MX2018007804A - Analogos de cortistatina y usos de los mismos. - Google Patents

Analogos de cortistatina y usos de los mismos.

Info

Publication number
MX2018007804A
MX2018007804A MX2018007804A MX2018007804A MX2018007804A MX 2018007804 A MX2018007804 A MX 2018007804A MX 2018007804 A MX2018007804 A MX 2018007804A MX 2018007804 A MX2018007804 A MX 2018007804A MX 2018007804 A MX2018007804 A MX 2018007804A
Authority
MX
Mexico
Prior art keywords
human
advantageous
low
cortistatin analogs
administration
Prior art date
Application number
MX2018007804A
Other languages
English (en)
Inventor
Matthew D Shair
Efrem Pelish Henry
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of MX2018007804A publication Critical patent/MX2018007804A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

Se proporcionan derivados de Cortistatina específicos con propiedades ventajosas para la administración in vivo en un huésped, que incluye un ser humano que lo necesita; estas nuevas especies tienen una farmacocinética ventajosa, baja toxicidad, actividad de hERG de baja a moderada y/o otras propiedades farmacológicas que las hacen destacar entre la clase de Cortistatinas como candidatos superiores para administración humana.
MX2018007804A 2015-12-23 2016-12-21 Analogos de cortistatina y usos de los mismos. MX2018007804A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562387246P 2015-12-23 2015-12-23
US201662297494P 2016-02-19 2016-02-19
PCT/US2016/068125 WO2017112815A1 (en) 2015-12-23 2016-12-21 Cortistatin analogs and uses thereof

Publications (1)

Publication Number Publication Date
MX2018007804A true MX2018007804A (es) 2019-07-04

Family

ID=59091204

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018007804A MX2018007804A (es) 2015-12-23 2016-12-21 Analogos de cortistatina y usos de los mismos.

Country Status (17)

Country Link
US (1) US20180298024A1 (es)
EP (1) EP3394072A4 (es)
JP (1) JP2019508368A (es)
KR (1) KR20180095051A (es)
CN (1) CN108699085A (es)
AU (1) AU2016377678A1 (es)
BR (1) BR112018012647A2 (es)
CA (1) CA3009324A1 (es)
CL (1) CL2018001733A1 (es)
CO (1) CO2018007535A2 (es)
EA (1) EA201891511A1 (es)
IL (1) IL260123A (es)
MX (1) MX2018007804A (es)
PH (1) PH12018501351A1 (es)
RU (1) RU2018126984A (es)
SG (1) SG11201805092WA (es)
WO (1) WO2017112815A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2988601C (en) 2015-07-02 2021-12-07 F. Hoffmann-La Roche Ag Bicyclic lactams and methods of use thereof
EP3526219B1 (en) 2016-10-17 2021-12-15 F. Hoffmann-La Roche AG Bicyclic pyridone lactams and methods of use thereof
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
EP3781571B1 (en) 2018-04-20 2024-01-17 F. Hoffmann-La Roche AG N-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs)
AU2019374142A1 (en) * 2018-11-01 2021-05-27 Syros Pharmaceuticals, Inc. Methods of treating cancer in biomarker-identified patients with non-covalent inhibitors of cyclin-dependent kinase 7 (CDK7)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2723689C (en) * 2008-05-05 2016-07-05 Ryan A. Shenvi Synthesis of (+) cortistatin a and related compounds
WO2010024930A2 (en) * 2008-08-28 2010-03-04 President And Fellows Of Harvard College Cortistatin analogues and syntheses therof
US20130217014A1 (en) * 2012-02-17 2013-08-22 Genentech, Inc. Methods of using cdk8 antagonists
WO2014123900A1 (en) * 2013-02-05 2014-08-14 Sirenas Marine Discovery Anti-cancer and anti-hiv compounds
JP6494631B2 (ja) * 2013-12-24 2019-04-03 プレジデント アンド フェローズ オブ ハーバード カレッジ コルチスタチン類縁体並びにその合成及び使用

Also Published As

Publication number Publication date
JP2019508368A (ja) 2019-03-28
AU2016377678A1 (en) 2018-07-12
SG11201805092WA (en) 2018-07-30
CN108699085A (zh) 2018-10-23
US20180298024A1 (en) 2018-10-18
BR112018012647A2 (pt) 2018-12-04
KR20180095051A (ko) 2018-08-24
IL260123A (en) 2018-07-31
WO2017112815A1 (en) 2017-06-29
RU2018126984A (ru) 2020-01-23
EP3394072A4 (en) 2019-05-29
EA201891511A1 (ru) 2018-12-28
CA3009324A1 (en) 2017-06-29
PH12018501351A1 (en) 2019-02-27
EP3394072A1 (en) 2018-10-31
CL2018001733A1 (es) 2018-11-09
CO2018007535A2 (es) 2018-07-31

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