MX2019015150A - Composiciones antagonistas de nk-1 y métodos para su uso en el tratamiento de la depresión. - Google Patents
Composiciones antagonistas de nk-1 y métodos para su uso en el tratamiento de la depresión.Info
- Publication number
- MX2019015150A MX2019015150A MX2019015150A MX2019015150A MX2019015150A MX 2019015150 A MX2019015150 A MX 2019015150A MX 2019015150 A MX2019015150 A MX 2019015150A MX 2019015150 A MX2019015150 A MX 2019015150A MX 2019015150 A MX2019015150 A MX 2019015150A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- treating depression
- antagonist compositions
- antagonist
- treating
- Prior art date
Links
- 239000002742 neurokinin 1 receptor antagonist Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 abstract 1
- 229960003089 pramipexole Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
La presente invención describe la combinación de un antagonista de NK1 con pramipexol o una sal o solvato farmacéuticamente aceptable del mismo, útil para tratar trastornos depresivos, incluido el trastorno depresivo mayor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762527215P | 2017-06-30 | 2017-06-30 | |
PCT/US2018/039883 WO2019006050A1 (en) | 2017-06-30 | 2018-06-28 | NK-1 ANTAGONIST COMPOSITIONS AND METHODS FOR USE IN TREATING DEPRESSION |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019015150A true MX2019015150A (es) | 2020-08-13 |
Family
ID=64742221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019015150A MX2019015150A (es) | 2017-06-30 | 2018-06-28 | Composiciones antagonistas de nk-1 y métodos para su uso en el tratamiento de la depresión. |
Country Status (14)
Country | Link |
---|---|
US (3) | US11266633B2 (es) |
EP (1) | EP3645120A4 (es) |
JP (1) | JP7158425B2 (es) |
KR (1) | KR20200026920A (es) |
CN (1) | CN111032158A (es) |
AU (1) | AU2018290889A1 (es) |
BR (1) | BR112019028034A2 (es) |
CA (1) | CA3104811A1 (es) |
EA (1) | EA202090180A1 (es) |
IL (1) | IL271464B1 (es) |
MA (1) | MA49524A (es) |
MX (1) | MX2019015150A (es) |
TW (1) | TWI826380B (es) |
WO (1) | WO2019006050A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018251604B2 (en) | 2017-04-10 | 2022-04-14 | Chase Therapeutics Corporation | NK1-antagonist combination and method for treating synucleinopathies |
EP3645120A4 (en) * | 2017-06-30 | 2021-03-24 | Chase Pharmaceuticals Corporation | NK-1 ANTAGONIST COMPOSITIONS AND METHODS OF USE IN THE TREATMENT OF DEPRESSION |
US20230338355A1 (en) * | 2020-07-30 | 2023-10-26 | Acer Therapeutics Inc. | Nk antagonists for contraception |
WO2023220224A1 (en) * | 2022-05-12 | 2023-11-16 | St. Jude Children's Research Hospital, Inc. | Synergistic antifungal composition and method |
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ATE45735T1 (de) | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
KR100214905B1 (ko) | 1991-05-31 | 1999-08-02 | 디. 제이. 우드, 스피겔 알렌 제이 | 퀴누클리딘 유도체 |
US5719147A (en) | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
DE4241013A1 (de) * | 1992-12-05 | 1994-06-09 | Boehringer Ingelheim Kg | Verwendung von 2-Amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol als Arzneimittel mit antidepressiver Wirkung |
IL111002A (en) | 1993-09-22 | 1998-09-24 | Glaxo Group Ltd | History of piperidine, their preparation and the pharmaceutical preparations containing them |
TW385308B (en) | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
JP2001502311A (ja) | 1996-10-07 | 2001-02-20 | メルク シヤープ エンド ドーム リミテツド | 抗鬱及び/又は抗不安薬としてのcns浸透性nk―1受容体拮抗薬 |
ES2234039T3 (es) | 1996-12-02 | 2005-06-16 | MERCK SHARP & DOHME LTD. | Uso de antagonistas del receptor nk-1 para tratar trastornos de depresion mayor. |
US6271230B1 (en) * | 1997-12-01 | 2001-08-07 | Merck Sharp & Dohme Limited | Use of NK-1 receptor antagonists for treating cognitive disorders |
DE19830201A1 (de) | 1998-07-07 | 2000-01-13 | Boehringer Ingelheim Pharma | Mittel mit antidepressiver Wirkung |
CA2301899C (en) | 1998-07-27 | 2008-11-18 | Boehringer Ingelheim Pharma Kg | Agent with an antidepressant activity |
DK1394150T3 (da) | 1999-02-24 | 2011-03-21 | Hoffmann La Roche | 4-phenylpyridinderivater og deres anvendelse som NK-1-receptorantagonister |
GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
KR100501608B1 (ko) | 2000-07-14 | 2005-07-18 | 에프. 호프만-라 로슈 아게 | 4-페닐-피리딘 유도체의 nk1 수용체의 길항성선구약물로서의 n-산화물 |
GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
US6620438B2 (en) * | 2001-03-08 | 2003-09-16 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics and NK1-receptor antagonists |
ES2272408T3 (es) | 2000-12-14 | 2007-05-01 | F. Hoffmann-La Roche Ag | Matriz lipidica autoemulsificante (selm). |
