MX2020008195A - Compuestos para el tratamiento del dolor. - Google Patents
Compuestos para el tratamiento del dolor.Info
- Publication number
- MX2020008195A MX2020008195A MX2020008195A MX2020008195A MX2020008195A MX 2020008195 A MX2020008195 A MX 2020008195A MX 2020008195 A MX2020008195 A MX 2020008195A MX 2020008195 A MX2020008195 A MX 2020008195A MX 2020008195 A MX2020008195 A MX 2020008195A
- Authority
- MX
- Mexico
- Prior art keywords
- pain
- compounds
- treatment
- useful
- subject
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Abstract
En la presente se proporcionan compuestos que son útiles en el tratamiento del dolor en un sujeto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862626499P | 2018-02-05 | 2018-02-05 | |
PCT/US2019/016543 WO2019152946A1 (en) | 2018-02-05 | 2019-02-04 | Compounds for the treatment of pain |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020008195A true MX2020008195A (es) | 2020-11-24 |
Family
ID=65444375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020008195A MX2020008195A (es) | 2018-02-05 | 2019-02-04 | Compuestos para el tratamiento del dolor. |
Country Status (14)
Country | Link |
---|---|
US (3) | US10604489B2 (es) |
EP (1) | EP3749667A1 (es) |
JP (1) | JP2021512952A (es) |
KR (1) | KR20200136384A (es) |
CN (1) | CN111989327A (es) |
AU (1) | AU2019216522A1 (es) |
BR (1) | BR112020015712A2 (es) |
CA (1) | CA3090385A1 (es) |
EA (1) | EA202091881A1 (es) |
IL (1) | IL276482A (es) |
MA (1) | MA51738A (es) |
MX (1) | MX2020008195A (es) |
SG (1) | SG11202007422QA (es) |
WO (1) | WO2019152946A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200136384A (ko) * | 2018-02-05 | 2020-12-07 | 알케르메스, 인코포레이티드 | 통증 치료용 화합물 |
WO2021026377A1 (en) * | 2019-08-07 | 2021-02-11 | Alkermes, Inc. | Lactam-containing compounds for the treatment of pain |
WO2021026378A1 (en) * | 2019-08-07 | 2021-02-11 | Alkermes, Inc. | Indole compounds for the treatment of pain |
WO2021026380A1 (en) * | 2019-08-07 | 2021-02-11 | Alkermes, Inc. | Phenyltriazole compounds for the treatment of pain |
WO2021026375A1 (en) * | 2019-08-07 | 2021-02-11 | Alkermes, Inc. | Fused bicyclic compounds for the treatment of pain |
TW202142537A (zh) | 2020-02-04 | 2021-11-16 | 美商艾爾凱默斯公司 | 3-((1R,5S,9r)-9-乙氧基-3-氮雜雙環并[3.3.1]壬烷-9-基)—苯甲醯胺之結晶形式及其鹽形式 |
Family Cites Families (44)
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US3167562A (en) | 1965-01-26 | New j-azabicyclo | ||
GB952137A (en) | 1961-03-14 | 1964-03-11 | Sankyo Co | New 3-azabicyclo [3.3.1] nonane compounds and a process for preparing these compounds |
US3196154A (en) | 1962-05-17 | 1965-07-20 | Sterling Drug Inc | 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes |
US3475439A (en) | 1966-05-07 | 1969-10-28 | Sankyo Co | 3-azabicyclo(3.3.1)nonane compounds |
GB1195746A (en) | 1967-06-07 | 1970-06-24 | Yoshitomi Pharmaceutical | 3-Azabicyclo [3,3,1] Nonane Derivatives |
GB1393253A (en) | 1971-09-10 | 1975-05-07 | Wyeth John & Brother Ltd | 3-azabicyclo-3,3,1-nonanes |
JPS4856680A (es) | 1971-11-18 | 1973-08-09 | ||
JPS4961168A (es) | 1972-10-14 | 1974-06-13 | ||
IL59004A0 (en) * | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
WO1991018901A1 (fr) | 1990-06-05 | 1991-12-12 | Toray Industries, Inc. | Derives d'indole |
EP0483403A1 (en) | 1990-10-31 | 1992-05-06 | Hoechst Aktiengesellschaft | Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use |
DE4341403A1 (de) | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
US5541217A (en) | 1995-05-17 | 1996-07-30 | Ortho Pharmaceutical Corporation | 4-arylcyclopenta[c]pyrrole analgesics |
JP2808089B2 (ja) | 1995-08-29 | 1998-10-08 | レーザーテクノ株式会社 | 墨出し用レーザー装置 |
TWI244481B (en) | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
DE19952146A1 (de) | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
AU2003210730A1 (en) * | 2002-02-15 | 2003-09-09 | Pharmacia And Upjohn Company | Azabicyclo-substituted benzoylamides and thioamides for treatment of cns-related disorders |
EP1615894A2 (en) | 2003-04-14 | 2006-01-18 | Pfizer Products Inc. | 3-azabicyclo 3.2.1 octane derivatives |
US7056930B2 (en) | 2003-04-14 | 2006-06-06 | Pfizer Inc. | 2-Azabicyclo[3.3.1]nonane derivatives |
PL1678172T3 (pl) | 2003-10-15 | 2010-05-31 | Targacept Inc | Związki azabicykliczne do łagodzenia bólu oraz leczenia zaburzeń centralnego układu nerwowego |
