MX2020001590A - Agonistas del receptor de glp-1/glucagon en el tratamiento de la enfermedad del higado graso y la esteatohepetitis. - Google Patents

Agonistas del receptor de glp-1/glucagon en el tratamiento de la enfermedad del higado graso y la esteatohepetitis.

Info

Publication number
MX2020001590A
MX2020001590A MX2020001590A MX2020001590A MX2020001590A MX 2020001590 A MX2020001590 A MX 2020001590A MX 2020001590 A MX2020001590 A MX 2020001590A MX 2020001590 A MX2020001590 A MX 2020001590A MX 2020001590 A MX2020001590 A MX 2020001590A
Authority
MX
Mexico
Prior art keywords
time
liver disease
fatty liver
nafld
treatment
Prior art date
Application number
MX2020001590A
Other languages
English (en)
Inventor
Haack Torsten
Elvert Ralf
Wagner Michael
Kannt Aimo
Bielohuby Maximilian
Bossart Martin
Keil Stephanie
Seiz Werner
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2020001590A publication Critical patent/MX2020001590A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

La presente invención se refiere al uso médico de agonistas específicos del receptor de GLP-1/glucagón en la prevención y/o tratamiento de la enfermedad hepática metabólica, particularmente enfermedad del hígado graso no alcohólico (NAFLD), más particularmente hígado graso no alcohólico (NAFL), esteatohepatitis no alcohólica (NASH) y/o fibrosis hepática asociada a NAFLD.
MX2020001590A 2017-08-09 2018-08-08 Agonistas del receptor de glp-1/glucagon en el tratamiento de la enfermedad del higado graso y la esteatohepetitis. MX2020001590A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17306059 2017-08-09
PCT/EP2018/071478 WO2019030268A1 (en) 2017-08-09 2018-08-08 GLP-1 / GLUCAGON RECEPTOR AGONISTS FOR THE TREATMENT OF HEPATIC STEATOSIS AND STÉATOHÉPATITE

Publications (1)

Publication Number Publication Date
MX2020001590A true MX2020001590A (es) 2020-03-20

Family

ID=59761892

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020001590A MX2020001590A (es) 2017-08-09 2018-08-08 Agonistas del receptor de glp-1/glucagon en el tratamiento de la enfermedad del higado graso y la esteatohepetitis.

Country Status (15)

Country Link
US (1) US11352405B2 (es)
EP (1) EP3664833B1 (es)
JP (1) JP7230002B2 (es)
KR (1) KR20200037358A (es)
CN (1) CN111032071A (es)
AU (1) AU2018314773A1 (es)
BR (1) BR112020002503A2 (es)
CA (1) CA3072118A1 (es)
ES (1) ES2953631T3 (es)
IL (1) IL272457A (es)
MX (1) MX2020001590A (es)
RU (1) RU2020109881A (es)
SG (1) SG11202000941YA (es)
TW (1) TW201920240A (es)
WO (1) WO2019030268A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112442114A (zh) * 2019-08-29 2021-03-05 渥太华Hdl药物研发公司 一种多肽及其应用
WO2021204755A1 (en) 2020-04-06 2021-10-14 Poxel Pharmaceutical combination for the treatment of liver diseases
MX2022013230A (es) 2020-04-24 2022-11-14 Boehringer Ingelheim Int Analogos de glucagon como agonistas de accion prolongada del receptor de glp-1/glucagon para usarse en el tratamiento de enfermedad del higado graso y esteatohepatitis.
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
CN112472794A (zh) * 2020-11-17 2021-03-12 深圳市图微安创科技开发有限公司 双靶点激动剂多肽治疗anit介导的pbc及其相关的肝纤维化
CN117677395A (zh) * 2021-07-30 2024-03-08 勃林格殷格翰国际有限公司 长效glp1/胰高血糖素受体激动剂的剂量方案

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2127676A3 (en) * 2004-11-01 2013-09-04 Amylin Pharmaceuticals, LLC Treatment of obesity and related disorders
KR101968344B1 (ko) * 2012-07-25 2019-04-12 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
AR094181A1 (es) 2012-12-21 2015-07-15 Sanofi Sa Agonistas duales de glp1/gip o trigonales de glp1/gip/glucagon
TW201625668A (zh) * 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
BR112017008160A8 (pt) * 2014-10-24 2023-04-11 Merck Sharp & Dohme Peptídeo, composição, métodos para tratamento de um paciente ou indivíduo e para tratamento de uma doença metabólica, e, usos de um peptídeo e de uma composição
US10752693B2 (en) * 2015-04-02 2020-08-25 Remd Biotherapeutics, Inc. Methods for treating obesity and nonalcoholic fatty liver disease or nonalcoholic steatohepatitis using glucagon receptor antagonistic antibodies
WO2016198628A1 (en) * 2015-06-12 2016-12-15 Sanofi Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists
WO2016198624A1 (en) 2015-06-12 2016-12-15 Sanofi Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
TWI622596B (zh) 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
CN115181175A (zh) * 2016-04-22 2022-10-14 深圳市图微安创科技开发有限公司 Glp-1r/gcgr双靶点激动剂多肽治疗脂肪肝病、高脂血症和动脉硬化
TW201832783A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 包含ｇｌｐ－１／胰高血糖素雙重激動劑、連接子和透明質酸的接合物

Also Published As

Publication number Publication date
US20200216510A1 (en) 2020-07-09
JP2020530017A (ja) 2020-10-15
WO2019030268A1 (en) 2019-02-14
SG11202000941YA (en) 2020-02-27
US11352405B2 (en) 2022-06-07
TW201920240A (zh) 2019-06-01
CA3072118A1 (en) 2019-02-14
JP7230002B2 (ja) 2023-02-28
AU2018314773A1 (en) 2020-03-26
EP3664833A1 (en) 2020-06-17
IL272457A (en) 2020-03-31
RU2020109881A (ru) 2021-09-10
RU2020109881A3 (es) 2021-12-15
EP3664833B1 (en) 2023-05-31
BR112020002503A2 (pt) 2020-08-18
ES2953631T3 (es) 2023-11-14
CN111032071A (zh) 2020-04-17
KR20200037358A (ko) 2020-04-08

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