MX2020001272A - Anticuerpos dirigidos contra interleucina-33 (il-33). - Google Patents
Anticuerpos dirigidos contra interleucina-33 (il-33).Info
- Publication number
- MX2020001272A MX2020001272A MX2020001272A MX2020001272A MX2020001272A MX 2020001272 A MX2020001272 A MX 2020001272A MX 2020001272 A MX2020001272 A MX 2020001272A MX 2020001272 A MX2020001272 A MX 2020001272A MX 2020001272 A MX2020001272 A MX 2020001272A
- Authority
- MX
- Mexico
- Prior art keywords
- chain polypeptide
- directed against
- antibodies directed
- against interleukin
- binding agent
- Prior art date
Links
- 102000017761 Interleukin-33 Human genes 0.000 title abstract 6
- 108010067003 Interleukin-33 Proteins 0.000 title abstract 6
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 abstract 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a un polipéptido de cadena pesada de inmunoglobulina aislado y un polipéptido de cadena ligera de inmunoglobulina aislado que se enlazan a interleucina-33 (IL-33). La invención proporciona un agente de enlace a IL-33 que comprende el polipéptido de cadena pesada de inmunoglobulina y el polipéptido de cadena ligera de inmunoglobulina anteriormente mencionados. La invención también proporciona vectores, composiciones, y métodos relacionados al uso del agente de enlace a IL-33 para tratar un trastorno en un mamífero que responde a inhibición de IL-33.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461925946P | 2014-01-10 | 2014-01-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020001272A true MX2020001272A (es) | 2020-07-20 |
Family
ID=53524474
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016009047A MX2016009047A (es) | 2014-01-10 | 2015-01-09 | Anticuerpos dirigidos contra interleucina-33 (il-33). |
MX2020001272A MX2020001272A (es) | 2014-01-10 | 2016-07-08 | Anticuerpos dirigidos contra interleucina-33 (il-33). |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016009047A MX2016009047A (es) | 2014-01-10 | 2015-01-09 | Anticuerpos dirigidos contra interleucina-33 (il-33). |
Country Status (14)
Country | Link |
---|---|
US (3) | US10059764B2 (es) |
EP (1) | EP3092253B1 (es) |
JP (2) | JP2017503506A (es) |
KR (1) | KR102446386B1 (es) |
CN (1) | CN106103480B (es) |
AU (1) | AU2015204674B2 (es) |
BR (1) | BR112016016020B1 (es) |
CA (1) | CA2936366A1 (es) |
ES (1) | ES2866935T3 (es) |
MX (2) | MX2016009047A (es) |
NZ (1) | NZ722445A (es) |
RU (2) | RU2693084C2 (es) |
SG (2) | SG11201605580RA (es) |
WO (1) | WO2015106080A2 (es) |
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DK2371865T3 (en) | 2006-04-07 | 2017-10-23 | Aerpio Therapeutics Inc | Antibodies that bind human protein tyrosine phosphatase beta (HPTP-β) and uses thereof |
JO3532B1 (ar) | 2013-03-13 | 2020-07-05 | Regeneron Pharma | الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها |
US9637535B2 (en) | 2013-03-15 | 2017-05-02 | Regeneron Pharmaceuticals, Inc. | IL-33 antagonists and uses thereof |
BR112016013347B1 (pt) | 2013-12-26 | 2023-12-12 | Mitsubishi Tanabe Pharma Corporation | Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos |
AU2015204674B2 (en) | 2014-01-10 | 2020-09-03 | Anaptysbio, Inc. | Antibodies directed against interleukin-33 (IL-33) |
US11708608B2 (en) | 2014-11-10 | 2023-07-25 | Genentech, Inc. | Therapeutic and diagnostic methods for IL-33-mediated disorders |
