MX2019012945A - Formas cristalinas de un compuesto inhibidor de jak. - Google Patents

Formas cristalinas de un compuesto inhibidor de jak.

Info

Publication number
MX2019012945A
MX2019012945A MX2019012945A MX2019012945A MX2019012945A MX 2019012945 A MX2019012945 A MX 2019012945A MX 2019012945 A MX2019012945 A MX 2019012945A MX 2019012945 A MX2019012945 A MX 2019012945A MX 2019012945 A MX2019012945 A MX 2019012945A
Authority
MX
Mexico
Prior art keywords
crystalline
crystalline forms
inhibitor compound
hydrates
jak inhibitor
Prior art date
Application number
MX2019012945A
Other languages
English (en)
Inventor
Nzerem Jerry
Dabros Marta
R Thalladi Venkat
A Kleinschek Melanie
D Crater Glenn
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of MX2019012945A publication Critical patent/MX2019012945A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente invención provee hidratos cristalinos de las sales de oxalato y succinato de 5-etil-2-fluoro-4-(3-(5-(1-metilpiperidin-4 -il)-4,5,6,7-tetrahidro-1H-imidazo[4,5-c]piridin-2-il)-1Hindazol- 6-il)fenol. La invención también provee composiciones farmacéuticas que comprenden dichos hidratos cristalinos, métodos para usar dichos hidratos cristalinos para tratar enfermedades respiratorias y otras enfermedades, y procesos útiles para preparar dichos hidratos cristalinos de oxalato y succinato.
MX2019012945A 2017-05-01 2018-04-30 Formas cristalinas de un compuesto inhibidor de jak. MX2019012945A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762492571P 2017-05-01 2017-05-01
PCT/US2018/030144 WO2018204236A1 (en) 2017-05-01 2018-04-30 Crystalline forms of a jak inhibitor compound

Publications (1)

Publication Number Publication Date
MX2019012945A true MX2019012945A (es) 2019-12-16

Family

ID=62165729

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012945A MX2019012945A (es) 2017-05-01 2018-04-30 Formas cristalinas de un compuesto inhibidor de jak.

Country Status (12)

Country Link
US (1) US10251874B2 (es)
EP (1) EP3619208B1 (es)
JP (1) JP7096268B2 (es)
KR (1) KR20200003121A (es)
CN (1) CN110603255B (es)
AU (1) AU2018261591B2 (es)
CA (1) CA3059790A1 (es)
MX (1) MX2019012945A (es)
PH (1) PH12019502425A1 (es)
SG (1) SG11201909376TA (es)
TW (1) TWI808083B (es)
WO (1) WO2018204236A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108349972B (zh) 2015-11-03 2021-06-08 施万生物制药研发Ip有限责任公司 用于治疗呼吸疾病的jak激酶抑制剂化合物
AR111242A1 (es) 2017-03-09 2019-06-19 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada que contienen una amida heterocíclica de 4 miembros como inhibidores de jak
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
BR112019022665A2 (pt) 2017-05-01 2020-05-19 Theravance Biopharma R&D Ip Llc métodos de tratamento usando um composto inibidor de jak
US10844057B2 (en) 2018-09-04 2020-11-24 Theravance Biopharma R&D Ip, Llc Process for preparing JAK inhibitors and intermediates thereof
AU2019336167A1 (en) 2018-09-04 2021-03-11 Theravance Biopharma R&D Ip, Llc Dimethyl amino azetidine amides as JAK inhibitors
CN112703037B (zh) 2018-09-04 2023-10-20 施万生物制药研发Ip有限责任公司 作为jak抑制剂的5至7元杂环酰胺
SG11202103042XA (en) 2018-10-29 2021-04-29 Theravance Biopharma R&D Ip Llc 2-azabicyclo hexane compound as jak inhibitor
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
US20220306626A1 (en) * 2021-03-26 2022-09-29 Theravance Biopharma R&D Ip, Llc Crystalline form of a dihydrochloride salt of a jak inhibitor compound

