MX2021007934A - Dispositivo integrado para el depósito temporal de fotones recibidos. - Google Patents
Dispositivo integrado para el depósito temporal de fotones recibidos.Info
- Publication number
- MX2021007934A MX2021007934A MX2021007934A MX2021007934A MX2021007934A MX 2021007934 A MX2021007934 A MX 2021007934A MX 2021007934 A MX2021007934 A MX 2021007934A MX 2021007934 A MX2021007934 A MX 2021007934A MX 2021007934 A MX2021007934 A MX 2021007934A
- Authority
- MX
- Mexico
- Prior art keywords
- integrated device
- charge carriers
- integrated circuit
- received photons
- charge
- Prior art date
Links
- 230000002123 temporal effect Effects 0.000 title 1
- 239000002800 charge carrier Substances 0.000 abstract 7
- 238000005204 segregation Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
- H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
- H01L27/144—Devices controlled by radiation
- H01L27/146—Imager structures
- H01L27/14601—Structural or functional details thereof
- H01L27/14603—Special geometry or disposition of pixel-elements, address-lines or gate-electrodes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
- G01S7/483—Details of pulse systems
- G01S7/486—Receivers
- G01S7/4865—Time delay measurement, e.g. time-of-flight measurement, time of arrival measurement or determining the exact position of a peak
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
- H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
- H01L27/144—Devices controlled by radiation
- H01L27/146—Imager structures
- H01L27/14683—Processes or apparatus peculiar to the manufacture or treatment of these devices or parts thereof
- H01L27/14687—Wafer level processing
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
- H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
- H01L27/144—Devices controlled by radiation
- H01L27/146—Imager structures
- H01L27/148—Charge coupled imagers
- H01L27/14806—Structural or functional details thereof
- H01L27/14812—Special geometry or disposition of pixel-elements, address lines or gate-electrodes
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
- H04N25/70—SSIS architectures; Circuits associated therewith
- H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
- H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
- H04N25/70—SSIS architectures; Circuits associated therewith
- H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
- H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
- H04N25/771—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising storage means other than floating diffusion
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N25/00—Circuitry of solid-state image sensors [SSIS]; Control thereof
- H04N25/70—SSIS architectures; Circuits associated therewith
- H04N25/76—Addressed sensors, e.g. MOS or CMOS sensors
- H04N25/77—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components
- H04N25/772—Pixel circuitry, e.g. memories, A/D converters, pixel amplifiers, shared circuits or shared components comprising A/D, V/T, V/F, I/T or I/F converters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/069—Supply of sources
- G01N2201/0696—Pulsed
- G01N2201/0697—Pulsed lasers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S17/00—Systems using the reflection or reradiation of electromagnetic waves other than radio waves, e.g. lidar systems
- G01S17/88—Lidar systems specially adapted for specific applications
- G01S17/89—Lidar systems specially adapted for specific applications for mapping or imaging
- G01S17/894—3D imaging with simultaneous measurement of time-of-flight at a 2D array of receiver pixels, e.g. time-of-flight cameras or flash lidar
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/48—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S17/00
- G01S7/483—Details of pulse systems
- G01S7/486—Receivers
- G01S7/4861—Circuits for detection, sampling, integration or read-out
- G01S7/4863—Detector arrays, e.g. charge-transfer gates
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Power Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Electromagnetism (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Computer Hardware Design (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Signal Processing (AREA)
- Multimedia (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Computer Networks & Wireless Communication (AREA)
- Radar, Positioning & Navigation (AREA)
- Remote Sensing (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Transforming Light Signals Into Electric Signals (AREA)
- Solid State Image Pick-Up Elements (AREA)
Abstract
Un circuito integrado incluye una región de fotodetección configurada para recibir fotones incidentes; la región de fotodetección se configura para producir una pluralidad de portadores de carga en respuesta a los fotones incidentes; el circuito integrado también incluye al menos una región de almacenamiento de portador de carga; el circuito integrado también incluye una estructura de segregación de portador de carga configurada para dirigir selectivamente los portadores de carga de la pluralidad de portadores de carga en la al menos una región de almacenamiento de portador de carga con base en los tiempos en los que se producen los portadores de carga.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462035377P | 2014-08-08 | 2014-08-08 | |
US201562164506P | 2015-05-20 | 2015-05-20 | |
