MX2020013373A - Compuestos de naftiridinona utiles como activadores de celulas t. - Google Patents

Compuestos de naftiridinona utiles como activadores de celulas t.

Info

Publication number
MX2020013373A
MX2020013373A MX2020013373A MX2020013373A MX2020013373A MX 2020013373 A MX2020013373 A MX 2020013373A MX 2020013373 A MX2020013373 A MX 2020013373A MX 2020013373 A MX2020013373 A MX 2020013373A MX 2020013373 A MX2020013373 A MX 2020013373A
Authority
MX
Mexico
Prior art keywords
sub
compounds
compounds useful
cell activators
naphthyridinone compounds
Prior art date
Application number
MX2020013373A
Other languages
English (en)
Inventor
Louis S Chupak
Robert G Gentles
Xiaofan Zheng
Scott W Martin
Min Ding
Ivar M Mcdonald
Richard E Olson
Stephen E Mercer
Upender Velaparthi
Yazhong Huang
Michael Wichroski
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2020013373A publication Critical patent/MX2020013373A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se describen compuestos de la fórmula (I): (ver Fórmula) o una sal de los mismos, en donde: R1, R2, R3 y R4 se definen aquí. También se describen métodos para usar tales compuestos para inhibir la actividad de una o ambos de diacilglicerol cinasa alfa (DGKa) y diacilglicerol cinasa zeta (DGK?), y composiciones farmacéuticas que comprenden tales compuestos. Estos compuestos son útiles en el tratamiento de infecciones virales y trastornos proliferativos, como el cáncer.
MX2020013373A 2018-06-27 2019-06-26 Compuestos de naftiridinona utiles como activadores de celulas t. MX2020013373A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862690444P 2018-06-27 2018-06-27
PCT/US2019/039131 WO2020006016A1 (en) 2018-06-27 2019-06-26 Naphthyridinone compounds useful as t cell activators

Publications (1)

Publication Number Publication Date
MX2020013373A true MX2020013373A (es) 2021-03-09

Family

ID=67297314

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020013373A MX2020013373A (es) 2018-06-27 2019-06-26 Compuestos de naftiridinona utiles como activadores de celulas t.

Country Status (23)

Country Link
US (1) US11866430B2 (es)
EP (1) EP3814347B1 (es)
JP (1) JP7373512B2 (es)
KR (1) KR20210024587A (es)
CN (1) CN112585139B (es)
AU (1) AU2019291792B2 (es)
BR (1) BR112020026568A2 (es)
CA (1) CA3104647A1 (es)
DK (1) DK3814347T3 (es)
EA (1) EA202190137A1 (es)
ES (1) ES2950007T3 (es)
FI (1) FI3814347T3 (es)
HR (1) HRP20230627T1 (es)
HU (1) HUE062412T2 (es)
IL (1) IL279730B2 (es)
LT (1) LT3814347T (es)
MX (1) MX2020013373A (es)
PL (1) PL3814347T3 (es)
PT (1) PT3814347T (es)
RS (1) RS64285B1 (es)
SG (1) SG11202012973RA (es)
SI (1) SI3814347T1 (es)
WO (1) WO2020006016A1 (es)

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AR120823A1 (es) 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t
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Also Published As

Publication number Publication date
CN112585139A (zh) 2021-03-30
JP7373512B2 (ja) 2023-11-02
SG11202012973RA (en) 2021-01-28
IL279730A (en) 2021-03-01
EA202190137A1 (ru) 2021-05-17
SI3814347T1 (sl) 2023-07-31
PT3814347T (pt) 2023-07-18
PL3814347T3 (pl) 2023-07-24
IL279730B2 (en) 2023-12-01
ES2950007T3 (es) 2023-10-04
CN112585139B (zh) 2023-12-01
AU2019291792B2 (en) 2022-09-29
EP3814347A1 (en) 2021-05-05
US20210277004A1 (en) 2021-09-09
DK3814347T3 (da) 2023-08-07
AU2019291792A1 (en) 2021-02-11
RS64285B1 (sr) 2023-07-31
LT3814347T (lt) 2023-07-10
HUE062412T2 (hu) 2023-10-28
KR20210024587A (ko) 2021-03-05
CA3104647A1 (en) 2020-01-02
US11866430B2 (en) 2024-01-09
IL279730B1 (en) 2023-08-01
BR112020026568A2 (pt) 2021-03-23
EP3814347B1 (en) 2023-05-03
HRP20230627T1 (hr) 2023-09-29
WO2020006016A1 (en) 2020-01-02
JP2021528469A (ja) 2021-10-21
FI3814347T3 (fi) 2023-06-12

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