenico de polisacarido de neumococo del serotipo 35b- proteina y proceso de conjugacion para preparar el mismo. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220233674A1 (es) |
EP (1) | EP3980055A4 (es) |
JP (1) | JP2022535063A (es) |
KR (1) | KR20220017996A (es) |
CN (1) | CN114025790A (es) |
AU (1) | AU2020286360A1 (es) |
BR (1) | BR112021024393A8 (es) |
CA (1) | CA3142692A1 (es) |
MX (1) | MX2021014710A (es) |
WO (1) | WO2020247299A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018144439A1 (en) | 2017-01-31 | 2018-08-09 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
CN110337307A (zh) | 2017-02-24 | 2019-10-15 | 默沙东公司 | 增强肺炎链球菌多糖-蛋白缀合物的免疫原性 |
JP7218358B2 (ja) | 2017-09-07 | 2023-02-06 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖体および免疫原性多糖体-キャリアタンパク質コンジュゲートでのその使用 |
CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
JP7369123B2 (ja) | 2017-12-06 | 2023-10-25 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖類-タンパク質コンジュゲートを含む組成物およびその使用方法 |
KR20210002641A (ko) | 2018-04-30 | 2021-01-08 | 머크 샤프 앤드 돔 코포레이션 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
KR20210005158A (ko) | 2018-04-30 | 2021-01-13 | 머크 샤프 앤드 돔 코포레이션 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 담체 단백질 접합체를 제조하는 방법 |
MA54533A (fr) | 2018-12-19 | 2022-03-30 | Merck Sharp & Dohme | Compositions comprenant des conjugués polysaccharide-protéine de streptococcus pneumoniae et leurs méthodes d'utilisation |
WO2023135515A1 (en) | 2022-01-13 | 2023-07-20 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
US10668164B2 (en) * | 2014-02-14 | 2020-06-02 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
US10729780B2 (en) * | 2015-06-08 | 2020-08-04 | Serum Institute Of India Private Ltd. | Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof |
UA126385C2 (uk) * | 2016-09-30 | 2022-09-28 | Байолоджикал І Лімітед | Композиції полівалентної пневмококової вакцини, що містять кон'югати полісахарид-білок |
CN110337307A (zh) * | 2017-02-24 | 2019-10-15 | 默沙东公司 | 增强肺炎链球菌多糖-蛋白缀合物的免疫原性 |
KR102634811B1 (ko) * | 2017-06-10 | 2024-02-06 | 인벤트프라이즈 인크. | 면역원성과 항원항체 결합성이 개선된 2가 또는 다가 접합체 다당류를 가진 다가 접합체 백신 |
WO2020157772A1 (en) * | 2019-01-28 | 2020-08-06 | Biological E Limited | Multivalent pneumococcal polysaccharide-protein conjugate vaccine compositions |
-
2020
- 2020-06-01 MX MX2021014710A patent/MX2021014710A/es unknown
- 2020-06-01 US US17/614,865 patent/US20220233674A1/en active Pending
- 2020-06-01 AU AU2020286360A patent/AU2020286360A1/en active Pending
- 2020-06-01 CN CN202080049161.3A patent/CN114025790A/zh active Pending
- 2020-06-01 CA CA3142692A patent/CA3142692A1/en active Pending
- 2020-06-01 KR KR1020227000139A patent/KR20220017996A/ko unknown
- 2020-06-01 WO PCT/US2020/035509 patent/WO2020247299A1/en unknown
- 2020-06-01 BR BR112021024393A patent/BR112021024393A8/pt unknown
- 2020-06-01 EP EP20819583.4A patent/EP3980055A4/en active Pending
- 2020-06-01 JP JP2021571698A patent/JP2022535063A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2020286360A1 (en) | 2021-12-23 |
KR20220017996A (ko) | 2022-02-14 |
BR112021024393A8 (pt) | 2023-01-31 |
EP3980055A1 (en) | 2022-04-13 |
EP3980055A4 (en) | 2023-07-26 |
JP2022535063A (ja) | 2022-08-04 |
CA3142692A1 (en) | 2020-12-10 |
BR112021024393A2 (pt) | 2022-01-18 |
CN114025790A (zh) | 2022-02-08 |
WO2020247299A1 (en) | 2020-12-10 |
US20220233674A1 (en) | 2022-07-28 |
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