MX2019010338A - Administracion concomitante de moduladores de receptores de glucocorticoides e inhibidores de cyp3a. - Google Patents
Administracion concomitante de moduladores de receptores de glucocorticoides e inhibidores de cyp3a.Info
- Publication number
- MX2019010338A MX2019010338A MX2019010338A MX2019010338A MX2019010338A MX 2019010338 A MX2019010338 A MX 2019010338A MX 2019010338 A MX2019010338 A MX 2019010338A MX 2019010338 A MX2019010338 A MX 2019010338A MX 2019010338 A MX2019010338 A MX 2019010338A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- grm
- concomitant administration
- itraconazole
- ketoconazole
- Prior art date
Links
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 title abstract 8
- 208000009011 Cytochrome P-450 CYP3A Inhibitors Diseases 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 8
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 abstract 3
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 abstract 3
- 206010067484 Adverse reaction Diseases 0.000 abstract 3
- 230000006838 adverse reaction Effects 0.000 abstract 3
- 229960004130 itraconazole Drugs 0.000 abstract 3
- 229960004125 ketoconazole Drugs 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229960003248 mifepristone Drugs 0.000 abstract 2
- VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 abstract 2
- 230000010009 steroidogenesis Effects 0.000 abstract 2
- 230000001988 toxicity Effects 0.000 abstract 2
- 231100000419 toxicity Toxicity 0.000 abstract 2
- 208000014311 Cushing syndrome Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Details Of Resistors (AREA)
Abstract
El solicitante proporciona métodos para tratar enfermedades que incluyen el síndrome de Cushing y los cánceres sensibles a las hormonas mediante la administración concomitante de un modulador del receptor de glucocorticoides (GRM) y los inhibidores de esteroidogénesis, y mediante la administración concomitante de un inhibidor de GRM y CYP3A. El GRM puede ser, por ejemplo, mifepristona; los inhibidores de CYP3A o los inhibidores de esteroidogénesis (colectivamente ''inhibidores'') pueden ser, por ejemplo, ketoconazol o itraconazol. Los inhibidores pueden causar toxicidad u otras reacciones adversas graves; la administración concomitante de inhibidores con otros fármacos puede aumentar el riesgo de dicha toxicidad y reacciones adversas debido a los inhibidores y/u otros fármacos. El solicitante ha encontrado sorprendentemente que los GRM pueden administrarse a sujetos que reciben inhibidores sin aumentar el riesgo de reacciones adversas; por ejemplo, el solicitante ha descubierto que la mifepristona se puede administrar concomitantemente con ketoconazol o itraconazol, proporcionando una administración concomitante segura de GRM y ketoconazol o itraconazol. En modalidades, la dosis de GRM puede reducirse durante la administración concomitante de GRM con inhibidores.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762465772P | 2017-03-01 | 2017-03-01 | |
US201762466867P | 2017-03-03 | 2017-03-03 | |
PCT/US2018/020336 WO2018160775A1 (en) | 2017-03-01 | 2018-02-28 | Concomitant administration of glucocorticoid receptor modulators and cyp3a inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019010338A true MX2019010338A (es) | 2019-10-14 |
Family
ID=59958459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019010338A MX2019010338A (es) | 2017-03-01 | 2018-02-28 | Administracion concomitante de moduladores de receptores de glucocorticoides e inhibidores de cyp3a. |
Country Status (11)
Country | Link |
---|---|
US (6) | US20170281651A1 (es) |
EP (1) | EP3589288A4 (es) |
JP (1) | JP7218294B2 (es) |
KR (1) | KR102532583B1 (es) |
CN (1) | CN110352058A (es) |
AU (1) | AU2018229355B2 (es) |
CA (1) | CA3052668A1 (es) |
IL (1) | IL269009B2 (es) |
MX (1) | MX2019010338A (es) |
SG (1) | SG11201907854VA (es) |
WO (1) | WO2018160775A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170281651A1 (en) | 2017-03-01 | 2017-10-05 | Corcept Therapeutics, Inc. | Concomitant administration of glucocorticoid receptor modulators and cyp3a or steroidogenesis inhibitors |
KR20230016661A (ko) * | 2020-05-27 | 2023-02-02 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 글루코코르티코이드 수용체 조절제 렐라코릴란트 및 cyp2c9 기질의 병용 투여 |
JP2023527434A (ja) | 2020-05-27 | 2023-06-28 | コーセプト セラピューティクス, インコーポレイテッド | Cyp2c8及びcyp3a4の二重基質、糖質コルチコイド・レセプター・モジュレーターのリラコリラント及びパクリタキセルの併用投与 |
