MX2021007870A - Anticuerpos monoclonales especificos para la proteina quimerica l del virus de la parainfluenza humana (piv), secuencias nucleotidicas; metodo y kit de diagnostico de infeccion producida por piv. - Google Patents

Anticuerpos monoclonales especificos para la proteina quimerica l del virus de la parainfluenza humana (piv), secuencias nucleotidicas; metodo y kit de diagnostico de infeccion producida por piv.

Info

Publication number
MX2021007870A
MX2021007870A MX2021007870A MX2021007870A MX2021007870A MX 2021007870 A MX2021007870 A MX 2021007870A MX 2021007870 A MX2021007870 A MX 2021007870A MX 2021007870 A MX2021007870 A MX 2021007870A MX 2021007870 A MX2021007870 A MX 2021007870A
Authority
MX
Mexico
Prior art keywords
piv
protein
parainfluenza virus
binds
kit
Prior art date
Application number
MX2021007870A
Other languages
English (en)
Inventor
Parra Alexis Mikes Kalergis
Ramírez Susan Marcela Bueno
Original Assignee
Univ Pontificia Catolica Chile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pontificia Catolica Chile filed Critical Univ Pontificia Catolica Chile
Publication of MX2021007870A publication Critical patent/MX2021007870A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/115—Paramyxoviridae, e.g. parainfluenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La invención presenta la generación de anticuerpos monoclonales, o fragmentos de los mismos, que reconocen la proteína L quimérica del virus parainfluenza humano (PIV), donde dichos anticuerpos monoclonales o fragmentos de estos comprenden una región variable de la cadena pesada y una región variable de la cadena liviana. Se proporciona además, un método de diagnóstico de infección por PIV en una muestra biológica de secreción nasofaríngea, que utiliza los anticuerpos monoclonales en formato de kit de diagnóstico.
MX2021007870A 2018-12-28 2019-12-27 Anticuerpos monoclonales especificos para la proteina quimerica l del virus de la parainfluenza humana (piv), secuencias nucleotidicas; metodo y kit de diagnostico de infeccion producida por piv. MX2021007870A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CL2018003869A CL2018003869A1 (es) 2018-12-28 2018-12-28 Anticuerpos monoclonales específicos para la proteína quimérica l del virus de la parainfluenza humana (piv), secuencias nucleotídicas; método y kit de diagnóstico de infección producida por piv
PCT/CL2019/050157 WO2020132774A1 (es) 2018-12-28 2019-12-27 Anticuerpo monoclonal o una porción de unión a antígeno del mismo que se une a la proteína l del virus parainfluenza humano (piv); método y kit para detectar al virus piv

Publications (1)

Publication Number Publication Date
MX2021007870A true MX2021007870A (es) 2021-12-10

Family

ID=71125643

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021007870A MX2021007870A (es) 2018-12-28 2019-12-27 Anticuerpos monoclonales especificos para la proteina quimerica l del virus de la parainfluenza humana (piv), secuencias nucleotidicas; metodo y kit de diagnostico de infeccion producida por piv.

Country Status (14)

Country Link
US (1) US20220089697A1 (es)
EP (1) EP3904379A4 (es)
KR (1) KR20210110660A (es)
CN (1) CN113490685A (es)
AR (1) AR117548A1 (es)
BR (1) BR112021012788A2 (es)
CA (1) CA3125208A1 (es)
CL (1) CL2018003869A1 (es)
CO (1) CO2021008770A2 (es)
MX (1) MX2021007870A (es)
PE (1) PE20212104A1 (es)
UY (1) UY38534A (es)
WO (1) WO2020132774A1 (es)
ZA (1) ZA202104990B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113736920B (zh) * 2021-09-15 2023-09-01 丹娜(天津)生物科技股份有限公司 一种九项呼吸道病原体分子检测试剂盒及其使用方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015664A (en) 1995-11-03 2000-01-18 Mcw Research Foundation Multiplex PCR assay using unequal primer concentrations to detect HPIV 1,2,3 and RSV A,B and influenza virus A, B
US20100233674A1 (en) * 2002-04-25 2010-09-16 University Hospitals Of Cleveland Cells for detection and production of influenza and parainfluenza viruses
TW200501985A (en) * 2002-07-25 2005-01-16 Medimmune Inc Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies
US8492097B2 (en) * 2006-04-24 2013-07-23 Diagnostic Hybrids, Inc. Compositions and methods for human metapneumovirus monoclonal antibodies
US8003314B2 (en) * 2007-04-16 2011-08-23 Diagnostic Hybrids, Inc. Methods for direct fluorescent antibody virus detection in liquids
WO2011020079A1 (en) * 2009-08-13 2011-02-17 Calmune Corporation Antibodies against human respiratory syncytial virus (rsv) and methods of use
CA3062786C (en) * 2010-07-09 2022-04-19 Janssen Vaccines & Prevention B.V. Anti-human respiratory syncytial virus (rsv) antibodies and methods of use
CN102140550A (zh) 2011-03-25 2011-08-03 武汉大学 副流感病毒一步rt-pcr检测试剂盒
CA3128591A1 (en) * 2012-01-24 2013-08-01 University Of Georgia Research Foundation, Inc. Parainfluenza virus 5 based vaccines
CL2015002152A1 (es) * 2015-07-31 2016-06-03 Pontificia Universidad Católica De Chile Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh
CN105441589B (zh) 2015-12-21 2018-12-21 深圳生科原生物股份有限公司 人副流感病毒ⅰ、ⅱ、ⅲ、ⅳ型四重pcr检测试剂盒及其检测方法
CL2016000164A1 (es) * 2016-01-21 2016-07-29 Pontificia Universidad Católica De Chile Anticuerpos monoclonales específicos para el antígeno piii de adenovirus humano (adv), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnóstico de la infección causada por adv.

Also Published As

Publication number Publication date
AR117548A1 (es) 2021-08-11
CN113490685A (zh) 2021-10-08
CO2021008770A2 (es) 2021-07-19
CL2018003869A1 (es) 2021-01-15
EP3904379A1 (en) 2021-11-03
CA3125208A1 (en) 2020-07-02
WO2020132774A1 (es) 2020-07-02
US20220089697A1 (en) 2022-03-24
BR112021012788A2 (pt) 2021-11-16
UY38534A (es) 2020-07-31
KR20210110660A (ko) 2021-09-08
EP3904379A4 (en) 2022-08-17
PE20212104A1 (es) 2021-11-04
ZA202104990B (en) 2023-01-25

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