PCT/US2015/044360 WO2016022998A2 (en) | 2014-08-08 | 2015-08-07 | Integrated device for temporal binning of received photons |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021007934A true MX2021007934A (es) | 2023-01-17 |
Family
ID=54064569
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007934A MX2021007934A (es) | 2014-08-08 | 2015-08-07 | Dispositivo integrado para el depósito temporal de fotones recibidos. |
MX2017001806A MX2017001806A (es) | 2014-08-08 | 2015-08-07 | Dispositivo integrado para el depósito temporal de fotones recibidos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017001806A MX2017001806A (es) | 2014-08-08 | 2015-08-07 | Dispositivo integrado para el depósito temporal de fotones recibidos. |
Country Status (10)
Country | Link |
---|---|
US (8) | US9759658B2 (es) |
EP (2) | EP3471402B1 (es) |
JP (2) | JP6707520B2 (es) |
KR (3) | KR102452571B1 (es) |
CN (2) | CN111710687B (es) |
AU (2) | AU2015300766B2 (es) |
BR (1) | BR112017002485B1 (es) |
CA (1) | CA2957540A1 (es) |
MX (2) | MX2021007934A (es) |
WO (1) | WO2016022998A2 (es) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2930836A1 (en) | 2013-11-17 | 2015-05-21 | Quantum-Si Incorporated | Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens |
MX2017001808A (es) | 2014-08-08 | 2018-02-08 | Quantum Si Inc | Dispositivo integrado con fuente de luz externa para el sondeo, deteccion y analisis de moleculas. |
US9759658B2 (en) | 2014-08-08 | 2017-09-12 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
WO2016023010A1 (en) | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting, and analyzing molecules |
KR101725099B1 (ko) * | 2014-12-05 | 2017-04-26 | 삼성전자주식회사 | 컴퓨터 단층 촬영장치 및 그 제어방법 |
US10174363B2 (en) | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
AU2015203591A1 (en) * | 2015-06-26 | 2017-01-19 | Canon Kabushiki Kaisha | System and method for object matching |
JP2017098809A (ja) * | 2015-11-26 | 2017-06-01 | キヤノン株式会社 | 光電変換装置、および、撮像システム |
CA3012705A1 (en) * | 2016-02-17 | 2017-08-24 | Tesseract Health, Inc. | Sensor and device for lifetime imaging and detection applications |
CN109313925B (zh) * | 2016-06-01 | 2022-09-02 | 宽腾矽公司 | 脉冲命名器及基质命名器 |
CN109155322B (zh) * | 2016-06-08 | 2023-02-21 | 因维萨热技术公司 | 具有电子快门的图像传感器 |
JP6908819B2 (ja) * | 2016-09-29 | 2021-07-28 | ミツミ電機株式会社 | 近接センサ |
EP3305170B1 (en) * | 2016-10-04 | 2020-12-02 | ams AG | Fluorescence lifetime sensor module and method of determining a fluorescence lifetime using a sensor module |
JP6808463B2 (ja) * | 2016-11-30 | 2021-01-06 | キヤノン株式会社 | 光電変換装置および光電変換システム |
BR112019012414A2 (pt) | 2016-12-19 | 2020-02-27 | Quantum-Si Incorporated | Carregamento de moléculas em poços de amostra para análise |
CN110168732B (zh) * | 2016-12-22 | 2024-03-08 | 宽腾矽公司 | 具有直接合并像素的整合式光电侦测器 |
GB201622429D0 (en) * | 2016-12-30 | 2017-02-15 | Univ Court Of The Univ Of Edinburgh The | Photon sensor apparatus |
KR20200004849A (ko) | 2017-05-05 | 2020-01-14 | 퀀텀-에스아이 인코포레이티드 | 생물학적 반응에 있어서 개질된 표면 반응성 및 오손방지 특성을 갖는 기재 |
CN111133294B (zh) * | 2017-07-24 | 2024-05-24 | 宽腾矽公司 | 光抑制光子结构 |
CN111566261A (zh) | 2017-08-18 | 2020-08-21 | 诺迪勒思生物科技公司 | 选择结合试剂的方法 |
WO2019084537A1 (en) * | 2017-10-29 | 2019-05-02 | Rourk Christopher J | ELECTRON TRANSPORT DOOR CIRCUITS AND METHODS OF MANUFACTURE, OPERATION AND USE |
US10817780B2 (en) | 2017-10-29 | 2020-10-27 | Christopher J. Rourk | Electron transport gate circuits and methods of manufacture, operation and use |
EP3813356A1 (en) | 2017-10-30 | 2021-04-28 | Sony Semiconductor Solutions Corporation | Solid-state imaging device |
JP2021511829A (ja) * | 2018-01-26 | 2021-05-13 | クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated | シークエンシングデバイスに関する機械学習可能なパルス決定および塩基決定 |
US11808700B2 (en) * | 2018-06-15 | 2023-11-07 | Quantum-Si Incorporated | Data acquisition control for advanced analytic instruments having pulsed optical sources |
AU2019288394A1 (en) * | 2018-06-22 | 2021-01-07 | Quantum-Si Incorporated | Integrated photodetector with charge storage bin of varied detection time |
JP7419336B2 (ja) | 2018-07-16 | 2024-01-22 | ギガジョット テクノロジー,インコーポレイテッド | 非アバランシェ光検出器を有する高感度深度センサ |
CN108760641B (zh) * | 2018-08-17 | 2023-05-16 | 龙岩学院 | 基于单光子探测的熔焊过程监测装置及监测方法 |
BR112021003146A2 (pt) * | 2018-08-29 | 2021-05-11 | Quantum-Si Incorporated | sistema e métodos para detectar o tempo de vida ao usar fotodetectores de contagem de fótons |
JP2020072317A (ja) * | 2018-10-30 | 2020-05-07 | ソニーセミコンダクタソリューションズ株式会社 | センサ及び制御方法 |
EP3881078A1 (en) | 2018-11-15 | 2021-09-22 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
WO2020106889A1 (en) | 2018-11-20 | 2020-05-28 | Nautilus Biotechnology, Inc. | Design and selection of affinity reagents |
US11607119B2 (en) | 2018-12-17 | 2023-03-21 | Qatar University | Fluorescence lifetime spectroscopy based capsule endoscopy |
DE102018222118A1 (de) * | 2018-12-18 | 2020-06-18 | Robert Bosch Gmbh | CCD-Photodetektor und zugehöriges Verfahren zum Betrieb |
US11423306B2 (en) * | 2019-05-16 | 2022-08-23 | Illumina, Inc. | Systems and devices for characterization and performance analysis of pixel-based sequencing |
CN114174858A (zh) * | 2019-07-12 | 2022-03-11 | 索尼半导体解决方案公司 | 半导体装置 |
BR112022006682A2 (pt) | 2019-10-11 | 2022-07-12 | Quantum Si Inc | Modificação de superfície na fase de vapor |
CN110579460B (zh) * | 2019-10-14 | 2023-04-18 | 深圳大学 | 一种寻址扫描快速荧光寿命显微成像***及方法 |
