MX2021003819A - Modulators of alpha-1 antitrypsin. - Google Patents

Modulators of alpha-1 antitrypsin.

Info

Publication number
MX2021003819A
MX2021003819A MX2021003819A MX2021003819A MX2021003819A MX 2021003819 A MX2021003819 A MX 2021003819A MX 2021003819 A MX2021003819 A MX 2021003819A MX 2021003819 A MX2021003819 A MX 2021003819A MX 2021003819 A MX2021003819 A MX 2021003819A
Authority
MX
Mexico
Prior art keywords
alpha
antitrypsin
modulators
aatd
compositions
Prior art date
Application number
MX2021003819A
Other languages
Spanish (es)
Inventor
Adam Looker
Stefanie Roeper
Dennis James Hurley
Yi Shi
Peter Jones
Brad D Maxwell
Kevin Michael Cottrell
John Patrick Maxwell
Simon Giroux
Michael John Boyd
Michael Waldo
Mettachit Navamal
Michael Aaron Brodney
Ales Medek
Diane M Boucher
Cavan Mckeon Bligh
Mary Elizabeth Eccles
Kevin James Gagnon
Sarah Carol Hood
Joshua Kennedy Hussey
Setu Roday
Rupa Sawant
Qing Tang
Upul Keerthi Bandarage
Veronique Damagnez
Fanning Lev Tyler Dewey
Jr Robert Francis Fimognari
Barrantes Pedro M Garcia
Jr Ronald Lee Grey
Amy Beth Hall
Jr Mac Arthur Johnson
Sarathy Kesavan
Philippe Marcel Nuhant
Rebecca Jane Swett
Timothy Lewis Tapley
Stephen A Thomson
Jinwang Xu
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2021003819A publication Critical patent/MX2021003819A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).
MX2021003819A 2018-10-05 2019-10-04 Modulators of alpha-1 antitrypsin. MX2021003819A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862742148P 2018-10-05 2018-10-05
US201862768662P 2018-11-16 2018-11-16
PCT/US2019/054681 WO2020081257A1 (en) 2018-10-05 2019-10-04 Modulators of alpha-1 antitrypsin

Publications (1)

Publication Number Publication Date
MX2021003819A true MX2021003819A (en) 2021-06-23

Family

ID=69467663

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021003819A MX2021003819A (en) 2018-10-05 2019-10-04 Modulators of alpha-1 antitrypsin.

Country Status (16)

Country Link
US (2) US11623924B2 (en)
EP (1) EP3860712A1 (en)
JP (1) JP2022512588A (en)
KR (1) KR20210089656A (en)
CN (1) CN113164761A (en)
AU (1) AU2019362753A1 (en)
BR (1) BR112021006392A2 (en)
CA (1) CA3114672A1 (en)
CO (1) CO2021005884A2 (en)
IL (1) IL281884A (en)
JO (1) JOP20210060A1 (en)
MA (1) MA53827A (en)
MX (1) MX2021003819A (en)
TW (1) TW202024091A (en)
UY (1) UY38403A (en)
WO (1) WO2020081257A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11623924B2 (en) 2018-10-05 2023-04-11 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
UY38696A (en) * 2019-05-14 2020-11-30 Vertex Pharma ALPHA-1 ANTITRYPSIN MODULATORS
TW202116303A (en) * 2019-10-02 2021-05-01 美商維泰克斯製藥公司 Methods of treatment for alpha-1 antitrypsin deficiency
GB201918416D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency
GB201918413D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency
GB201918404D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of aplha1-antitrypsin deficiency
GB201918410D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of alpha1-antitrypsin deficiency
GB201918414D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency
AU2021247282A1 (en) * 2020-04-03 2022-10-27 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
GB202009074D0 (en) 2020-06-15 2020-07-29 Z Factor Ltd Compound
MX2023001084A (en) 2020-07-27 2023-05-15 Vertex Pharma Processes for preparing modulators of alpha-1 antitrypsin.
WO2022104353A1 (en) 2020-11-12 2022-05-19 Vertex Pharmaceuticals Incorporated Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat
KR20230110313A (en) * 2020-11-17 2023-07-21 버텍스 파마슈티칼스 인코포레이티드 Solid form of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid
GB202108523D0 (en) 2021-06-15 2021-07-28 Z Factor Ltd Compositions and their use for the treatment of alpha1-antitrypsin deficiency
CN114605385B (en) * 2022-03-25 2023-09-08 河南大学 Indole piperidine urea TRPV1 antagonism/FAAH inhibition double-target drug, preparation method and application

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TW202116303A (en) 2019-10-02 2021-05-01 美商維泰克斯製藥公司 Methods of treatment for alpha-1 antitrypsin deficiency
WO2021155087A1 (en) 2020-01-30 2021-08-05 Vertex Pharmaceuticals Incorporated Methods of treatment for alpha-1 antitrypsin deficiency
WO2021203023A1 (en) 2020-04-03 2021-10-07 Vertex Pharmaceuticals Incorporated Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)
AU2021247282A1 (en) 2020-04-03 2022-10-27 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
JP2023520397A (en) 2020-04-03 2023-05-17 バーテックス ファーマシューティカルズ インコーポレイテッド Modulator of alpha 1-antitrypsin
EP4126881A1 (en) 2020-04-03 2023-02-08 Vertex Pharmaceuticals Incorporated Pyrano[4,3-b]l ndole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)
CN115715292A (en) 2020-04-03 2023-02-24 弗特克斯药品有限公司 1H-pyrazolo [4,3-g ] isoquinoline and 1H-pyrazolo [4,3-g ] quinoline derivatives as alpha-1-antitrypsin modulators for the treatment of alpha-1-antitrypsin deficiency (AATD)
AU2021246104A1 (en) 2020-04-03 2022-10-20 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
MX2023001084A (en) 2020-07-27 2023-05-15 Vertex Pharma Processes for preparing modulators of alpha-1 antitrypsin.

Also Published As

Publication number Publication date
CN113164761A (en) 2021-07-23
JOP20210060A1 (en) 2023-01-30
KR20210089656A (en) 2021-07-16
WO2020081257A1 (en) 2020-04-23
CO2021005884A2 (en) 2021-05-20
TW202024091A (en) 2020-07-01
JP2022512588A (en) 2022-02-07
US20230265080A1 (en) 2023-08-24
US20210179587A1 (en) 2021-06-17
MA53827A (en) 2021-09-15
CA3114672A1 (en) 2020-04-23
IL281884A (en) 2021-05-31
US11623924B2 (en) 2023-04-11
AU2019362753A1 (en) 2021-05-20
UY38403A (en) 2020-04-30
BR112021006392A2 (en) 2021-07-06
EP3860712A1 (en) 2021-08-11

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