MX2020010461A - Linfocitos t que expresan un receptor recombinante, polinucleotidos y metodos relacionados. - Google Patents

Linfocitos t que expresan un receptor recombinante, polinucleotidos y metodos relacionados.

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Publication number
MX2020010461A
MX2020010461A MX2020010461A MX2020010461A MX2020010461A MX 2020010461 A MX2020010461 A MX 2020010461A MX 2020010461 A MX2020010461 A MX 2020010461A MX 2020010461 A MX2020010461 A MX 2020010461A MX 2020010461 A MX2020010461 A MX 2020010461A
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Mexico
Prior art keywords
receptor
methods
recombinant receptor
recombinant
cells expressing
Prior art date
Application number
MX2020010461A
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English (en)
Inventor
Christopher Borges
Stephen Michael Burleigh
Christopher Heath Nye
Blythe D Sather
Queenie Vong
Gordon Grant Welstead
Original Assignee
Juno Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2020010461A publication Critical patent/MX2020010461A/es

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    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se proporcionan en el presente documento, métodos para diseñar células inmunes, composiciones celulares que contienen las células inmunes diseñadas, equipos y artículos manufacturados para dirigir una secuencia de ácidos nucleicos que codifica una porción de un receptor recombinante, por ejemplo, un receptor de un linfocito T recombinante (TCR), a un sitio genómico particular y/o para modular la expresión del gen en el sitio genómico, y aplicaciones de los mismos, en conexión con la inmunoterapia para el cáncer, tal como transferencia adoptiva de los linfocitos T diseñados. En algunos aspectos, la secuencia de ácidos nucleicos se integra en el marco en el sitio de un gen que codifica un receptor, y en algunos aspectos, resulta en la expresión de todo el receptor recombinante.
MX2020010461A 2018-04-05 2019-04-03 Linfocitos t que expresan un receptor recombinante, polinucleotidos y metodos relacionados. MX2020010461A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862653553P 2018-04-05 2018-04-05
PCT/US2019/025681 WO2019195491A1 (en) 2018-04-05 2019-04-03 T cells expressing a recombinant receptor, related polynucleotides and methods

Publications (1)

Publication Number Publication Date
MX2020010461A true MX2020010461A (es) 2021-01-15

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Country Status (14)

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US (1) US20210015869A1 (es)
EP (1) EP3775237A1 (es)
JP (1) JP2021520211A (es)
KR (1) KR20210020873A (es)
CN (1) CN112585277A (es)
AU (1) AU2019247199A1 (es)
BR (1) BR112020020073A2 (es)
CA (1) CA3095084A1 (es)
IL (1) IL277704A (es)
MA (1) MA52207A (es)
MX (1) MX2020010461A (es)
RU (1) RU2020136054A (es)
SG (1) SG11202009446TA (es)
WO (1) WO2019195491A1 (es)

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