CA3159566A1 (en) | 2019-10-29 | 2021-05-06 | Quantum-Si Incorporated | Peristaltic pumping of fluids and associated methods, systems, and devices |
US11885744B2 (en) | 2020-01-14 | 2024-01-30 | Quantum-Si Incorporated | Sensor for lifetime plus spectral characterization |
US11869917B2 (en) | 2020-01-14 | 2024-01-09 | Quantum-Si Incorporated | Integrated sensor for lifetime characterization |
WO2021146346A1 (en) * | 2020-01-14 | 2021-07-22 | Quantum-Si Incorporated | Amplitude-modulated laser |
EP4111178A1 (en) * | 2020-03-02 | 2023-01-04 | Quantum-si Incorporated | Integrated sensor for multi-dimensional signal analysis |
EP4133524A2 (en) * | 2020-04-08 | 2023-02-15 | Quantum-si Incorporated | Integrated sensor with reduced skew |
US11532150B1 (en) * | 2020-06-02 | 2022-12-20 | Honeywell Federal Manufacturing & Technologies, Llc | Method for determining a histogram of variable sample rate waveforms |
AU2021288692A1 (en) | 2020-06-11 | 2023-02-02 | Nautilus Subsidiary, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
IL302221A (en) * | 2020-10-22 | 2023-06-01 | Quantum Si Inc | An integrated circuit with series-coupled charge storage and related techniques |
JP2023548817A (ja) * | 2020-10-27 | 2023-11-21 | クアンタム-エスアイ インコーポレイテッド | 単一分子検出システムの較正 |
CA3204999A1 (en) * | 2020-12-11 | 2022-06-16 | Quantum-Si Incorporated | Integrated circuit with improved charge transfer efficiency and associated techniques |
AU2022209365A1 (en) | 2021-01-21 | 2023-07-20 | Nautilus Subsidiary, Inc. | Systems and methods for biomolecule preparation |
US11505796B2 (en) | 2021-03-11 | 2022-11-22 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule retention |
CN113268142B (zh) * | 2021-06-09 | 2024-04-02 | 江苏集萃脑机融合智能技术研究所有限公司 | 基于直接测量飞行时间技术的脑机接口***、脑机接口穿戴设备及其控制方法 |
EP4399528A1 (en) | 2021-09-09 | 2024-07-17 | Nautilus Subsidiary, Inc. | Characterization and localization of protein modifications |
CA3227592A1 (en) | 2021-09-22 | 2023-03-30 | Gregory KAPP | Methods and systems for determining polypeptide interactions |
WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
WO2023192917A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
WO2024019988A1 (en) * | 2022-07-18 | 2024-01-25 | Cellsbin, Inc. | Devices for biological analysis |
WO2024039853A1 (en) * | 2022-08-19 | 2024-02-22 | Quantum-Si Incorporated | Backside illuminated structures with parallel charge transfer |
WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
US20240192202A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | Fluidic media for single-analtye arrays |
US20240201182A1 (en) | 2022-12-15 | 2024-06-20 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
WO2024138630A1 (zh) * | 2022-12-30 | 2024-07-04 | 深圳华大智造科技股份有限公司 | 基因数据的编码和解码方法、装置及基因检测*** |
Family Cites Families (215)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
EP0450060A1 (en) | 1989-10-26 | 1991-10-09 | Sri International | Dna sequencing |
US5355165A (en) | 1992-08-06 | 1994-10-11 | Princeton Scientific Instruments, Inc. | Very high frame rate CCD imager |
EP0682671A4 (en) | 1993-02-01 | 1998-01-14 | Seq Ltd | METHOD AND DEVICES FOR SEQUENCING DNA. |
US5471515A (en) | 1994-01-28 | 1995-11-28 | California Institute Of Technology | Active pixel sensor with intra-pixel charge transfer |
US6456326B2 (en) | 1994-01-28 | 2002-09-24 | California Institute Of Technology | Single chip camera device having double sampling operation |
CZ347196A3 (en) | 1994-05-27 | 1997-06-11 | Ciba Geigy Ag | Method of detecting evanescently excited luminescence |
US5912155A (en) | 1994-09-30 | 1999-06-15 | Life Technologies, Inc. | Cloned DNA polymerases from Thermotoga neapolitana |
US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
US6261797B1 (en) | 1996-01-29 | 2001-07-17 | Stratagene | Primer-mediated polynucleotide synthesis and manipulation techniques |
US5990506A (en) | 1996-03-20 | 1999-11-23 | California Institute Of Technology | Active pixel sensors with substantially planarized color filtering elements |
DE59712460D1 (de) | 1996-11-18 | 2005-12-01 | Novartis Ag | Messvorrichtung mit einem planaren optischen wellenleiter |
CN1251609A (zh) | 1997-02-12 | 2000-04-26 | 尤金·Y·查恩 | 分析聚合物的方法和产品 |
IT1290553B1 (it) | 1997-02-27 | 1998-12-10 | Ist Nazionale Fisica Nucleare | Rivelatore dell'energia e della posizione di incidenza di radiazioni elettromagnetiche o di particelle ionizzanti a deriva controllata |
EP2208789B1 (en) | 1997-03-12 | 2015-07-22 | Applied Biosystems, LLC | DNA polymerases having improved labeled nucleotide incorporation properties |
US6327410B1 (en) | 1997-03-14 | 2001-12-04 | The Trustees Of Tufts College | Target analyte sensors utilizing Microspheres |
US6825921B1 (en) * | 1999-11-10 | 2004-11-30 | Molecular Devices Corporation | Multi-mode light detection system |
DE19748211A1 (de) | 1997-10-31 | 1999-05-06 | Zeiss Carl Fa | Optisches Array-System und Reader für Mikrotiterplatten |
EP0921196A1 (en) | 1997-12-02 | 1999-06-09 | Roche Diagnostics GmbH | Modified DNA-polymerase from carboxydothermus hydrogenoformans and its use for coupled reverse transcription and polymerase chain reaction |
DE19810879A1 (de) | 1998-03-13 | 1999-09-16 | Roche Diagnostics Gmbh | Polymerasenchimären |
AU3199699A (en) | 1998-03-23 | 1999-10-18 | Invitrogen Corporation | Modified nucleotides and methods useful for nucleic acid sequencing |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
