MX2021006635A - Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas. - Google Patents

Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas.

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Publication number
MX2021006635A
MX2021006635A MX2021006635A MX2021006635A MX2021006635A MX 2021006635 A MX2021006635 A MX 2021006635A MX 2021006635 A MX2021006635 A MX 2021006635A MX 2021006635 A MX2021006635 A MX 2021006635A MX 2021006635 A MX2021006635 A MX 2021006635A
Authority
MX
Mexico
Prior art keywords
hbv
methods
hepatitis
virus
irna compositions
Prior art date
Application number
MX2021006635A
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English (en)
Inventor
Stuart Milstein
Martin Maier
Vasant Jadhav
Laura Sepp-Lorenzino
Gregory Hinkle
Muthiah Manoharan
Kallanthottathil G Rajeev
Original Assignee
Alnylam Pharmaceuticals Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54542627&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2021006635(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2021006635A publication Critical patent/MX2021006635A/es

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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
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    • C12N2310/33—Chemical structure of the base
    • C12N2310/335—Modified T or U
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

Abstract

La presente invención se refiere a agentes de iARN, por ejemplo, agentes de iARN bicatenarios, que actúan sobre el genoma del virus de la hepatitis B (5 HBV) y métodos para utilizar tales agentes de iARN con el fin de inhibir la expresión de uno o más genes del HBV y métodos para tratar a sujetos que padecen una infección por el HBV y/o un trastorno asociado con el HBV, por ejemplo, una infección crónica de tipo hepatitis B.
MX2021006635A 2014-11-10 2017-05-08 Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas. MX2021006635A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077672P 2014-11-10 2014-11-10
US201462077799P 2014-11-10 2014-11-10
US201562137464P 2015-03-24 2015-03-24

Publications (1)

Publication Number Publication Date
MX2021006635A true MX2021006635A (es) 2021-07-07

Family

ID=54542627

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017005958A MX2017005958A (es) 2014-11-10 2015-11-10 Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas.
MX2021006635A MX2021006635A (es) 2014-11-10 2017-05-08 Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017005958A MX2017005958A (es) 2014-11-10 2015-11-10 Composiciones de acido ribonucleico de interferencia (arni) contra el virus de la hepatitis b (hbv) y metodos de uso de estas.

Country Status (23)

Country Link
US (4) US10640770B2 (es)
EP (3) EP3647424A1 (es)
JP (5) JP2017534290A (es)
KR (3) KR20170077251A (es)
CN (4) CN113699151B (es)
AU (3) AU2015346513A1 (es)
BR (2) BR122021001218B1 (es)
CA (2) CA3233743A1 (es)
CY (1) CY1122520T1 (es)
DK (1) DK3218489T3 (es)
ES (1) ES2761912T3 (es)
HK (1) HK1255502A1 (es)
HR (1) HRP20192177T1 (es)
HU (1) HUE047535T2 (es)
JO (2) JOP20200092A1 (es)
MA (2) MA40843A (es)
MX (2) MX2017005958A (es)
PL (1) PL3218489T3 (es)
PT (1) PT3218489T (es)
SG (3) SG10202007323VA (es)
SI (1) SI3218489T1 (es)
TW (3) TWI710633B (es)
WO (2) WO2016077321A1 (es)

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TW202237849A (zh) 2022-10-01
TW201628659A (zh) 2016-08-16
US20170349900A1 (en) 2017-12-07
CA3233743A1 (en) 2016-05-19
HRP20192177T1 (hr) 2020-02-21
TW202106878A (zh) 2021-02-16
BR112017008868A2 (pt) 2018-01-16
CN108064293A (zh) 2018-05-22
PT3218489T (pt) 2019-12-18
EP3647424A1 (en) 2020-05-06
WO2016077349A1 (en) 2016-05-19
BR112017008868B1 (pt) 2023-03-21
MA40851A (fr) 2017-09-20
CN108064294A (zh) 2018-05-22
CN113801882A (zh) 2021-12-17
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