MX2020003224A - Moduladores de receptor nuclear. - Google Patents

Moduladores de receptor nuclear.

Info

Publication number
MX2020003224A
MX2020003224A MX2020003224A MX2020003224A MX2020003224A MX 2020003224 A MX2020003224 A MX 2020003224A MX 2020003224 A MX2020003224 A MX 2020003224A MX 2020003224 A MX2020003224 A MX 2020003224A MX 2020003224 A MX2020003224 A MX 2020003224A
Authority
MX
Mexico
Prior art keywords
receptor modulators
nuclear receptor
compounds
variable
useful
Prior art date
Application number
MX2020003224A
Other languages
English (en)
Inventor
Kevin P Cusack
Eric C Breinlinger
Michael E Kort
Maria A Argiriadi
Dominique Potin
Martine Barth
Olivia Poupardin
Laurent Mounier
Adrian D Hobson
Jérôme Amaudrut
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2015/001693 external-priority patent/WO2016198908A1/en
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2020003224A publication Critical patent/MX2020003224A/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

La invención proporciona compuestos de Fórmula (I) (ver Fórmula) sales farmacéuticamente aceptables de los mismos, en la que la variable se define en el presente documento. Los compuestos de la invención son útiles para tratar afecciones inmunológicas.
MX2020003224A 2015-06-09 2017-12-07 Moduladores de receptor nuclear. MX2020003224A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/IB2015/001693 WO2016198908A1 (en) 2015-06-09 2015-06-09 Ror nuclear receptor modulators
US201562257806P 2015-11-20 2015-11-20
US201662343905P 2016-06-01 2016-06-01

Publications (1)

Publication Number Publication Date
MX2020003224A true MX2020003224A (es) 2020-07-29

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MX2017015980A MX2017015980A (es) 2015-06-09 2016-06-08 Moduladores de receptor nuclear.
MX2020003224A MX2020003224A (es) 2015-06-09 2017-12-07 Moduladores de receptor nuclear.

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MX2017015980A MX2017015980A (es) 2015-06-09 2016-06-08 Moduladores de receptor nuclear.

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