PE20030762A1 (es) | 2001-12-18 | 2003-09-05 | Schering Corp | Compuestos heterociclicos como antagonistas nk1 |
GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
TWI341198B (en) | 2004-01-27 | 2011-05-01 | Merck Sharp & Dohme | Hydroisoindoline tachykinin receptor antagonists |
CA2554346C (en) | 2004-01-30 | 2009-11-17 | Pfizer Products Inc. | Parenteral formulations comprising a beta-cyclodextrin and a preservative |
BRPI0508254A (pt) | 2004-03-02 | 2007-07-24 | Pharmacia Corp | métodos e composições para o tratamento ou prevenção de distúrbios psiquiátricos com inibidores de cox-2 sozinhos e em combinação com agentes antidepressivos |
AU2006269383A1 (en) | 2005-07-11 | 2007-01-18 | Merck Sharp & Dohme Corp. | Process for making hydroisoindoline tachykinin receptor antagonists |
US20070225279A1 (en) | 2006-03-24 | 2007-09-27 | Wyeth | Therapeutic combinations for the treatment of depression |
EP2129381A1 (en) | 2007-01-24 | 2009-12-09 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
US20080254117A1 (en) | 2007-04-10 | 2008-10-16 | Noel Cotton | Process for preparing pramipexole dihydrochloride tablets |
GB0806652D0 (en) | 2008-04-11 | 2008-05-14 | Glaxo Group Ltd | Anhydrous crystal form of orvepitant maleate |
CN105503870A (zh) | 2009-08-14 | 2016-04-20 | 欧科生医股份有限公司 | 神经激肽-1拮抗剂的静脉内制剂 |
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EP2722045B1 (en) | 2009-11-18 | 2016-07-06 | Helsinn Healthcare SA | Compositions for treating centrally mediated nausea and vomiting |
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CN107531674B (zh) | 2015-02-11 | 2020-07-31 | 赛诺维信制药公司 | 用于治疗cns障碍的1-杂环基异苯并二氢吡喃基化合物和类似物 |
KR102623321B1 (ko) * | 2015-02-11 | 2024-01-09 | 선오비온 파마슈티컬스 인코포레이티드 | 중추 신경계 질환을 치료하기 위한 융합된 다이하이드로-4h-피라졸로[5,1-c][1,4]옥사진일 화합물 및 유사체 |
US9850267B2 (en) | 2015-06-03 | 2017-12-26 | Navinta, Llc | Crystalline fosaprepitant dicyclohexylamine salt and its preparation |
AU2016323977B9 (en) * | 2015-09-16 | 2021-03-04 | The Trustees Of Columbia University In The City Of New York | Carboxylic diarylthiazepineamines as mu-opioid receptor agonists |
US10005803B2 (en) | 2015-10-06 | 2018-06-26 | Helsinn Healthcare Sa | Crystalline forms of fosnetupitant |
NL2015865B1 (en) | 2015-11-27 | 2017-06-13 | Le Vet B V | Maropitant Formulation. |
KR102623819B1 (ko) | 2017-03-27 | 2024-01-10 | 체이스 테라퓨틱스 코포레이션 | 시누클레인병변을 치료하기 위한 조성물 및 방법 |
AU2018251604B2 (en) * | 2017-04-10 | 2022-04-14 | Chase Therapeutics Corporation | NK1-antagonist combination and method for treating synucleinopathies |
EP3645120A4 (en) * | 2017-06-30 | 2021-03-24 | Chase Pharmaceuticals Corporation | NK-1 ANTAGONIST COMPOSITIONS AND METHODS OF USE IN THE TREATMENT OF DEPRESSION |
-
2018
- 2018-06-28 EP EP18824955.1A patent/EP3645120A4/en active Pending
- 2018-06-28 JP JP2019572041A patent/JP7158425B2/ja active Active
- 2018-06-28 WO PCT/US2018/039883 patent/WO2019006050A1/en unknown
- 2018-06-28 MX MX2019015150A patent/MX2019015150A/es unknown
- 2018-06-28 IL IL271464A patent/IL271464B1/en unknown
- 2018-06-28 MA MA049524A patent/MA49524A/fr unknown
- 2018-06-28 BR BR112019028034-0A patent/BR112019028034A2/pt not_active IP Right Cessation
- 2018-06-28 AU AU2018290889A patent/AU2018290889A1/en active Pending
- 2018-06-28 EA EA202090180A patent/EA202090180A1/ru unknown
- 2018-06-28 KR KR1020207002891A patent/KR20200026920A/ko not_active Application Discontinuation
- 2018-06-28 CA CA3104811A patent/CA3104811A1/en active Pending
- 2018-06-28 US US16/612,819 patent/US11266633B2/en active Active
- 2018-06-28 CN CN201880050660.7A patent/CN111032158A/zh active Pending
- 2018-06-29 TW TW107122579A patent/TWI826380B/zh active
-
2022
- 2022-02-14 US US17/671,016 patent/US11813247B2/en active Active
- 2022-02-14 US US17/671,127 patent/US11813248B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
IL271464B1 (en) | 2024-04-01 |
US11813248B2 (en) | 2023-11-14 |
US20200147053A1 (en) | 2020-05-14 |
TW201906604A (zh) | 2019-02-16 |
AU2018290889A1 (en) | 2020-02-13 |
WO2019006050A1 (en) | 2019-01-03 |
US11266633B2 (en) | 2022-03-08 |
US20220160683A1 (en) | 2022-05-26 |
US11813247B2 (en) | 2023-11-14 |
CA3104811A1 (en) | 2019-01-03 |
EP3645120A4 (en) | 2021-03-24 |
JP7158425B2 (ja) | 2022-10-21 |
JP2020526494A (ja) | 2020-08-31 |
KR20200026920A (ko) | 2020-03-11 |
MA49524A (fr) | 2021-05-26 |
BR112019028034A2 (pt) | 2020-07-07 |
TWI826380B (zh) | 2023-12-21 |
EA202090180A1 (ru) | 2020-05-26 |
EP3645120A1 (en) | 2020-05-06 |
US20220168281A1 (en) | 2022-06-02 |
CN111032158A (zh) | 2020-04-17 |
IL271464A (en) | 2020-01-30 |
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