CN101005838A (zh) | 2004-06-22 | 2007-07-25 | 先灵公司 | ***素受体配体 |
WO2007029156A2 (en) | 2005-09-05 | 2007-03-15 | Ranbaxy Laboratories Limited | Isoindoledione derivatives as adrenergic receptor antagonists |
US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
US7488726B2 (en) | 2005-11-03 | 2009-02-10 | Activbiotics Pharma, Llc | Rifamycin analogs and uses thereof |
MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
FR2918986B1 (fr) | 2007-07-19 | 2009-09-04 | Sanofi Aventis Sa | Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique |
TWI423801B (zh) | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之8-氮雜雙環〔3.2.1〕辛基-2-羥基苯甲醯胺化合物 |
US8048895B2 (en) | 2008-04-18 | 2011-11-01 | Research Triangle Institute | Kappa opioid receptor ligands |
GB0815947D0 (en) | 2008-09-02 | 2008-10-08 | Univ Dundee | Compounds |
EP2485735B1 (en) | 2009-10-08 | 2015-07-29 | Merck Sharp & Dohme Corp. | Inhibitors of fatty acid binding protein (fabp) |
FR2953839A1 (fr) | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
TW201209054A (en) | 2010-05-28 | 2012-03-01 | Prosidion Ltd | Novel compounds |
JP5713367B2 (ja) | 2010-06-04 | 2015-05-07 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Lrrk2モジュレーターとしてのアミノピリミジン誘導体 |
WO2012075232A1 (en) | 2010-12-04 | 2012-06-07 | Trevena, Inc. | Opioid receptor ligands and methods of using and making the same |
CN103702561B (zh) | 2011-03-23 | 2017-02-22 | 特维娜有限公司 | 阿片样物质受体配体以及使用和制备其的方法 |
JP2014237589A (ja) | 2011-09-28 | 2014-12-18 | 日本曹達株式会社 | 環状アミン化合物および有害生物防除剤 |
GB2498976A (en) | 2012-02-01 | 2013-08-07 | Prosidion Ltd | GPR119 agonists useful in the treatment of type II diabetes |
JP2015083543A (ja) | 2012-02-14 | 2015-04-30 | 大日本住友製薬株式会社 | 新規縮環ピロリジン誘導体 |
WO2014194519A1 (en) | 2013-06-07 | 2014-12-11 | Merck Sharp & Dohme Corp. | Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug |
WO2015091931A1 (en) | 2013-12-20 | 2015-06-25 | AbbVie Deutschland GmbH & Co. KG | Oxindole derivatives carrying a piperidyl-substituted azetidinyl substituent and use thereof for treating vasopressine-related diseases |
NO2721710T3 (es) | 2014-08-21 | 2018-03-31 | ||
EP3506983B1 (en) | 2016-09-01 | 2021-08-25 | Mebias Discovery, Inc. | Substituted urea-derivatives for the treatment of pain |
WO2018136546A1 (en) | 2017-01-17 | 2018-07-26 | Mebias Discovery Llc | Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same |
KR20200136384A (ko) * | 2018-02-05 | 2020-12-07 | 알케르메스, 인코포레이티드 | 통증 치료용 화합물 |
-
2019
- 2019-02-04 KR KR1020207025543A patent/KR20200136384A/ko not_active Application Discontinuation
- 2019-02-04 JP JP2020564036A patent/JP2021512952A/ja active Pending
- 2019-02-04 CN CN201980021811.0A patent/CN111989327A/zh active Pending
- 2019-02-04 BR BR112020015712-0A patent/BR112020015712A2/pt not_active Application Discontinuation
- 2019-02-04 EP EP19705893.6A patent/EP3749667A1/en not_active Withdrawn
- 2019-02-04 US US16/267,025 patent/US10604489B2/en active Active
- 2019-02-04 SG SG11202007422QA patent/SG11202007422QA/en unknown
- 2019-02-04 MA MA051738A patent/MA51738A/fr unknown
- 2019-02-04 AU AU2019216522A patent/AU2019216522A1/en not_active Abandoned
- 2019-02-04 CA CA3090385A patent/CA3090385A1/en active Pending
- 2019-02-04 EA EA202091881A patent/EA202091881A1/ru unknown
- 2019-02-04 WO PCT/US2019/016543 patent/WO2019152946A1/en unknown
- 2019-02-04 MX MX2020008195A patent/MX2020008195A/es unknown
-
2020
- 2020-02-13 US US16/790,224 patent/US11180455B2/en active Active
- 2020-08-04 IL IL276482A patent/IL276482A/en unknown
-
2021
- 2021-10-12 US US17/499,686 patent/US20220033394A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20200255383A1 (en) | 2020-08-13 |
US10604489B2 (en) | 2020-03-31 |
EA202091881A1 (ru) | 2020-11-10 |
IL276482A (en) | 2020-09-30 |
EP3749667A1 (en) | 2020-12-16 |
JP2021512952A (ja) | 2021-05-20 |
WO2019152946A1 (en) | 2019-08-08 |
MA51738A (fr) | 2021-05-12 |
US20190241524A1 (en) | 2019-08-08 |
CA3090385A1 (en) | 2019-08-08 |
AU2019216522A1 (en) | 2020-08-27 |
US11180455B2 (en) | 2021-11-23 |
KR20200136384A (ko) | 2020-12-07 |
US20220033394A1 (en) | 2022-02-03 |
BR112020015712A2 (pt) | 2020-12-08 |
CN111989327A (zh) | 2020-11-24 |
SG11202007422QA (en) | 2020-09-29 |
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