MX2019001917A - Metodo para producir derivados de piridina 2-(3,6-dihalopyridin-2- yl)-3h-imidazol[4,5-c] y compuestos relacionados por reaccion del derivado de piridina 3h-imidazol[4,5-c] con una base organometalica de zinc-amina. - Google Patents

Metodo para producir derivados de piridina 2-(3,6-dihalopyridin-2- yl)-3h-imidazol[4,5-c] y compuestos relacionados por reaccion del derivado de piridina 3h-imidazol[4,5-c] con una base organometalica de zinc-amina.

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Publication number
MX2019001917A
MX2019001917A MX2019001917A MX2019001917A MX2019001917A MX 2019001917 A MX2019001917 A MX 2019001917A MX 2019001917 A MX2019001917 A MX 2019001917A MX 2019001917 A MX2019001917 A MX 2019001917A MX 2019001917 A MX2019001917 A MX 2019001917A
Authority
MX
Mexico
Prior art keywords
imidazol
pyridine
producing
dihalopyridin
reaction
Prior art date
Application number
MX2019001917A
Other languages
English (en)
Inventor
Fischer Rüdiger
Mosrin Marc
Wilcke David
Willot Matthieu
Kausch-Busies Nina
Hager Dominik
Hoffmeister Laura
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of MX2019001917A publication Critical patent/MX2019001917A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para preparar derivados de piridina halogenados de Fórmula (II), que se derivan de compuestos de estructura Q-H, a través de intermediarios de Fórmula (lIla) o (lllb): (ver Fórmulas). Donde: Q es un elemento estructural. (ver Fórmula). Y el símbolo # indica el enlace con el resto de la molécula, así como A, Q1, Q2, Q3, Q4, Q5 y Q6, tienen las definiciones dadas en la descripción. W es halógeno. Y es halógeno, CO2R1 o NO2, donde R1 es AlquiIo(C1-C6) o haloalquilo(C1-C6); y R2 es halógeno o -O-pivaloilo.
MX2019001917A 2016-08-16 2017-08-09 Metodo para producir derivados de piridina 2-(3,6-dihalopyridin-2- yl)-3h-imidazol[4,5-c] y compuestos relacionados por reaccion del derivado de piridina 3h-imidazol[4,5-c] con una base organometalica de zinc-amina. MX2019001917A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16184368 2016-08-16
PCT/EP2017/070184 WO2018033448A1 (de) 2016-08-16 2017-08-09 Verfahren zur herstellung von 2-(3,6-dihalopyridin-2-yl)-3h-imidazol[4,5-c]pyridinderivaten und verwandten verbindungen durch umsetzung des 3h-imidazol[4,5-c]pyridinderivats mit einer metallorganischen zink-amin base

Publications (1)

Publication Number Publication Date
MX2019001917A true MX2019001917A (es) 2019-07-15

Family

ID=56737974

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019001917A MX2019001917A (es) 2016-08-16 2017-08-09 Metodo para producir derivados de piridina 2-(3,6-dihalopyridin-2- yl)-3h-imidazol[4,5-c] y compuestos relacionados por reaccion del derivado de piridina 3h-imidazol[4,5-c] con una base organometalica de zinc-amina.

Country Status (12)

Country Link
US (1) US10875858B2 (es)
EP (1) EP3500568B1 (es)
JP (1) JP7098600B2 (es)
KR (1) KR102420235B1 (es)
CN (1) CN109819653A (es)
BR (1) BR112019003174B1 (es)
DK (1) DK3500568T3 (es)
ES (1) ES2833251T3 (es)
IL (1) IL264780B (es)
MX (1) MX2019001917A (es)
TW (1) TWI743165B (es)
WO (1) WO2018033448A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210074318A (ko) 2018-10-11 2021-06-21 바이엘 악티엔게젤샤프트 이미다졸 유도체의 제조 방법
EP3636645A1 (de) * 2018-10-11 2020-04-15 Bayer Aktiengesellschaft Verfahren zur herstellung schwefel-substituierter pyridinderivate
TWI820231B (zh) * 2018-10-11 2023-11-01 德商拜耳廠股份有限公司 用於製備經取代咪唑衍生物之方法

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CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
HUP9802822A3 (en) * 1995-08-10 1999-04-28 Bayer Ag Halobenzimidazol derivatives, intermediates, preparation thereof and microbocide compositions containing these compounds as active ingredients
PA8535601A1 (es) 2000-12-21 2002-11-28 Pfizer Derivados benzimidazol y piridilimidazol como ligandos para gabaa
JP2008512438A (ja) * 2004-09-10 2008-04-24 ファイザー・プロダクツ・インク 療法用ジフェニルエーテル系リガンド
AU2005316668B2 (en) 2004-12-13 2012-09-06 Millennium Pharmaceuticals, Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
US8030305B2 (en) * 2005-12-21 2011-10-04 Janssen Pharmaceutica N.V. Triazolopyridazines as kinase modulators
JP2013503846A (ja) 2009-09-01 2013-02-04 ファイザー・インク ベンズイミダゾール誘導体
US8754114B2 (en) * 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
BR122019003178B1 (pt) 2010-12-24 2020-04-28 Sumitomo Chemical Co método de controle de pestes
BR112015010207A2 (pt) * 2012-11-09 2017-07-11 Sumitomo Chemical Co método para promover o crescimento de plantas
ES2707305T3 (es) 2012-12-20 2019-04-03 Merck Sharp & Dohme Imidazopiridinas sustituidas como inhibidores de HDM2
WO2015002211A1 (ja) 2013-07-01 2015-01-08 住友化学株式会社 縮合複素環化合物及びその有害生物防除用途
BR112016001954A2 (pt) 2013-07-31 2017-08-01 Gilead Sciences Inc composto, composição farmacêutica, e, método para tratar uma doença ou condição
AR099677A1 (es) * 2014-03-07 2016-08-10 Sumitomo Chemical Co Compuesto heterocíclico fusionado y su uso para el control de plagas
WO2015171951A1 (en) * 2014-05-07 2015-11-12 The Regents Of The University Of Colorado, A Body Corporate 2-(4-aryl-1h-imidazol-1-yl)aniline compounds
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UY36548A (es) * 2015-02-05 2016-06-01 Bayer Cropscience Ag Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
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KR102471278B1 (ko) 2016-09-14 2022-11-25 바이엘 크롭사이언스 악티엔게젤샤프트 할로겐화 바이사이클릭 화합물의 제조 방법
CN110637019B (zh) 2017-05-02 2022-07-12 拜耳公司 作为有害物防治剂的2-(杂)芳基-取代的稠合双环杂环衍生物

Also Published As

Publication number Publication date
BR112019003174B1 (pt) 2022-10-25
IL264780B (en) 2021-09-30
US10875858B2 (en) 2020-12-29
EP3500568B1 (de) 2020-09-23
CN109819653A (zh) 2019-05-28
EP3500568A1 (de) 2019-06-26
DK3500568T3 (da) 2020-12-14
KR20190038890A (ko) 2019-04-09
JP2019524828A (ja) 2019-09-05
KR102420235B1 (ko) 2022-07-12
US20190202829A1 (en) 2019-07-04
JP7098600B2 (ja) 2022-07-11
WO2018033448A1 (de) 2018-02-22
BR112019003174A2 (pt) 2019-06-18
TWI743165B (zh) 2021-10-21
TW201819375A (zh) 2018-06-01
ES2833251T3 (es) 2021-06-14

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