WO1999057321A1 (en) | 1998-05-01 | 1999-11-11 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and dna molecules |
GB9810350D0 (en) | 1998-05-14 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
US6716394B2 (en) | 1998-08-11 | 2004-04-06 | Caliper Technologies Corp. | DNA sequencing using multiple fluorescent labels being distinguishable by their decay times |
US6210896B1 (en) | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
US6280939B1 (en) | 1998-09-01 | 2001-08-28 | Veeco Instruments, Inc. | Method and apparatus for DNA sequencing using a local sensitive force detector |
JP4326050B2 (ja) | 1998-09-22 | 2009-09-02 | ハイスペック合資会社 | 高速撮像素子 |
WO2000036151A1 (en) | 1998-12-14 | 2000-06-22 | Li-Cor, Inc. | A heterogeneous assay for pyrophosphate detection |
US6445491B2 (en) | 1999-01-29 | 2002-09-03 | Irma America, Inc. | Method and apparatus for optical sectioning and imaging using time-gated parametric image amplification |
US7270951B1 (en) | 1999-03-10 | 2007-09-18 | Asm Scientific, Inc. | Method for direct nucleic acid sequencing |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
EP1681357A3 (en) | 1999-05-19 | 2006-07-26 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US6137117A (en) | 1999-06-21 | 2000-10-24 | The United States Of America As Represented By The Secretary Of The Navy | Integrating multi-waveguide sensor |
CN2433618Y (zh) * | 1999-10-29 | 2001-06-06 | 中国科学院上海原子核研究所 | 基因芯片检测装置 |
US6399335B1 (en) | 1999-11-16 | 2002-06-04 | Advanced Research And Technology Institute, Inc. | γ-phosphoester nucleoside triphosphates |
JP4433347B2 (ja) * | 2000-01-17 | 2010-03-17 | 富士フイルム株式会社 | 蛍光撮像装置 |
EP1285290A1 (en) | 2000-04-28 | 2003-02-26 | Edgelight Biosciences, Inc. | Micro-array evanescent wave fluorescence detection device |
US6917726B2 (en) | 2001-09-27 | 2005-07-12 | Cornell Research Foundation, Inc. | Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes |
AU2001268291A1 (en) | 2000-06-07 | 2001-12-17 | Li-Cor, Inc. | Charge-switch nucleotides |
US6936702B2 (en) | 2000-06-07 | 2005-08-30 | Li-Cor, Inc. | Charge-switch nucleotides |
US6975898B2 (en) | 2000-06-19 | 2005-12-13 | University Of Washington | Medical imaging, diagnosis, and therapy using a scanning single optical fiber system |
US7158224B2 (en) | 2000-06-25 | 2007-01-02 | Affymetrix, Inc. | Optically active substrates |
FR2813121A1 (fr) | 2000-08-21 | 2002-02-22 | Claude Weisbuch | Dispositif perfectionne de support d'elements chromophores |
AU2001286963A1 (en) | 2000-08-30 | 2002-03-13 | University Of Rochester | Method of performing reverse transcription reaction using reverse transcriptase encoded by non-ltr retrotransposable element |
AU2001284681A1 (en) | 2000-09-11 | 2002-03-26 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Fluidics system |
EP1207387A1 (en) | 2000-11-20 | 2002-05-22 | Institut Curie | Multi-photon imaging installation. |
JP4270742B2 (ja) | 2000-11-30 | 2009-06-03 | Necエレクトロニクス株式会社 | 固体撮像装置 |
WO2002086088A2 (en) | 2001-04-24 | 2002-10-31 | Li-Cor, Inc. | Polymerases with charge-switch activity and methods of generating such polymerases |
US7668697B2 (en) | 2006-02-06 | 2010-02-23 | Andrei Volkov | Method for analyzing dynamic detectable events at the single molecule level |
US7727722B2 (en) | 2001-08-29 | 2010-06-01 | General Electric Company | Ligation amplification |
US7041812B2 (en) | 2001-08-29 | 2006-05-09 | Amersham Biosciences Corp | Labeled nucleoside polyphosphates |
US7052839B2 (en) | 2001-08-29 | 2006-05-30 | Amersham Biosciences Corp | Terminal-phosphate-labeled nucleotides and methods of use |
US7244566B2 (en) | 2001-08-29 | 2007-07-17 | Ge Healthcare Bio-Sciences Corp. | Analyte detection |
US7223541B2 (en) | 2001-08-29 | 2007-05-29 | Ge Healthcare Bio-Sciences Corp. | Terminal-phosphate-labeled nucleotides and methods of use |
US7033762B2 (en) | 2001-08-29 | 2006-04-25 | Amersham Biosciences Corp | Single nucleotide amplification and detection by polymerase |
US7256019B2 (en) | 2001-08-29 | 2007-08-14 | Ge Healthcare Bio-Sciences Corp. | Terminal phosphate blocked nucleoside polyphosphates |
EP1436385A4 (en) | 2001-09-14 | 2005-12-14 | Invitrogen Corp | DNA POLYMERASES AND MUTANTS CORRESPONDING |
US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
GB2382648B (en) | 2001-12-11 | 2003-11-12 | Amersham Pharm Biotech Uk Ltd | System and method for time correlated multi-photon counting measurements |
CN1138862C (zh) * | 2002-01-28 | 2004-02-18 | 国前 | 一种核酸分析用收集装置及其应用方法 |
US7179654B2 (en) | 2002-03-18 | 2007-02-20 | Agilent Technologies, Inc. | Biochemical assay with programmable array detection |
US6924887B2 (en) * | 2002-03-27 | 2005-08-02 | Sarnoff Corporation | Method and apparatus for generating charge from a light pulse |
US8238993B2 (en) | 2002-04-04 | 2012-08-07 | Veralight, Inc. | Determination of a measure of a glycation end-product or disease state using tissue fluorescence lifetime |
US20040144927A1 (en) * | 2003-01-28 | 2004-07-29 | Auner Gregory W. | Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays |
US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
US20040106163A1 (en) | 2002-11-12 | 2004-06-03 | Workman Jerome James | Non-invasive measurement of analytes |
AU2003294365A1 (en) | 2002-11-19 | 2004-06-15 | Safetzone Technologies Corporation | Guest communication system and method |
