MX2020003751A - Método seguro y eficaz para tratar el lupus con anticuerpo anti-il12/il23. - Google Patents

Método seguro y eficaz para tratar el lupus con anticuerpo anti-il12/il23.

Info

Publication number
MX2020003751A
MX2020003751A MX2020003751A MX2020003751A MX2020003751A MX 2020003751 A MX2020003751 A MX 2020003751A MX 2020003751 A MX2020003751 A MX 2020003751A MX 2020003751 A MX2020003751 A MX 2020003751A MX 2020003751 A MX2020003751 A MX 2020003751A
Authority
MX
Mexico
Prior art keywords
antibody
safe
effective method
treating lupus
patient
Prior art date
Application number
MX2020003751A
Other languages
English (en)
Inventor
Shawn Rose
Carrie Wagner
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MX2020003751A publication Critical patent/MX2020003751A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Abstract

Un método para tratar el lupus eritematoso sistémico (LES) activo en un paciente en el que se administra una cantidad comprobada clínicamente como segura y comprobada clínicamente como eficaz de un anticuerpo anti-IL-12/IL-23p40 o un anticuerpo anti-IL-23, p. ej., el anticuerpo anti-IL-12/IL-23p40 ustekinumab, en donde el paciente logra una mejoría significativa en la actividad de la enfermedad.
MX2020003751A 2017-09-25 2018-09-24 Método seguro y eficaz para tratar el lupus con anticuerpo anti-il12/il23. MX2020003751A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762562701P 2017-09-25 2017-09-25
US201762585858P 2017-11-14 2017-11-14
US201862730748P 2018-09-13 2018-09-13
PCT/IB2018/057368 WO2019058345A2 (en) 2017-09-25 2018-09-24 SAFE AND EFFECTIVE METHOD OF TREATING LUPUS WITH ANTI-IL12 / IL23 ANTIBODY

Publications (1)

Publication Number Publication Date
MX2020003751A true MX2020003751A (es) 2020-11-09

Family

ID=65808646

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003751A MX2020003751A (es) 2017-09-25 2018-09-24 Método seguro y eficaz para tratar el lupus con anticuerpo anti-il12/il23.

Country Status (11)

Country Link
US (1) US20190092853A1 (es)
EP (1) EP3687563A4 (es)
JP (2) JP2020535149A (es)
KR (1) KR20200057072A (es)
AU (1) AU2018335614A1 (es)
CA (1) CA3044777C (es)
IL (1) IL273475A (es)
MA (1) MA50666A (es)
MX (1) MX2020003751A (es)
TW (1) TW201922780A (es)
WO (1) WO2019058345A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11578124B2 (en) 2018-05-18 2023-02-14 Janssen Biotech, Inc. Safe and effective method of treating lupus with anti-IL12/IL23 antibody
EP3897722A4 (en) 2018-12-18 2022-09-14 Janssen Biotech, Inc. SAFE AND EFFECTIVE METHOD OF TREATING LUPUS WITH AN ANTI-IL12/IL23 ANTIBODY
WO2021074897A2 (en) * 2019-10-18 2021-04-22 Janssen Biotech, Inc. Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody
AU2021218265A1 (en) * 2020-02-14 2022-10-06 Janssen Biotech, Inc. Safe and effective method of treating ulcerative colitis with anti-IL-12/IL23 antibody

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