MX2019011608A - Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. - Google Patents

Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue.

Info

Publication number
MX2019011608A
MX2019011608A MX2019011608A MX2019011608A MX2019011608A MX 2019011608 A MX2019011608 A MX 2019011608A MX 2019011608 A MX2019011608 A MX 2019011608A MX 2019011608 A MX2019011608 A MX 2019011608A MX 2019011608 A MX2019011608 A MX 2019011608A
Authority
MX
Mexico
Prior art keywords
dengue viral
compounds
indoline derivatives
viral replication
substituted indoline
Prior art date
Application number
MX2019011608A
Other languages
English (en)
Inventor
Didier M Marchand Arnaud
Rudolf Romanie Kesteleyn Bart
Jean-Marie Bernard Raboisson Pierre
Alice Marie-Eve Bardiot Dorothée
Bonfanti Jean-François
Original Assignee
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc filed Critical Janssen Pharmaceuticals Inc
Publication of MX2019011608A publication Critical patent/MX2019011608A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a derivados de indolina sustituidos, a métodos para prevenir o tratar infecciones virales por dengue mediante el uso de dichos compuestos y también se refiere a dichos compuestos para su uso como medicamento, más preferentemente, para su uso como medicamento para tratar o prevenir infecciones virales por dengue, la presente invención se refiere además a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como un medicamento, más preferentemente para la prevención o el tratamiento de infecciones virales por dengue. La invención también se refiere a procesos para la preparación de los compuestos.
MX2019011608A 2017-03-31 2018-03-29 Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. MX2019011608A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17164045 2017-03-31
PCT/EP2018/058077 WO2018178238A1 (en) 2017-03-31 2018-03-29 Substituted indoline derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number Publication Date
MX2019011608A true MX2019011608A (es) 2019-11-08

Family

ID=58464339

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011608A MX2019011608A (es) 2017-03-31 2018-03-29 Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue.

Country Status (31)

Country Link
US (1) US11179368B2 (es)
EP (1) EP3601225B1 (es)
JP (1) JP7038733B2 (es)
KR (1) KR102556222B1 (es)
CN (1) CN110612284B (es)
AR (1) AR111315A1 (es)
AU (1) AU2018246299A1 (es)
BR (1) BR112019019928A2 (es)
CA (1) CA3055260A1 (es)
CL (1) CL2019002744A1 (es)
CO (1) CO2019010292A2 (es)
CR (1) CR20190447A (es)
DK (1) DK3601225T3 (es)
EA (1) EA201992334A1 (es)
EC (1) ECSP19070413A (es)
ES (1) ES2887673T3 (es)
HR (1) HRP20211102T1 (es)
HU (1) HUE055576T2 (es)
IL (1) IL269657A (es)
JO (1) JOP20180026A1 (es)
LT (1) LT3601225T (es)
MA (1) MA48987A (es)
MX (1) MX2019011608A (es)
NI (1) NI201900098A (es)
PE (1) PE20191652A1 (es)
PH (1) PH12019502095A1 (es)
SG (1) SG11201908465QA (es)
SI (1) SI3601225T1 (es)
TW (1) TW201900610A (es)
UY (1) UY37646A (es)
WO (1) WO2018178238A1 (es)

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Also Published As

Publication number Publication date
CA3055260A1 (en) 2018-10-04
TW201900610A (zh) 2019-01-01
US11179368B2 (en) 2021-11-23
JP7038733B2 (ja) 2022-03-18
ECSP19070413A (es) 2019-10-31
NI201900098A (es) 2020-03-11
SG11201908465QA (en) 2019-10-30
KR20190135496A (ko) 2019-12-06
CN110612284B (zh) 2023-10-31
UY37646A (es) 2018-09-28
AU2018246299A1 (en) 2019-09-19
MA48987A (fr) 2020-02-05
CO2019010292A2 (es) 2019-10-09
EP3601225A1 (en) 2020-02-05
KR102556222B1 (ko) 2023-07-14
IL269657A (en) 2019-11-28
CL2019002744A1 (es) 2019-12-27
JP2020512374A (ja) 2020-04-23
CN110612284A (zh) 2019-12-24
HUE055576T2 (hu) 2021-12-28
EA201992334A1 (ru) 2020-02-20
BR112019019928A2 (pt) 2020-04-22
PE20191652A1 (es) 2019-11-07
ES2887673T3 (es) 2021-12-27
LT3601225T (lt) 2021-08-10
SI3601225T1 (sl) 2021-09-30
JOP20180026A1 (ar) 2019-01-30
WO2018178238A1 (en) 2018-10-04
PH12019502095A1 (en) 2020-03-09
US20200054606A1 (en) 2020-02-20
HRP20211102T1 (hr) 2021-10-29
DK3601225T3 (da) 2021-08-16
AR111315A1 (es) 2019-06-26
EP3601225B1 (en) 2021-06-02
CR20190447A (es) 2019-11-13

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