MX2021006408A - Terapia de combinacion de radioinmunoconjugados con inhibidores de da?os y reparaciones del adn. - Google Patents
Terapia de combinacion de radioinmunoconjugados con inhibidores de da?os y reparaciones del adn.Info
- Publication number
- MX2021006408A MX2021006408A MX2021006408A MX2021006408A MX2021006408A MX 2021006408 A MX2021006408 A MX 2021006408A MX 2021006408 A MX2021006408 A MX 2021006408A MX 2021006408 A MX2021006408 A MX 2021006408A MX 2021006408 A MX2021006408 A MX 2021006408A
- Authority
- MX
- Mexico
- Prior art keywords
- radioimmunoconjugates
- dna damage
- combination therapy
- inhibitor combination
- repair inhibitor
- Prior art date
Links
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 229940051022 radioimmunoconjugate Drugs 0.000 title abstract 2
- 230000028617 response to DNA damage stimulus Effects 0.000 abstract 1
Classifications
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- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
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- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
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- A61K51/04—Organic compounds
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- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
- A61K51/1036—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against hormone receptors
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
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- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Terapias de combinación que comprenden la administración de radioinmunoconjugados e inhibidores de la respuesta al daño del ADN.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862774847P | 2018-12-03 | 2018-12-03 | |
PCT/IB2019/001292 WO2020115548A1 (en) | 2018-12-03 | 2019-12-03 | Radioimmunoconjugates and dna damage and repair inhibitor combination therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021006408A true MX2021006408A (es) | 2021-10-22 |
Family
ID=70973593
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021006408A MX2021006408A (es) | 2018-12-03 | 2019-12-03 | Terapia de combinacion de radioinmunoconjugados con inhibidores de da?os y reparaciones del adn. |
MX2021006407A MX2021006407A (es) | 2018-12-03 | 2019-12-03 | Terapia de combinacion de radioinmunoconjugados con inhibidor del punto de control. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021006407A MX2021006407A (es) | 2018-12-03 | 2019-12-03 | Terapia de combinacion de radioinmunoconjugados con inhibidor del punto de control. |
Country Status (18)
Country | Link |
---|---|
US (5) | US11446401B2 (es) |
EP (2) | EP3890790A4 (es) |
JP (2) | JP2022511471A (es) |
KR (2) | KR20210099073A (es) |
CN (3) | CN113474014A (es) |
AU (2) | AU2019393257A1 (es) |
BR (2) | BR112021010799A2 (es) |
CA (2) | CA3119917A1 (es) |
CL (2) | CL2021001433A1 (es) |
EA (2) | EA202191556A1 (es) |
IL (2) | IL283613A (es) |
MA (2) | MA54401A (es) |
MX (2) | MX2021006408A (es) |
PE (2) | PE20211286A1 (es) |
PH (2) | PH12021551237A1 (es) |
SG (2) | SG11202105112RA (es) |
WO (2) | WO2020115548A1 (es) |
ZA (1) | ZA202103429B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2022516170A (ja) * | 2019-01-04 | 2022-02-24 | アクティニウム ファーマシューティカルズ インコーポレイテッド | Parpインヒビターおよび抗体放射性物質結合体の組み合わせを使用してがんを処置するための方法 |
KR20220125330A (ko) * | 2020-01-10 | 2022-09-14 | 퓨전 파마슈티칼즈 인크. | 지속 면역요법 |
WO2021207086A1 (en) * | 2020-04-06 | 2021-10-14 | Fusion Pharmaceuticals Inc. | Tem-1-targeted radioimmunoconjugates and uses thereof |
WO2022169634A1 (en) * | 2021-02-02 | 2022-08-11 | Unm Rainforest Innovations | Combination therapy for the treatment of cancer |
US11541134B1 (en) | 2021-08-02 | 2023-01-03 | Rayzebio, Inc. | Stabilized compositions of radionuclides and uses thereof |
CA3233733A1 (en) * | 2021-09-29 | 2023-04-06 | National Research Council Of Canada | Egfrviii-targeted compounds and uses thereof |
WO2023081698A1 (en) * | 2021-11-02 | 2023-05-11 | Fusion Pharmaceuticals Inc. | Methods of treating cancer |
WO2023141717A1 (en) * | 2022-01-28 | 2023-08-03 | Fusion Pharmaceuticals Inc. | Ntsr1-targeted radiopharmaceuticals and dna damage response inhibitor combination therapy |
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US5053503A (en) * | 1989-02-17 | 1991-10-01 | Centocor | Chelating agents |
AU2238292A (en) | 1991-06-14 | 1993-01-12 | Xoma Corporation | Microbially-produced antibody fragments and their conjugates |
TR199902553T2 (xx) | 1997-04-14 | 2000-03-21 | Micromet Gesellschaft F�R Biomedizinische Forschung Mbh | �nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�. |
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EA200802061A1 (ru) * | 2006-03-28 | 2009-04-28 | Байоджен Айдек Эмэй Инк. | Антитело или его фрагмент, специфично связывающееся с рецептором 1 инсулиноподобного фактора роста (igf-r1) (варианты), композиция на его основе, полинуклеотид, кодирующий вариабельную область антитела (варианты), содержащие полинуклеотид композиция (варианты) и вектор, содержащая вектор клетка-хозяин (варианты), способ продуцирования антитела или его фрагмента (варианты) и способ лечения гиперпролиферативного заболевания у животного организма |
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