MX2020013347A - Polimerasas, composiciones y metodos de uso. - Google Patents
Polimerasas, composiciones y metodos de uso.Info
- Publication number
- MX2020013347A MX2020013347A MX2020013347A MX2020013347A MX2020013347A MX 2020013347 A MX2020013347 A MX 2020013347A MX 2020013347 A MX2020013347 A MX 2020013347A MX 2020013347 A MX2020013347 A MX 2020013347A MX 2020013347 A MX2020013347 A MX 2020013347A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- polymerases
- compositions
- incorporation
- altered
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 238000010348 incorporation Methods 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/07—Nucleotidyltransferases (2.7.7)
- C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/101—DNA polymerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
Abstract
En la presente se presentan enzimas de polimerasa alteradas para la incorporación mejorada de nucleótidos y análogos de nucleótidos, en particular polimerasas alteradas que mantienen alta fidelidad bajo tiempos de incorporación reducidos, así como métodos y kits que utilizan los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862753558P | 2018-10-31 | 2018-10-31 | |
PCT/US2019/059246 WO2020092830A1 (en) | 2018-10-31 | 2019-10-31 | Polymerases, compositions, and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020013347A true MX2020013347A (es) | 2021-04-28 |
Family
ID=68621372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020013347A MX2020013347A (es) | 2018-10-31 | 2019-10-31 | Polimerasas, composiciones y metodos de uso. |
Country Status (13)
Country | Link |
---|---|
US (3) | US11104888B2 (es) |
EP (1) | EP3874036A1 (es) |
JP (1) | JP2022503427A (es) |
KR (1) | KR20210084349A (es) |
CN (1) | CN112673098B (es) |
AU (1) | AU2019374098A1 (es) |
BR (1) | BR112020026658A2 (es) |
CA (1) | CA3103719A1 (es) |
IL (2) | IL299237A (es) |
MX (1) | MX2020013347A (es) |
SG (1) | SG11202012493WA (es) |
WO (1) | WO2020092830A1 (es) |
ZA (1) | ZA202007838B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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MX2020013347A (es) | 2018-10-31 | 2021-04-28 | Illumina Inc | Polimerasas, composiciones y metodos de uso. |
WO2020117968A2 (en) | 2018-12-05 | 2020-06-11 | Illumina, Inc. | Polymerases, compositions, and methods of use |
US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
AU2020412459B2 (en) | 2019-12-23 | 2022-12-08 | Singular Genomics Systems, Inc. | Methods for long read sequencing |
CA3166578A1 (en) | 2019-12-31 | 2021-07-08 | Singular Genomics Systems, Inc. | Polynucleotide barcodes for long read sequencing |
EP4117682A4 (en) | 2020-04-24 | 2023-09-13 | Singular Genomics Systems, Inc. | MODIFIED NUCLEOTIDES AND THEIR USES |
MA58991A1 (fr) | 2020-06-22 | 2023-03-31 | Illumina Cambridge Ltd | Nucléosides et nucléotides avec groupe de blocage acétal 3' |
US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
US20220195518A1 (en) | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
EP4334327A1 (en) | 2021-05-05 | 2024-03-13 | Illumina Cambridge Limited | Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing |
KR20240009435A (ko) | 2021-05-20 | 2024-01-22 | 일루미나, 인코포레이티드 | 합성에 의한 시퀀싱을 위한 조성물 및 방법 |
US20230265402A1 (en) | 2022-02-18 | 2023-08-24 | Element Biosciences, Inc. | Engineered polymerases with reduced sequence-specific errors |
WO2023186815A1 (en) | 2022-03-28 | 2023-10-05 | Illumina Cambridge Limited | Labeled avidin and methods for sequencing |
US20230313292A1 (en) | 2022-03-29 | 2023-10-05 | Illumina Cambridge Limited | Chromenoquinoline dyes and uses in sequencing |
AU2023246691A1 (en) | 2022-03-30 | 2024-01-18 | Illumina, Inc. | Methods for chemical cleavage of surface-bound polynucleotides |
CA3223128A1 (en) | 2022-03-31 | 2023-10-05 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
WO2023192900A1 (en) | 2022-03-31 | 2023-10-05 | Illumina Singapore Pte. Ltd. | Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis |
WO2023232829A1 (en) | 2022-05-31 | 2023-12-07 | Illumina, Inc | Compositions and methods for nucleic acid sequencing |
WO2024003087A1 (en) | 2022-06-28 | 2024-01-04 | Illumina, Inc. | Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing |
WO2024068971A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Polymerases, compositions, and methods of use |
WO2024068889A2 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Compositions and methods for reducing photo damage during sequencing |
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MX2020013347A (es) * | 2018-10-31 | 2021-04-28 | Illumina Inc | Polimerasas, composiciones y metodos de uso. |
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-
2019
- 2019-10-31 MX MX2020013347A patent/MX2020013347A/es unknown
- 2019-10-31 KR KR1020207037274A patent/KR20210084349A/ko unknown
- 2019-10-31 US US16/670,876 patent/US11104888B2/en active Active
- 2019-10-31 JP JP2020572427A patent/JP2022503427A/ja active Pending
- 2019-10-31 IL IL299237A patent/IL299237A/en unknown
- 2019-10-31 CN CN201980043453.3A patent/CN112673098B/zh active Active
- 2019-10-31 BR BR112020026658-2A patent/BR112020026658A2/pt unknown
- 2019-10-31 AU AU2019374098A patent/AU2019374098A1/en active Pending
- 2019-10-31 WO PCT/US2019/059246 patent/WO2020092830A1/en unknown
- 2019-10-31 EP EP19806368.7A patent/EP3874036A1/en active Pending
- 2019-10-31 CA CA3103719A patent/CA3103719A1/en active Pending
- 2019-10-31 SG SG11202012493WA patent/SG11202012493WA/en unknown
-
2020
- 2020-12-13 IL IL279422A patent/IL279422B2/en unknown
- 2020-12-15 ZA ZA2020/07838A patent/ZA202007838B/en unknown
-
2021
- 2021-08-09 US US17/397,003 patent/US11560552B2/en active Active
-
2022
- 2022-12-21 US US18/085,674 patent/US20230212534A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112020026658A2 (pt) | 2021-08-10 |
AU2019374098A1 (en) | 2021-01-07 |
US20230212534A1 (en) | 2023-07-06 |
CA3103719A1 (en) | 2020-05-07 |
WO2020092830A1 (en) | 2020-05-07 |
IL279422A (en) | 2021-01-31 |
SG11202012493WA (en) | 2021-01-28 |
KR20210084349A (ko) | 2021-07-07 |
CN112673098A (zh) | 2021-04-16 |
IL279422B2 (en) | 2023-05-01 |
US11560552B2 (en) | 2023-01-24 |
US20220056424A1 (en) | 2022-02-24 |
IL279422B1 (en) | 2023-01-01 |
US11104888B2 (en) | 2021-08-31 |
CN112673098B (zh) | 2023-01-06 |
JP2022503427A (ja) | 2022-01-12 |
ZA202007838B (en) | 2023-04-26 |
EP3874036A1 (en) | 2021-09-08 |
US20200131484A1 (en) | 2020-04-30 |
IL299237A (en) | 2023-02-01 |
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