MX2020006173A - Derivados glucosidicos de treprostinilo. - Google Patents

Derivados glucosidicos de treprostinilo.

Info

Publication number
MX2020006173A
MX2020006173A MX2020006173A MX2020006173A MX2020006173A MX 2020006173 A MX2020006173 A MX 2020006173A MX 2020006173 A MX2020006173 A MX 2020006173A MX 2020006173 A MX2020006173 A MX 2020006173A MX 2020006173 A MX2020006173 A MX 2020006173A
Authority
MX
Mexico
Prior art keywords
treprostinil
glycosidic
derivatives
glycosidic derivatives
hypertension
Prior art date
Application number
MX2020006173A
Other languages
English (en)
Inventor
Josef Spreitz
Wolfgang Strohmaier
Original Assignee
Aop Orphan Ip Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aop Orphan Ip Ag filed Critical Aop Orphan Ip Ag
Publication of MX2020006173A publication Critical patent/MX2020006173A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings

Abstract

La presente invención se refiere al campo de productos farmacéuticos, en específico los derivados glucosídicos de treprostinilo. Los derivados glucosídicos de treprostinilo se pueden utilizar para tratar cualquier condición que responde al tratamiento con treprostinilo, incluyendo hipertensión pulmonar, tal como hipertensión arterial pulmonar.
MX2020006173A 2017-12-14 2018-12-13 Derivados glucosidicos de treprostinilo. MX2020006173A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17207329.8A EP3498283A1 (en) 2017-12-14 2017-12-14 Glycosidic derivatives of treprostinil
PCT/EP2018/084779 WO2019115702A1 (en) 2017-12-14 2018-12-13 Glycosidic derivatives of treprostinil

Publications (1)

Publication Number Publication Date
MX2020006173A true MX2020006173A (es) 2020-10-12

Family

ID=60673569

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006173A MX2020006173A (es) 2017-12-14 2018-12-13 Derivados glucosidicos de treprostinilo.

Country Status (15)

Country Link
US (1) US11427609B2 (es)
EP (2) EP3498283A1 (es)
JP (1) JP7295877B2 (es)
KR (1) KR20200099134A (es)
CN (1) CN111447933A (es)
AU (1) AU2018382556B2 (es)
BR (1) BR112020010945A2 (es)
CA (1) CA3085398A1 (es)
CL (1) CL2020001559A1 (es)
IL (1) IL275127B2 (es)
MX (1) MX2020006173A (es)
RU (1) RU2020119175A (es)
SG (1) SG11202005360TA (es)
WO (1) WO2019115702A1 (es)
ZA (1) ZA202002725B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023529828A (ja) 2020-06-09 2023-07-12 ユナイテッド セラピューティクス コーポレイション トレプロスチニルのフマリルジケトピペリジンプロドラッグ

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814438D0 (en) 1988-06-17 1988-07-20 Wellcome Found Compounds for use in medicine
US6521212B1 (en) 1999-03-18 2003-02-18 United Therapeutics Corporation Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation
CN1354622A (zh) 1999-03-31 2002-06-19 联合治疗公司 ***素类化合物、组合物和治疗外周血管疾病和肺动脉高压的方法
US20030108512A1 (en) 2001-12-10 2003-06-12 Robert Shorr Modified prostaglandin compounds and analogs thereof, compositions containing the same useful for the treatment of cancer
US7417070B2 (en) * 2003-05-22 2008-08-26 United Therapeutics Corporation Compounds and methods for delivery of prostacyclin analogs
EA016568B1 (ru) 2006-10-12 2012-05-30 Беллус Хелс (Интернэшнл) Лимитед Способы, соединения, композиции и носители для доставки 3-амино-1-пропансульфоновой кислоты
HUE031652T2 (en) 2011-02-07 2017-07-28 Scipharm Sarl New composition for treating cystic fibrosis
MX349950B (es) 2011-08-12 2017-08-22 Ascendis Pharma As Profarmacos de treprostinil enlazados a un portador.
RS56304B1 (sr) 2012-06-15 2017-12-29 Scipharm Sarl Postupak za pripremu treprostinila i njegovih derivata
AU2013355130B2 (en) 2012-12-07 2018-06-21 Cayman Chemical Company Incorporated Methods of synthesizing a prostacyclin analog
US9371264B2 (en) 2013-01-11 2016-06-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9505737B2 (en) * 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
JP2018503654A (ja) 2015-01-27 2018-02-08 サイファーム ソシエテ ア レスポンサビリテ リミテＳｃｉＰｈａｒｍＳ．ａ ｒ．ｌ． 肝静脈閉塞症の処置のための組成物
US9394227B1 (en) * 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof

Also Published As

Publication number Publication date
AU2018382556A1 (en) 2020-05-28
JP2021506959A (ja) 2021-02-22
KR20200099134A (ko) 2020-08-21
CN111447933A (zh) 2020-07-24
JP7295877B2 (ja) 2023-06-21
RU2020119175A3 (es) 2022-01-14
IL275127B1 (en) 2023-07-01
US20210087216A1 (en) 2021-03-25
EP3498283A1 (en) 2019-06-19
IL275127A (en) 2020-07-30
US11427609B2 (en) 2022-08-30
WO2019115702A1 (en) 2019-06-20
SG11202005360TA (en) 2020-07-29
EP3723769A1 (en) 2020-10-21
AU2018382556B2 (en) 2024-03-14
IL275127B2 (en) 2023-11-01
RU2020119175A (ru) 2022-01-14
CL2020001559A1 (es) 2021-03-12
CA3085398A1 (en) 2019-06-20
ZA202002725B (en) 2021-08-25
BR112020010945A2 (pt) 2020-11-17

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