EA201791029A1 (ru) | 2014-11-10 | 2017-12-29 | Дженентек, Инк. | Антитела против интерлейкина-33 и их применение |
EP3402521A4 (en) * | 2016-01-14 | 2019-11-20 | AnaptysBio, Inc. | INHIBITION OF ALLERGIC REACTION USING AN IL-33 INHIBITOR |
CN109415436A (zh) * | 2016-04-27 | 2019-03-01 | 辉瑞公司 | 抗il-33抗体及其组合物、方法及用途 |
KR20190031246A (ko) * | 2016-07-20 | 2019-03-25 | 에르피오 세러퓨틱스 인코포레이티드 | VE-PTP (HPTP-β)를 표적으로 하는 인간화된 단클론성 항체 |
JOP20190093A1 (ar) * | 2016-10-28 | 2019-04-25 | Lilly Co Eli | أجسام مضادة لـ il-33 واستخداماتها |
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CN110431240A (zh) | 2017-04-13 | 2019-11-08 | 雷杰纳荣制药公司 | 在编码il33和il1rl1的基因中具有风险等位基因的患者的炎症性肺部疾病的治疗和抑制 |
TWI825025B (zh) | 2017-08-31 | 2023-12-11 | 日商田邊三菱製藥股份有限公司 | 包含il-33拮抗劑的子宮內膜異位症治療劑 |
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AU2019218128A1 (en) | 2018-02-09 | 2020-09-17 | Genentech, Inc. | Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases |
WO2019183639A1 (en) * | 2018-03-23 | 2019-09-26 | Anaptysbio, Inc. | Inhibition of allergic reaction to peanut allergen using an il-33 inhibitor |
IL307286A (en) | 2018-04-11 | 2023-11-01 | Regeneron Pharma | Methods and preparations for quantification of IL-33 |
TW202021983A (zh) | 2018-09-21 | 2020-06-16 | 美商安納普提斯生物公司 | 用於嗜伊紅性氣喘之抗il-33療法 |
CN113164597A (zh) | 2018-09-24 | 2021-07-23 | 爱尔皮奥制药公司 | 靶向HPTP-β(VE-PTP)和VEGF的多特异性抗体 |
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CA3176571A1 (en) | 2020-04-06 | 2021-10-14 | Medimmune Limited | Treating acute respiratory distress syndrome with il-33 axis binding antagonists |
CA3181765A1 (en) | 2020-05-11 | 2021-11-18 | Medimmune Limited | Formulations of anti-il-33 antibodies |
US20210380721A1 (en) * | 2020-06-01 | 2021-12-09 | University Of Kentucky Research Foundation | Compounds and methods for use in connection with opioid use disorders |
US20230255954A1 (en) * | 2020-07-07 | 2023-08-17 | The General Hospital Corporation | Interleukin 33 (il-33) inhibition for treatment of cancer, fibrosis and inflammation |
KR20220022226A (ko) * | 2020-08-18 | 2022-02-25 | 성균관대학교산학협력단 | Il-33 항체 또는 이의 항원 결합 단편 |
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US20210040198A1 (en) | 2021-02-11 |
BR112016016020A2 (pt) | 2018-05-22 |
WO2015106080A2 (en) | 2015-07-16 |
US20180346562A1 (en) | 2018-12-06 |
MX2016009047A (es) | 2017-04-13 |
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CN106103480A (zh) | 2016-11-09 |
WO2015106080A3 (en) | 2015-09-11 |
SG11201605580RA (en) | 2016-10-28 |
RU2693084C2 (ru) | 2019-07-01 |
CN106103480B (zh) | 2021-10-22 |
CA2936366A1 (en) | 2015-07-16 |
ES2866935T3 (es) | 2021-10-20 |
RU2016132757A3 (es) | 2018-07-16 |
BR112016016020B1 (pt) | 2024-02-27 |
SG10201805934RA (en) | 2018-08-30 |
RU2016132757A (ru) | 2018-02-16 |
EP3092253A4 (en) | 2017-11-29 |
KR102446386B1 (ko) | 2022-09-22 |
NZ722445A (en) | 2022-07-01 |
AU2015204674B2 (en) | 2020-09-03 |
JP6882702B2 (ja) | 2021-06-02 |
US10059764B2 (en) | 2018-08-28 |
JP2020018309A (ja) | 2020-02-06 |
US20160333090A1 (en) | 2016-11-17 |
JP2017503506A (ja) | 2017-02-02 |
RU2019118984A (ru) | 2019-08-06 |
KR20160132006A (ko) | 2016-11-16 |
EP3092253B1 (en) | 2021-03-17 |
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