MX2019006220A - Ligandos opioides kappa de heteroaril fenoxi benzamida. - Google Patents

Ligandos opioides kappa de heteroaril fenoxi benzamida.

Info

Publication number
MX2019006220A
MX2019006220A MX2019006220A MX2019006220A MX2019006220A MX 2019006220 A MX2019006220 A MX 2019006220A MX 2019006220 A MX2019006220 A MX 2019006220A MX 2019006220 A MX2019006220 A MX 2019006220A MX 2019006220 A MX2019006220 A MX 2019006220A
Authority
MX
Mexico
Prior art keywords
disorder
kappa opioid
heteroarylphenoxy
benzamide
preparation
Prior art date
Application number
MX2019006220A
Other languages
English (en)
Inventor
Ian Montgomery Justin
Wayne Kauffman Gregory
Antonia Rankic Danica
Aaron Brodney Michael
Nelsen Rogers Bruce
Robert Verhoest Patrick
Kashmirilal Arora Kapildev
Francis Dunn Matthew
Eric Green Michael
Mariam KABLAOUI Natasha
Richard Mente Scot
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2019006220A publication Critical patent/MX2019006220A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona compuestos de la Formula I: (ver fórmula) y sales farmaceuticamente aceptables de los mismos, en donde las variables R1, R2, R3, R4, R9, X, m y n son como se definen en la presente; procesos para la preparacion de; intermediarios utilizados en la preparacion de; y composiciones que contienen tales compuestos o sales; y sus usos para tratar trastornos asociados con opioides kappa (?-opioide) incluyendo, por ejemplo, un trastorno neurologico, o trastorno psiquiatrico tal como un trastorno neurocognitico, trastorno de abuso de sustancias, trastorno depresivo, trastorno de ansiedad, trastorno relacionado con trauma o estres y trastorno alimenticio.
MX2019006220A 2016-11-28 2017-11-27 Ligandos opioides kappa de heteroaril fenoxi benzamida. MX2019006220A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662426980P 2016-11-28 2016-11-28
US201762576435P 2017-10-24 2017-10-24
US201762585016P 2017-11-13 2017-11-13
PCT/IB2017/057418 WO2018096510A1 (en) 2016-11-28 2017-11-27 Heteroarylphenoxy benzamide kappa opioid ligands

Publications (1)

Publication Number Publication Date
MX2019006220A true MX2019006220A (es) 2019-10-07

Family

ID=60782279

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019006220A MX2019006220A (es) 2016-11-28 2017-11-27 Ligandos opioides kappa de heteroaril fenoxi benzamida.

Country Status (19)

Country Link
US (1) US10316021B2 (es)
EP (1) EP3544972B8 (es)
JP (1) JP7051853B2 (es)
CN (1) CN110234638B (es)
AU (1) AU2017365123B2 (es)
CA (1) CA3045242A1 (es)
DK (1) DK3544972T3 (es)
ES (1) ES2947293T3 (es)
FI (1) FI3544972T3 (es)
HR (1) HRP20230518T1 (es)
HU (1) HUE061945T2 (es)
IL (1) IL266962B (es)
MX (1) MX2019006220A (es)
PH (1) PH12019501172A1 (es)
PL (1) PL3544972T3 (es)
PT (1) PT3544972T (es)
RS (1) RS64258B1 (es)
TW (1) TWI720272B (es)
WO (1) WO2018096510A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018154118A2 (en) * 2017-02-24 2018-08-30 Reinmueller Viktoria Novel aromatic compounds
US11591289B2 (en) 2017-02-24 2023-02-28 Xeniopro GmbH Aromatic compounds
US11266627B1 (en) 2021-05-04 2022-03-08 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
CN111233768B (zh) * 2020-03-18 2021-08-03 徐州圣元化工有限公司 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法
AU2021253796B2 (en) * 2020-04-05 2023-06-01 Pfizer Inc. Compounds and methods for the treatment of COVID-19
WO2023170547A1 (en) * 2022-03-07 2023-09-14 Janssen Pharmaceuticals, Inc. Pure forms of crystalline aticaprant
WO2023170550A1 (en) * 2022-03-07 2023-09-14 Janssen Pharmaceuticals, Inc. Polymorph forms of aticaprant for use in treating major depressive disorder
WO2024079733A1 (en) * 2022-10-12 2024-04-18 Adama Makhteshim Ltd. Process for the preparation of aminopyridazine derivatives

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US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
WO2000017162A1 (fr) * 1998-09-21 2000-03-30 Takeda Chemical Industries, Ltd. Nouveaux derives de thiol, leur procede de production et leur utilisation
JP2000159747A (ja) 1998-09-21 2000-06-13 Takeda Chem Ind Ltd 新規チオ―ル誘導体、その製造法および用途
IT1303737B1 (it) 1998-11-11 2001-02-23 Smithkline Beecham Spa Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1.
DE60321207D1 (en) 2002-09-19 2008-07-03 Lilly Co Eli Diaryläther als opioid-rezeptor antagonisten
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EP1606275B1 (en) 2003-03-07 2008-08-27 Eli Lilly And Company Opioid receptor antagonists
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Also Published As

Publication number Publication date
AU2017365123B2 (en) 2022-02-17
CA3045242A1 (en) 2018-05-31
CN110234638B (zh) 2022-10-21
US10316021B2 (en) 2019-06-11
PL3544972T3 (pl) 2023-07-24
JP2019535799A (ja) 2019-12-12
EP3544972A1 (en) 2019-10-02
AU2017365123A1 (en) 2019-07-11
RS64258B1 (sr) 2023-07-31
HUE061945T2 (hu) 2023-09-28
CN110234638A (zh) 2019-09-13
WO2018096510A1 (en) 2018-05-31
US20180148432A1 (en) 2018-05-31
IL266962A (en) 2019-07-31
JP7051853B2 (ja) 2022-04-11
EP3544972B8 (en) 2023-06-07
EP3544972B1 (en) 2023-04-26
TW201831460A (zh) 2018-09-01
ES2947293T3 (es) 2023-08-04
HRP20230518T1 (hr) 2023-08-04
FI3544972T3 (fi) 2023-06-02
PT3544972T (pt) 2023-06-20
DK3544972T3 (da) 2023-05-30
PH12019501172A1 (en) 2019-12-11
TWI720272B (zh) 2021-03-01
IL266962B (en) 2022-02-01

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