WO2023225282A1 (en) * | 2022-05-20 | 2023-11-23 | Corcept Therapeutics Incorporated | Methods of treating cushing's syndrome and liver disorders, and of reducing liver toxicity of other drugs administered to a patient |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001253618A1 (en) | 2000-04-21 | 2001-11-07 | Arch Development Corporation | Flavopiridol drug combinations and methods with reduced side effects |
US7163934B2 (en) | 2001-05-04 | 2007-01-16 | Corcept Therapeutics, Inc. | Methods for treating delirium glucocorticoid receptor-specific antagonists |
US20070254025A1 (en) | 2006-04-27 | 2007-11-01 | Cronk Peter J | Oral contraceptive and acne medication combination and treatment of acne with reduced side effects |
EP1886695A1 (en) | 2006-06-27 | 2008-02-13 | Speedel Experimenta AG | Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist |
US8119681B2 (en) | 2006-10-23 | 2012-02-21 | Merck Sharp & Dohme Corp. | 2-[1-phenyl-5-hydroxy or methoxy-4alpha-methyl-hexahydrocyclopenta [ƒ]indazole-5-YL]ethyl phenyl derivatives as glucocorticoid receptor ligands |
US8598149B2 (en) | 2007-08-30 | 2013-12-03 | Corcept Therapeutics, Inc. | Optimizing mifepristone levels in plasma serum of patients suffering from mental disorders treatable with glucocorticoid receptor antagonists |
EP2211845B1 (en) * | 2007-10-17 | 2017-02-22 | Laboratoire HRA Pharma | Glucocorticoid receptor antagonists such as mifepristone for treating cushing's syndrome |
ES2382618T3 (es) | 2008-03-25 | 2012-06-11 | Formac Pharmaceuticals N.V. | Método de preparación para dispersiones sólidas |
US9216221B2 (en) | 2008-11-07 | 2015-12-22 | University Of Sheffield | Medicament and method of diagnosis for treating subclinical Cushing's syndrome |
US20100135956A1 (en) | 2008-11-21 | 2010-06-03 | Auspex Pharmaceuticals, Inc. | Steroid modulators of progesterone receptor and/or glucocorticoid receptor |
PL2434891T3 (pl) | 2009-05-27 | 2020-12-28 | Ptc Therapeutics, Inc. | Sposoby leczenia nowotworu złośliwego i stanów nienowotworowych |
PE20121429A1 (es) | 2009-10-29 | 2012-11-06 | Aventis Pharma Sa | Nuevo uso antitumoral de cabazitaxel |
WO2016100838A2 (en) * | 2014-12-19 | 2016-06-23 | Alder Biopharmaceuticals, Inc. | Humanized anti-acth antibodies and use thereof |
US9943526B2 (en) | 2015-04-21 | 2018-04-17 | Corcept Therapeutics, Inc. | Optimizing mifepristone levels for cushing's patients |
CA2984623C (en) | 2015-05-18 | 2023-05-02 | Corcept Therapeutics, Inc. | Methods for diagnosing and assessing treatment for cushing's syndrome |
US20170281651A1 (en) | 2017-03-01 | 2017-10-05 | Corcept Therapeutics, Inc. | Concomitant administration of glucocorticoid receptor modulators and cyp3a or steroidogenesis inhibitors |
-
2017
- 2017-06-19 US US15/627,368 patent/US20170281651A1/en not_active Abandoned
- 2017-06-19 US US15/627,359 patent/US10195214B2/en active Active
-
2018
- 2018-02-28 WO PCT/US2018/020336 patent/WO2018160775A1/en unknown
- 2018-02-28 IL IL269009A patent/IL269009B2/en unknown
- 2018-02-28 KR KR1020197028226A patent/KR102532583B1/ko active IP Right Grant
- 2018-02-28 MX MX2019010338A patent/MX2019010338A/es unknown
- 2018-02-28 CN CN201880014847.1A patent/CN110352058A/zh active Pending
- 2018-02-28 JP JP2019547316A patent/JP7218294B2/ja active Active
- 2018-02-28 SG SG11201907854VA patent/SG11201907854VA/en unknown
- 2018-02-28 AU AU2018229355A patent/AU2018229355B2/en active Active
- 2018-02-28 US US16/482,656 patent/US20200147107A1/en not_active Abandoned
- 2018-02-28 CA CA3052668A patent/CA3052668A1/en active Pending
- 2018-02-28 EP EP18760940.9A patent/EP3589288A4/en active Pending
- 2018-12-13 US US16/219,564 patent/US10842800B2/en active Active
-
2021
- 2021-12-07 US US17/544,859 patent/US11969435B2/en active Active
-
2023
- 2023-09-01 US US18/241,364 patent/US20230414635A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3589288A4 (en) | 2020-12-30 |
WO2018160775A1 (en) | 2018-09-07 |
JP7218294B2 (ja) | 2023-02-06 |
US20220088036A1 (en) | 2022-03-24 |
US20190117676A1 (en) | 2019-04-25 |
IL269009B2 (en) | 2024-02-01 |
EP3589288A1 (en) | 2020-01-08 |
US20230414635A1 (en) | 2023-12-28 |
US10842800B2 (en) | 2020-11-24 |
AU2018229355A1 (en) | 2019-08-15 |
AU2018229355B2 (en) | 2024-02-15 |
SG11201907854VA (en) | 2019-09-27 |
CN110352058A (zh) | 2019-10-18 |
US11969435B2 (en) | 2024-04-30 |
US20170281651A1 (en) | 2017-10-05 |
IL269009A (en) | 2019-10-31 |
KR102532583B1 (ko) | 2023-05-12 |
US20170326157A1 (en) | 2017-11-16 |
JP2023052618A (ja) | 2023-04-11 |
KR20190122239A (ko) | 2019-10-29 |
CA3052668A1 (en) | 2018-09-07 |
IL269009B1 (en) | 2023-10-01 |
JP2020509032A (ja) | 2020-03-26 |
US10195214B2 (en) | 2019-02-05 |
US20200147107A1 (en) | 2020-05-14 |
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