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
JP4836788B2 (ja) 2003-07-23 2011-12-14 エグゼリクシス， インコーポレイテッド 未分化リンパ腫キナーゼ変調因子及びその使用法
US20050090529A1 (en) 2003-07-31 2005-04-28 Pfizer Inc 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
US7884109B2 (en) 2005-04-05 2011-02-08 Wyeth Llc Purine and imidazopyridine derivatives for immunosuppression
US8648069B2 (en) 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
JP2010111624A (ja) 2008-11-06 2010-05-20 Shionogi & Co Ltd Ｔｔｋ阻害作用を有するインダゾール誘導体
JP5651681B2 (ja) 2009-04-03 2015-01-14 大日本住友製薬株式会社 代謝型グルタミン酸受容体５介在障害の治療のための化合物、およびその使用方法
EP3305073B1 (en) 2009-12-21 2019-05-15 Samumed, LLC 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
US8575336B2 (en) * 2011-07-27 2013-11-05 Pfizer Limited Indazoles
SI3077395T1 (en) 2013-12-05 2018-03-30 Pfizer Inc. Pyrrolo (2,3-d) pyrimidinyl, pyrrolo (2,3-b) pyrazinyl and pyrrolo (2,3-d) pyridinyl acrylamides
GEP20186921B (en) 2014-05-14 2018-11-12 Pfizer Pyrazolopyridines and pyrazolopyrimidines
WO2016026078A1 (en) 2014-08-19 2016-02-25 Changzhou Jiekai Pharmatech Co., Ltd. Heterocyclic compounds as erk inhibitors
KR101663277B1 (ko) 2015-03-30 2016-10-06 주식회사 녹십자 TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물
CN108349972B (zh) 2015-11-03 2021-06-08 施万生物制药研发Ip有限责任公司 用于治疗呼吸疾病的jak激酶抑制剂化合物
PL3712152T3 (pl) 2015-11-03 2021-08-02 Topivert Pharma Limited Pochodne 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pirydyny i 1,4,5,6,7,8-heksahydroimidazo[4,5-d]azepiny jako inhibitory kinaz janusowych
EP3831830A1 (en) 2015-11-03 2021-06-09 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors

Also Published As

Publication number Publication date
AU2018261591B2 (en) 2021-09-02
EP3619208B1 (en) 2023-06-07
EP3619208A1 (en) 2020-03-11
US10251874B2 (en) 2019-04-09
CN110603255A (zh) 2019-12-20
EP3619208C0 (en) 2023-06-07
RU2019138700A3 (es) 2022-01-26
KR20200003121A (ko) 2020-01-08
SG11201909376TA (en) 2019-11-28
PH12019502425A1 (en) 2020-06-29
JP2020518582A (ja) 2020-06-25
CA3059790A1 (en) 2018-11-08
RU2019138700A (ru) 2021-06-02
CN110603255B (zh) 2023-02-10
TWI808083B (zh) 2023-07-11
JP7096268B2 (ja) 2022-07-05
US20180311223A1 (en) 2018-11-01
AU2018261591A1 (en) 2019-11-07
WO2018204236A1 (en) 2018-11-08
TW201900643A (zh) 2019-01-01

Similar Documents

Publication Publication Date Title
MX2019012945A (es) Formas cristalinas de un compuesto inhibidor de jak.
PH12019501985A1 (en) Fused imidazo-piperidine jak inhibitors
PH12016502382A1 (en) Substituted indazole compounds as irak4 inhibitors
MX2021006283A (es) Derivados heteroaromáticos para uso como regulador, método de preparación de los mismos y uso de los mismos.
TN2016000268A1 (en) N-azaspirocycloalkane substituted n-heteroaryl compounds and compositions for inhibiting the activity of shp2.
PH12019502345A1 (en) Methods of treatment using a jak inhibitor compoud
MY195427A (en) Jak Kinase Inhibitor Compounds for Treatment of Respiratory Disease
TN2017000075A1 (en) Compounds and compositions as raf kinase inhibitors
MX2016016516A (es) Inhibidores de fosfatidilinositol 3-cinasa.
MD4800C1 (ro) Compuşi de aminopirimidinil ca inhibitori de JAK
MX2016016530A (es) Inhibidores de fosfatidilinositol 3-quinasa.
PH12020551014A1 (en) Amino-fluoropiperidine derivatives as kinase inhibitor
MX2022014864A (es) Compuestos de bisamida que activan el sarcomero y sus usos.
NZ726638A (en) Phosphatidylinositol 3-kinase inhibitors
MX2023004309A (es) Inhibidores de quinasa alk2 que contienen imidazol.
NZ711424A (en) Pyridine derivatives as soft rock inhibitors
MX2016016528A (es) Inhibidores de fosfatidilinositol 3-quinasa.
EA201692266A1 (ru) Ингибиторы фосфатидилинозитол-3-киназы
SA519401322B1 (ar) مركبات أريل كربوكساميد غير متجانسة كمثطبات لكيناز بروتين سيرين/ ثريونين متداخل مع المستقبل 2
MX2020001531A (es) Nuevos compuestos hetorociclicos como inhibidores de cdk8/19.
SA519410865B1 (ar) مركب حلقي شبيه بكُومارين بوصفه مثبط mek واستخدامه
MX2016010272A (es) Derivado de indolona sustituido por pirrol, metodo de preparacion del mismo, composicion que comprende el mismo y uso del mismo.
MY195576A (en) Novel Amino-Imidazopyridine Derivatives as Janus Kinase Inhibitors and Pharmaceutical use Thereof
NZ741384A (en) Dopamine d3 receptor antagonists having a morpholine moiety
MX2016010771A (es) Compuestos que se une al receptor gamma activado por el proliferador de peroxisoma (pparg) pero que no actua como promotor y composicion farmaceutica para tratar enfermedades relacionadas con pparg que contienen el mismo como ingrediente activo.