JP4896708B2 (ja) | 2003-02-05 | 2012-03-14 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 新規リンカー類を有する末端リン酸標識ヌクレオチド類 |
US7745116B2 (en) | 2003-04-08 | 2010-06-29 | Pacific Biosciences Of California, Inc. | Composition and method for nucleic acid sequencing |
US7078670B2 (en) * | 2003-09-15 | 2006-07-18 | Imagerlabs, Inc. | Low noise charge gain circuit and CCD using same |
WO2005073407A1 (en) | 2003-10-07 | 2005-08-11 | Ut-Battelle, Llc | Advanced integrated circuit biochip |
SG147471A1 (en) | 2003-10-18 | 2008-11-28 | Bayer Healthcare Ag | Direct observation of molecular modifications in biological test systems by measuring fluorescence lifetime |
DE10348949A1 (de) * | 2003-10-18 | 2005-05-19 | Bayer Healthcare Ag | Direkte Beobachtung molekularer Veränderungen ind biologischen Testsystemen mittels Messungen der Fluoreszenz-Lebensdauer |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
US20070281288A1 (en) | 2004-01-27 | 2007-12-06 | Shimshon Belkin | Method and System for Detecting Analytes |
ATE463584T1 (de) | 2004-02-19 | 2010-04-15 | Helicos Biosciences Corp | Verfahren zur analyse von polynukleotidsequenzen |
EP1583150A1 (en) | 2004-03-31 | 2005-10-05 | CSEM Centre Suisse d'Electronique et de Microtechnique SA | Image sensor with large-area, high-sensitivity and high-speed pixels |
US20060019265A1 (en) | 2004-04-30 | 2006-01-26 | Kimberly-Clark Worldwide, Inc. | Transmission-based luminescent detection systems |
US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
EP1622200A1 (en) | 2004-07-26 | 2006-02-01 | CSEM Centre Suisse d'Electronique et de Microtechnique SA | Solid-state photodetector pixel and photodetecting method |
JP2008513782A (ja) | 2004-09-17 | 2008-05-01 | パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド | 分子解析のための装置及び方法 |
US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
US7345764B2 (en) | 2005-02-07 | 2008-03-18 | Vladimir Bulovic | Apparatus and method for a slim format spectrometer |
US20060223067A1 (en) | 2005-03-31 | 2006-10-05 | Paolo Vatta | Mutant DNA polymerases and methods of use |
US7365299B2 (en) | 2005-05-09 | 2008-04-29 | Sensors Unlimited, Inc. | Method and apparatus for providing flexible photodetector binning |
US7738086B2 (en) | 2005-05-09 | 2010-06-15 | The Trustees Of Columbia University In The City Of New York | Active CMOS biosensor chip for fluorescent-based detection |
JP2008546424A (ja) | 2005-06-28 | 2008-12-25 | アジェンコート パーソナル ジェノミクス コーポレイション | 修飾ポリヌクレオチドを作製する方法および配列決定する方法 |
US9017992B2 (en) | 2005-07-01 | 2015-04-28 | Dako Denmark A/S | In situ hybridization detection method |
US7426322B2 (en) | 2005-07-20 | 2008-09-16 | Searete Llc. | Plasmon photocatalysis |
US7405281B2 (en) | 2005-09-29 | 2008-07-29 | Pacific Biosciences Of California, Inc. | Fluorescent nucleotide analogs and uses therefor |
US7871777B2 (en) | 2005-12-12 | 2011-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | Probe for nucleic acid sequencing and methods of use |
EP1963536B1 (en) | 2005-12-22 | 2016-05-04 | Pacific Biosciences of California, Inc. | Polymerases for nucleotide analogue incorporation |
AU2006331512B2 (en) | 2005-12-22 | 2012-02-23 | Pacific Biosciences Of California, Inc. | Active surface coupled polymerases |
US7692783B2 (en) | 2006-02-13 | 2010-04-06 | Pacific Biosciences Of California | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US7715001B2 (en) | 2006-02-13 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US7995202B2 (en) | 2006-02-13 | 2011-08-09 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US20080050747A1 (en) | 2006-03-30 | 2008-02-28 | Pacific Biosciences Of California, Inc. | Articles having localized molecules disposed thereon and methods of producing and using same |
US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
JP5110535B2 (ja) | 2006-03-31 | 2012-12-26 | 国立大学法人静岡大学 | 半導体測距素子及び固体撮像装置 |
DE102006030541B4 (de) | 2006-06-23 | 2010-05-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Optische Anordnung |
US8207509B2 (en) | 2006-09-01 | 2012-06-26 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
EP2064488B1 (en) | 2006-09-01 | 2021-10-06 | Pacific Biosciences of California, Inc. | Device and method for analyzing materials |
US8471230B2 (en) | 2006-09-01 | 2013-06-25 | Pacific Biosciences Of California, Inc. | Waveguide substrates and optical systems and methods of use thereof |
AU2007309504B2 (en) | 2006-10-23 | 2012-09-13 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
FR2908888B1 (fr) | 2006-11-21 | 2012-08-03 | Centre Nat Rech Scient | Dispositif pour la detection exaltee de l'emission d'une particule cible |
JP5270835B2 (ja) | 2006-12-29 | 2013-08-21 | パナソニック株式会社 | 光検出素子、空間情報の検出装置 |
EP2132556B1 (en) | 2007-03-22 | 2011-05-11 | Universite De Strasbourg (Etablissement Public à Caractère Scientifique, Culturel et Professionel) | Device for sorting and concentrating electromagnetic energy and apparatus comprising at least one such device |
US20080241866A1 (en) | 2007-03-30 | 2008-10-02 | Pacific Biosciences Of California, Inc. | Systems and methods for enhancing fluorescent signals |
US7873085B2 (en) | 2007-10-23 | 2011-01-18 | Andrei Babushkin | Method and device for controlling optical output of laser diode |
WO2009082706A1 (en) | 2007-12-21 | 2009-07-02 | The Trustees Of Columbia University In The City Of New York | Active cmos sensor array for electrochemical biomolecular detection |
