MX2018013438A - Pharmaceutical compositions for the effective treatment of colorectal cancer. - Google Patents
Pharmaceutical compositions for the effective treatment of colorectal cancer.Info
- Publication number
- MX2018013438A MX2018013438A MX2018013438A MX2018013438A MX2018013438A MX 2018013438 A MX2018013438 A MX 2018013438A MX 2018013438 A MX2018013438 A MX 2018013438A MX 2018013438 A MX2018013438 A MX 2018013438A MX 2018013438 A MX2018013438 A MX 2018013438A
- Authority
- MX
- Mexico
- Prior art keywords
- colorectal cancer
- pharmaceutical compositions
- effective treatment
- kras4b
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
The present invention describes pharmaceutical compositions comprising a compound that has the formula (Compound C19), which specifically inhibits mutated GTPase KRAS4b, making the compositions useful for the effective treatment of colorectal cancer. Compound C19 acts as a stabilizer of the KRAS4b-PDE? complex, decreasing the proliferation of cancer cells in colorectal cancer, and increasing apoptosis through decreased activation of KRAS4b oncogenic signaling.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2018013438A MX2018013438A (en) | 2018-11-01 | 2018-11-01 | Pharmaceutical compositions for the effective treatment of colorectal cancer. |
PCT/IB2019/059380 WO2020089842A1 (en) | 2018-11-01 | 2019-11-01 | Pharmaceutical compositions for the effective treatment of colorectal cancer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2018013438A MX2018013438A (en) | 2018-11-01 | 2018-11-01 | Pharmaceutical compositions for the effective treatment of colorectal cancer. |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018013438A true MX2018013438A (en) | 2022-07-20 |
Family
ID=70463876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018013438A MX2018013438A (en) | 2018-11-01 | 2018-11-01 | Pharmaceutical compositions for the effective treatment of colorectal cancer. |
Country Status (2)
Country | Link |
---|---|
MX (1) | MX2018013438A (en) |
WO (1) | WO2020089842A1 (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015054572A1 (en) * | 2013-10-10 | 2015-04-16 | Araxes Pharma Llc | Inhibitors of kras g12c |
-
2018
- 2018-11-01 MX MX2018013438A patent/MX2018013438A/en unknown
-
2019
- 2019-11-01 WO PCT/IB2019/059380 patent/WO2020089842A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2020089842A1 (en) | 2020-05-07 |
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