MX2018009738A - Anticuerpos monoclonales de proteína ns1 anti-virus del dengue. - Google Patents

Anticuerpos monoclonales de proteína ns1 anti-virus del dengue.

Info

Publication number
MX2018009738A
MX2018009738A MX2018009738A MX2018009738A MX2018009738A MX 2018009738 A MX2018009738 A MX 2018009738A MX 2018009738 A MX2018009738 A MX 2018009738A MX 2018009738 A MX2018009738 A MX 2018009738A MX 2018009738 A MX2018009738 A MX 2018009738A
Authority
MX
Mexico
Prior art keywords
dengue virus
serotypes
present
sample
matched
Prior art date
Application number
MX2018009738A
Other languages
English (en)
Inventor
BOSCH Irene
Schifferli-Hamad Kimberly
MARQUEZ-GOMEZ Jose
De Puig Helena
Gehrke Lee
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of MX2018009738A publication Critical patent/MX2018009738A/es

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • G01N33/54387—Immunochromatographic test strips
    • G01N33/54388—Immunochromatographic test strips based on lateral flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invencion proporciona pares de anticuerpos coincidentes para la deteccion especifica de uno o mas de los cuatro serotipos del virus del dengue en una muestra biologica que puede contener uno o mas de tales serotipos del virus del dengue. Cada par de anticuerpos coincidentes es capaz de detectar no mas de un serotipo de la proteina NS1 del virus del dengue que puede estar presente en la muestra y no tendra reaccion cruzada con otros serotipos que puedan estar presentes en la muestra. Se pueden usar multiples pares coincidentes para detectar uno o mas serotipos del virus del dengue que pueden estar presentes en una muestra. Dichos anticuerpos de pares coincidentes facilitan el desarrollo de pruebas diagnosticas confirmatorias in vitro tales como inmunoensayos intercalados, que detectan y distinguen la presencia de uno o mas serotipos del virus del dengue en una muestra biologica, preferiblemente una muestra derivada de un sujeto humano. La invencion tambien proporciona kits que comprenden los pares de anticuerpos coincidentes de la invencion y metodos para usar los kits para inmunoensayos para la deteccion especifica de uno o mas serotipos del virus del dengue en una poblacion de pacientes. La presente invencion tambien proporciona anticuerpos monoclonales especificos para la proteina NS1 del virus del dengue y composiciones terapeuticas y metodos para tratar la infeccion por el virus del dengue.
MX2018009738A 2016-02-11 2017-02-10 Anticuerpos monoclonales de proteína ns1 anti-virus del dengue. MX2018009738A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662293990P 2016-02-11 2016-02-11
PCT/US2017/017385 WO2017139587A2 (en) 2016-02-11 2017-02-10 Anti-dengue virus ns1 protein monoclonal antibodies

Publications (1)

Publication Number Publication Date
MX2018009738A true MX2018009738A (es) 2019-02-07

Family

ID=58098711

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018009738A MX2018009738A (es) 2016-02-11 2017-02-10 Anticuerpos monoclonales de proteína ns1 anti-virus del dengue.

Country Status (6)

Country Link
US (2) US10551381B2 (es)
EP (2) EP3414265A2 (es)
BR (1) BR112018016337A2 (es)
CO (1) CO2018009434A2 (es)
MX (1) MX2018009738A (es)
WO (1) WO2017139587A2 (es)

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CN110346557B (zh) * 2019-07-15 2023-03-31 深圳海思安生物技术有限公司 一种检测试剂盒
KR102061769B1 (ko) * 2019-11-25 2020-01-02 한국세라믹기술원 금속나노입자-어피바디를 포함하는 뎅기열 바이러스 elisa 키트 및 상기 키트를 이용한 뎅기열 바이러스의 검출 방법
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Also Published As

Publication number Publication date
WO2017139587A2 (en) 2017-08-17
CO2018009434A2 (es) 2018-12-14
US20170233460A1 (en) 2017-08-17
EP3750916A3 (en) 2021-03-24
EP3414265A2 (en) 2018-12-19
BR112018016337A2 (pt) 2019-02-26
US10551381B2 (en) 2020-02-04
EP3750916A2 (en) 2020-12-16
US20200363415A1 (en) 2020-11-19
WO2017139587A3 (en) 2017-09-21
US11320433B2 (en) 2022-05-03

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