WO2009091847A2 (en) | 2008-01-14 | 2009-07-23 | Life Technologies Corporation | Compositions, methods and systems for single molecule sequencing |
CA2714630A1 (en) | 2008-02-07 | 2009-08-13 | Pacific Biosciences Of California, Inc. | Cis reactive oxygen quenchers integrated into linkers |
CA2715385A1 (en) | 2008-02-12 | 2009-08-20 | Pacific Biosciences Of California, Inc. | Compositions and methods for use in analytical reactions |
US8652781B2 (en) | 2008-02-12 | 2014-02-18 | Pacific Biosciences Of California, Inc. | Cognate sampling kinetics |
AU2009223702B2 (en) | 2008-03-13 | 2013-08-22 | Pacific Biosciences Of California, Inc. | Labeled reactants and their uses |
US7973146B2 (en) | 2008-03-26 | 2011-07-05 | Pacific Biosciences Of California, Inc. | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing |
EP3269824A1 (en) | 2008-03-28 | 2018-01-17 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
US8236499B2 (en) | 2008-03-28 | 2012-08-07 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
US8420366B2 (en) | 2008-03-31 | 2013-04-16 | Pacific Biosciences Of California, Inc. | Generation of modified polymerases for improved accuracy in single molecule sequencing |
US8906831B2 (en) | 2008-03-31 | 2014-12-09 | Pacific Biosciences Of California, Inc. | Single molecule loading methods and compositions |
WO2009145828A2 (en) | 2008-03-31 | 2009-12-03 | Pacific Biosciences Of California, Inc. | Two slow-step polymerase enzyme systems and methods |
US9127259B2 (en) | 2008-03-31 | 2015-09-08 | Pacific Biosciences Of California, Inc. | Enzymes resistant to photodamage |
US8999676B2 (en) | 2008-03-31 | 2015-04-07 | Pacific Biosciences Of California, Inc. | Recombinant polymerases for improved single molecule sequencing |
ES2614078T3 (es) | 2008-03-31 | 2017-05-29 | Pacific Biosciences Of California, Inc. | Generación de polimerasas modificadas para precisión mejorada en secuenciación de una única molécula |
CN102150037B (zh) * | 2008-07-11 | 2014-06-04 | 康奈尔大学 | 集成电荷传感器的纳米流体通道及基于该纳米流体通道的方法 |
JP5283216B2 (ja) * | 2008-07-31 | 2013-09-04 | 国立大学法人静岡大学 | 高速電荷転送フォトダイオード、ロックインピクセル及び固体撮像装置 |
WO2010025331A1 (en) * | 2008-08-28 | 2010-03-04 | Mesa Imaging Ag | Demodulation pixel with daisy chain charge storage sites and method of operation therefor |
EP2326733A2 (en) | 2008-09-05 | 2011-06-01 | Pacific Biosciences of California, Inc. | Engineering polymerases and reaction conditions for modified incorporation properties |
US8481264B2 (en) | 2008-09-19 | 2013-07-09 | Pacific Biosciences Of California, Inc. | Immobilized nucleic acid complexes for sequence analysis |
US8921046B2 (en) | 2008-09-19 | 2014-12-30 | Pacific Biosciences Of California, Inc. | Nucleic acid sequence analysis |
US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
WO2010036287A1 (en) | 2008-09-24 | 2010-04-01 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
US8383369B2 (en) | 2008-09-24 | 2013-02-26 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
AU2009300369B2 (en) | 2008-09-30 | 2014-08-14 | Pacific Biosciences Of California, Inc. | Ultra-high multiplex analytical systems and methods |
EP2182523B1 (en) * | 2008-10-31 | 2013-01-09 | CSEM Centre Suisse d'Electronique et de Microtechnique SA -Recherche et Développement | Charge sampling device and method based on a MOS-transmission line |
WO2010057185A1 (en) | 2008-11-17 | 2010-05-20 | Pacific Biosciences Of California, Inc. | Phospholink nucleotides for sequencing applications |
WO2010073136A2 (en) | 2008-12-22 | 2010-07-01 | Koninklijke Philips Electronics N.V. | High dynamic range light sensor |
WO2010074252A1 (ja) * | 2008-12-25 | 2010-07-01 | 国立大学法人静岡大学 | 半導体素子及び固体撮像装置 |
EP2391639A1 (en) | 2009-01-30 | 2011-12-07 | Oxford Nanopore Technologies Limited | Enzyme mutant |
BRPI0924456A2 (pt) | 2009-03-12 | 2016-02-16 | Rsp Systems As | sonda óptica para medir sinais de luz, e, método para coletar sinais ópticos de uma amostra. |
WO2010111674A2 (en) | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Methods and apparatus for single molecule sequencing using energy transfer detection |
WO2010117420A2 (en) | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
JP5415805B2 (ja) | 2009-03-31 | 2014-02-12 | オリンパスメディカルシステムズ株式会社 | 診断支援装置 |
EP2419716B1 (en) * | 2009-04-15 | 2012-08-22 | Koninklijke Philips Electronics N.V. | Device for time controlled fluorescence detection |
US20120224053A1 (en) | 2009-06-17 | 2012-09-06 | Board Of Regents, The University Of Texas System | Method and apparatus for quantitative microimaging |
US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
EP2284897B1 (en) * | 2009-08-14 | 2021-06-30 | Heptagon Micro Optics Pte. Ltd. | Demodulation pixel incorporating majority carrier current, buried channel and high-low junction |
WO2011040971A2 (en) | 2009-09-30 | 2011-04-07 | Pacific Biosciences Of California, Inc. | Generation of modified polymerases for improved accuracy in single molecule sequencing |
US9231006B2 (en) | 2009-10-05 | 2016-01-05 | National University Corporation Shizuoka University | Semiconductor element and solid-state imaging device |
US8278728B2 (en) | 2009-10-17 | 2012-10-02 | Florida Institute Of Technology | Array of concentric CMOS photodiodes for detection and de-multiplexing of spatially modulated optical channels |
WO2011068569A1 (en) | 2009-12-04 | 2011-06-09 | Biotium, Inc. | Heterocycle-substituted xanthene dyes |
