MX2018013438A - Composiciones farmaceuticas para el tratamiento efectivo de cancer colorectal. - Google Patents
Composiciones farmaceuticas para el tratamiento efectivo de cancer colorectal.Info
- Publication number
- MX2018013438A MX2018013438A MX2018013438A MX2018013438A MX2018013438A MX 2018013438 A MX2018013438 A MX 2018013438A MX 2018013438 A MX2018013438 A MX 2018013438A MX 2018013438 A MX2018013438 A MX 2018013438A MX 2018013438 A MX2018013438 A MX 2018013438A
- Authority
- MX
- Mexico
- Prior art keywords
- colorectal cancer
- pharmaceutical compositions
- effective treatment
- kras4b
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
La presente invención describe composiciones farmacéuticas que comprenden el compuesto de fórmula (ver Fórmula) (compuesto C19) que inhibe específicamente la GTPasa KRAS4b mutada, por lo que resultan útiles para el tratamiento efectivo del cáncer colorectal. El compuesto C19 funciona como un estabilizador del complejo KRAS4b-PDEd, disminuyendo la proliferación de células cancerosas en cáncer colorectal, y aumentando la apoptosis a través de la disminución de la activación de la señalización oncogénica de KRAS4b.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2018013438A MX2018013438A (es) | 2018-11-01 | 2018-11-01 | Composiciones farmaceuticas para el tratamiento efectivo de cancer colorectal. |
PCT/IB2019/059380 WO2020089842A1 (en) | 2018-11-01 | 2019-11-01 | Pharmaceutical compositions for the effective treatment of colorectal cancer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2018013438A MX2018013438A (es) | 2018-11-01 | 2018-11-01 | Composiciones farmaceuticas para el tratamiento efectivo de cancer colorectal. |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018013438A true MX2018013438A (es) | 2022-07-20 |
Family
ID=70463876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018013438A MX2018013438A (es) | 2018-11-01 | 2018-11-01 | Composiciones farmaceuticas para el tratamiento efectivo de cancer colorectal. |
Country Status (2)
Country | Link |
---|---|
MX (1) | MX2018013438A (es) |
WO (1) | WO2020089842A1 (es) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015054572A1 (en) * | 2013-10-10 | 2015-04-16 | Araxes Pharma Llc | Inhibitors of kras g12c |
-
2018
- 2018-11-01 MX MX2018013438A patent/MX2018013438A/es unknown
-
2019
- 2019-11-01 WO PCT/IB2019/059380 patent/WO2020089842A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2020089842A1 (en) | 2020-05-07 |
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