JP6017107B2 (ja) | 2009-12-28 | 2016-10-26 | ソニー株式会社 | イメージセンサ及びその製造方法、並びにセンサデバイス |
WO2011090745A1 (en) | 2009-12-29 | 2011-07-28 | Life Technologies Corporation | Single molecule detection and sequencing using fluorescence lifetime imaging |
EP2362207A1 (de) | 2010-01-28 | 2011-08-31 | F. Hoffmann-La Roche AG | Messsystem und Messverfahren insbesondere zur Blutzuckerbestimmung |
CA2789932A1 (en) | 2010-02-19 | 2011-08-25 | Glysure Ltd | Intravascular glucose sensor |
WO2011103497A1 (en) | 2010-02-19 | 2011-08-25 | Pacific Biosciences Of California, Inc. | Illumination of integrated analytical systems |
US8994946B2 (en) | 2010-02-19 | 2015-03-31 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
WO2011119343A1 (en) | 2010-03-25 | 2011-09-29 | Mocon, Inc | Luminescence lifetime based analyte sensing instruments and calibration technique |
WO2011150431A1 (en) | 2010-05-28 | 2011-12-01 | The Regents Of The University Of Colorado, A Body Corporate | Multi-photon tissue imaging |
US8865077B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
US8865078B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
JP2012132741A (ja) | 2010-12-21 | 2012-07-12 | Fujifilm Corp | 時間分解蛍光測定装置、及び方法 |
US8946845B1 (en) | 2011-02-02 | 2015-02-03 | Aptina Imaging Corporation | Stacked pixels for high resolution CMOS image sensors with BCMD charge detectors |
WO2012129242A2 (en) | 2011-03-23 | 2012-09-27 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
WO2013040058A1 (en) | 2011-09-12 | 2013-03-21 | Jian Guo | Imaging fluorescence or luminescence lifetime |
US20130090537A1 (en) | 2011-10-07 | 2013-04-11 | 2M Engineering Limited | Blood glucose sensor |
CA2856163C (en) | 2011-10-28 | 2019-05-07 | Illumina, Inc. | Microarray fabrication system and method |
WO2013066959A1 (en) | 2011-10-31 | 2013-05-10 | The Trustees Of Columbia University In The City Of New York | Systems and methods for imaging using single photon avalanche diodes |
US9606060B2 (en) * | 2012-01-13 | 2017-03-28 | California Institute Of Technology | Filterless time-domain detection of one or more fluorophores |
US8906660B2 (en) | 2012-02-01 | 2014-12-09 | Pacific Biosciences Of California, Inc. | Recombinant polymerases with increased phototolerance |
EP3222627B1 (en) | 2012-02-15 | 2019-08-07 | Pacific Biosciences of California, Inc. | Polymerase enzyme substrates with protein shield |
DE102012206089B4 (de) | 2012-03-15 | 2017-02-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Halbleiterstruktur, verfahren zum betreiben derselben und herstellungsverfahren |
CN102914525B (zh) | 2012-04-10 | 2016-06-01 | 广东工业大学 | 基于光学加法外差调制的新型荧光寿命显微成像装置及方法 |
WO2013171197A1 (en) | 2012-05-15 | 2013-11-21 | Ait Austrian Institute Of Technology Gmbh | Compact plasmon-enhanced fluorescence biosensor |
US9372308B1 (en) | 2012-06-17 | 2016-06-21 | Pacific Biosciences Of California, Inc. | Arrays of integrated analytical devices and methods for production |
CA3178340A1 (en) * | 2012-08-20 | 2014-02-27 | Illumina, Inc. | Method and system for fluorescence lifetime based sequencing |
JP6281771B2 (ja) | 2012-10-30 | 2018-02-21 | パナソニックIpマネジメント株式会社 | 蛍光検出装置 |
NL2011568A (en) | 2012-10-31 | 2014-05-06 | Asml Netherlands Bv | Sensor and lithographic apparatus. |
WO2014099776A1 (en) | 2012-12-18 | 2014-06-26 | Pacific Biosciences Of California, Inc. | Illumination of optical analytical devices |
GB201302664D0 (en) | 2013-02-15 | 2013-04-03 | Cmosis Nv | A pixel structure |
CA2902319A1 (en) | 2013-02-28 | 2014-09-04 | Olive Medical Corporation | Videostroboscopy of vocal chords with cmos sensors |
US9741754B2 (en) | 2013-03-06 | 2017-08-22 | Apple Inc. | Charge transfer circuit with storage nodes in image sensors |
KR102007277B1 (ko) | 2013-03-11 | 2019-08-05 | 삼성전자주식회사 | 3차원 이미지 센서의 거리 픽셀 및 이를 포함하는 3차원 이미지 센서 |
US9260251B2 (en) | 2013-07-09 | 2016-02-16 | Nd Industries, Inc. | Multi-row magnetic dial for the conveyance of workpieces and related method |
US20150042954A1 (en) | 2013-08-08 | 2015-02-12 | University Of Rochester | System and Method for Fluorescence Lifetime Imaging Aided by Adaptive Optics |
CA2930836A1 (en) | 2013-11-17 | 2015-05-21 | Quantum-Si Incorporated | Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens |
CN103728446B (zh) * | 2013-12-11 | 2016-02-24 | 天津大学 | 光子计数型多通道时间分辨荧光免疫分析***及计数方法 |
US9736388B2 (en) | 2013-12-13 | 2017-08-15 | Bio-Rad Laboratories, Inc. | Non-destructive read operations with dynamically growing images |
EP3099232B1 (en) | 2014-01-31 | 2021-08-18 | The General Hospital Corporation | System and method for photoluminescence detection |
US9765395B2 (en) | 2014-04-28 | 2017-09-19 | Nanomedical Diagnostics, Inc. | System and method for DNA sequencing and blood chemistry analysis |
KR20150134543A (ko) | 2014-05-22 | 2015-12-02 | 삼성전자주식회사 | 소자 제조용 기판 및 반도체 소자 |
EP3957232A1 (en) | 2014-07-24 | 2022-02-23 | University Health Network | Collection and analysis of data for diagnostic purposes |
US9759658B2 (en) | 2014-08-08 | 2017-09-12 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
WO2016023010A1 (en) | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting, and analyzing molecules |
MX2017001808A (es) | 2014-08-08 | 2018-02-08 | Quantum Si Inc | Dispositivo integrado con fuente de luz externa para el sondeo, deteccion y analisis de moleculas. |
EP3235000B1 (en) | 2014-12-19 | 2021-01-13 | G-ray Switzerland SA | Method for manufacturing a monolithic cmos integrated pixel detector |
US9871065B2 (en) | 2014-12-22 | 2018-01-16 | Google Inc. | RGBZ pixel unit cell with first and second Z transfer gates |
US9666748B2 (en) | 2015-01-14 | 2017-05-30 | International Business Machines Corporation | Integrated on chip detector and zero waveguide module structure for use in DNA sequencing |
KR101828760B1 (ko) | 2015-02-09 | 2018-02-12 | 에스프로스 포토닉스 아게 | Tof 거리 센서 |
US10487356B2 (en) | 2015-03-16 | 2019-11-26 | Pacific Biosciences Of California, Inc. | Integrated devices and systems for free-space optical coupling |
TWI569008B (zh) | 2015-04-27 | 2017-02-01 | 財團法人工業技術研究院 | 尿素濃度檢測元件以及尿素濃度檢測方法 |
US10174363B2 (en) | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
US10246742B2 (en) | 2015-05-20 | 2019-04-02 | Quantum-Si Incorporated | Pulsed laser and bioanalytic system |
MX2017014821A (es) | 2015-05-20 | 2018-06-27 | Quantum Si Inc | Método para determinar la secuencia de un acido nucleico usando luminiscencia resuelta por tiempo. |
US10976257B2 (en) | 2015-06-08 | 2021-04-13 | The Regents Of The University Of Michigan | Pixel circuit and method for optical sensing |
CN105300949B (zh) | 2015-11-26 | 2019-06-11 | 浙江大学 | 一种荧光寿命测量方法及装置 |
CA3012705A1 (en) | 2016-02-17 | 2017-08-24 | Tesseract Health, Inc. | Sensor and device for lifetime imaging and detection applications |
CN109313925B (zh) | 2016-06-01 | 2022-09-02 | 宽腾矽公司 | 脉冲命名器及基质命名器 |
US10249656B2 (en) | 2016-06-07 | 2019-04-02 | Semiconductor Components Industries, Llc | Charge packet signal processing using pinned photodiode devices |
CN110168732B (zh) | 2016-12-22 | 2024-03-08 | 宽腾矽公司 | 具有直接合并像素的整合式光电侦测器 |
AU2019288394A1 (en) | 2018-06-22 | 2021-01-07 | Quantum-Si Incorporated | Integrated photodetector with charge storage bin of varied detection time |
BR112021003146A2 (pt) | 2018-08-29 | 2021-05-11 | Quantum-Si Incorporated | sistema e métodos para detectar o tempo de vida ao usar fotodetectores de contagem de fótons |
-
2015
- 2015-08-07 US US14/821,656 patent/US9759658B2/en active Active
- 2015-08-07 WO PCT/US2015/044360 patent/WO2016022998A2/en active Application Filing
- 2015-08-07 EP EP18202357.2A patent/EP3471402B1/en active Active
- 2015-08-07 CN CN202010528184.4A patent/CN111710687B/zh active Active
- 2015-08-07 KR KR1020227011326A patent/KR102452571B1/ko active IP Right Grant
- 2015-08-07 CA CA2957540A patent/CA2957540A1/en active Pending
- 2015-08-07 EP EP15759983.8A patent/EP3194935B1/en active Active
- 2015-08-07 CN CN201580054728.5A patent/CN107112333B/zh active Active
- 2015-08-07 BR BR112017002485-3A patent/BR112017002485B1/pt active IP Right Grant
- 2015-08-07 KR KR1020177006550A patent/KR102384909B1/ko active IP Right Grant
- 2015-08-07 MX MX2021007934A patent/MX2021007934A/es unknown
- 2015-08-07 AU AU2015300766A patent/AU2015300766B2/en active Active
- 2015-08-07 KR KR1020227034502A patent/KR102585730B1/ko active IP Right Grant
- 2015-08-07 JP JP2017506920A patent/JP6707520B2/ja active Active
- 2015-08-07 MX MX2017001806A patent/MX2017001806A/es unknown
-
2016
- 2016-09-09 US US15/261,724 patent/US9696258B2/en active Active
- 2016-09-09 US US15/261,697 patent/US9606058B2/en active Active
-
2017
- 2017-07-21 US US15/656,139 patent/US9945779B2/en active Active
-
2018
- 2018-03-07 US US15/914,019 patent/US10775305B2/en active Active
-
2020
- 2020-05-20 JP JP2020088106A patent/JP6935541B2/ja active Active
- 2020-08-04 US US16/984,537 patent/US11209363B2/en active Active
-
2021
- 2021-04-30 AU AU2021202729A patent/AU2021202729B2/en active Active
- 2021-11-23 US US17/533,170 patent/US11719636B2/en active Active
-
2023
- 2023-06-13 US US18/333,952 patent/US20230408411A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2017001806A (es) | Dispositivo integrado para el depósito temporal de fotones recibidos. | |
MX2021014745A (es) | Fotodetector integrado con agrupamiento de pixeles directo. | |
EP3200241C0 (en) | SOLAR CELL MODULE | |
EP2987186A4 (en) | Integrated avalanche photodiode arrays | |
MX2020013788A (es) | Fotodetector integrado con deposito de almacenamiento de carga con tiempo de deteccion variado. | |
PT3047517T (pt) | Corte de um wafer semicondutor a partir do lado traseiro e lado dianteiro | |
PL3826075T3 (pl) | Moduł ogniw słonecznych | |
EP3460998C0 (en) | SOLAR CELL MODULE INCLUDING INTEGRATED INVERTER | |
PL3182466T3 (pl) | Hermetyzacja modułu fotowoltaicznego | |
SG11201601033SA (en) | Radial p-n junction nanowire solar cells | |
EP2743732A3 (en) | Photon-counting detector and readout circuit | |
EP3076439A4 (en) | WRAPPING FOIL FOR A SOLAR CELL MODULE | |
EP3089356A4 (en) | SOLAR CELL MODULE | |
HK1224081A1 (zh) | 利用寄生光電二極管的具有改進的動態范圍的成像陣列 | |
IL260188B (en) | Avalanche photodetectors | |
EP3202030A4 (en) | Hybrid trough solar power system using photovoltaic two-stage light concentration | |
HRP20171417B8 (hr) | Fotonaponska solarna ćelija | |
GB2530988B (en) | Monolithically integrated thin-film electronic conversion unit for lateral multifunction thin-film solar cells | |
EP3144981C0 (en) | SOLAR CELL MODULE | |
GB201307320D0 (en) | Charge mediators for sensitised solar cells | |
EP3161875A4 (en) | Through silicon via based photovoltaic cell | |
EP2944739A4 (en) | HOLDING DEVICE FOR SOLAR CELL MODULE | |
PL3370264T3 (pl) | Moduł ogniwa słonecznego | |
EP3631974C0 (en) | SOLAR CELL MODULE | |
TWM490116U (en) | Solar cell module |