MX2018006282A - Profarmacos de un compuesto inhibidor de jak para el tratamiento de la enfermedad inflamatoria gastrointestinal. - Google Patents

Profarmacos de un compuesto inhibidor de jak para el tratamiento de la enfermedad inflamatoria gastrointestinal.

Info

Publication number
MX2018006282A
MX2018006282A MX2018006282A MX2018006282A MX2018006282A MX 2018006282 A MX2018006282 A MX 2018006282A MX 2018006282 A MX2018006282 A MX 2018006282A MX 2018006282 A MX2018006282 A MX 2018006282A MX 2018006282 A MX2018006282 A MX 2018006282A
Authority
MX
Mexico
Prior art keywords
jak inhibitor
prodrugs
treatment
inflammatory disease
gastrointestinal inflammatory
Prior art date
Application number
MX2018006282A
Other languages
English (en)
Inventor
D Long Daniel
A A Wilton Donna
Hudson Ryan
Loo Mandy
J Brassil Patrick
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of MX2018006282A publication Critical patent/MX2018006282A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms

Abstract

Compuestos que son profármacos de un agente inhibidor de JAK para la administración dirigida de un inhibidor de JAK en el tracto gastrointestinal de un mamífero. Composiciones farmacéuticas que comprenden estos compuestos. Métodos para usarlos en el tratamiento de enfermedades inflamatorias gastrointestinales. Procesos e intermediarios útiles para prepararlos.
MX2018006282A 2015-11-24 2016-11-22 Profarmacos de un compuesto inhibidor de jak para el tratamiento de la enfermedad inflamatoria gastrointestinal. MX2018006282A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562259273P 2015-11-24 2015-11-24
PCT/US2016/063254 WO2017091544A1 (en) 2015-11-24 2016-11-22 Prodrugs of a jak inhibitor compound for treatment of gastrointestinal inflammatory disease

Publications (1)

Publication Number Publication Date
MX2018006282A true MX2018006282A (es) 2019-01-21

Family

ID=57518004

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018006282A MX2018006282A (es) 2015-11-24 2016-11-22 Profarmacos de un compuesto inhibidor de jak para el tratamiento de la enfermedad inflamatoria gastrointestinal.

Country Status (32)

Country Link
US (3) US10435428B2 (es)
EP (1) EP3380486B1 (es)
JP (2) JP6778747B2 (es)
KR (1) KR20180080330A (es)
CN (1) CN108290918B (es)
AU (1) AU2016359494B2 (es)
BR (1) BR112018010650A8 (es)
CA (1) CA3003283A1 (es)
CL (1) CL2018001345A1 (es)
CO (1) CO2018005327A2 (es)
CY (1) CY1122918T1 (es)
DK (1) DK3380486T3 (es)
EA (1) EA035816B1 (es)
ES (1) ES2784523T3 (es)
HR (1) HRP20200561T1 (es)
HU (1) HUE049775T2 (es)
IL (1) IL259076B (es)
LT (1) LT3380486T (es)
ME (1) ME03757B (es)
MX (1) MX2018006282A (es)
MY (1) MY189979A (es)
NZ (1) NZ742574A (es)
PH (1) PH12018501037A1 (es)
PL (1) PL3380486T3 (es)
PT (1) PT3380486T (es)
RS (1) RS60237B1 (es)
SG (1) SG11201803686UA (es)
SI (1) SI3380486T1 (es)
TW (1) TWI703147B (es)
UA (1) UA121270C2 (es)
WO (1) WO2017091544A1 (es)
ZA (1) ZA201802967B (es)

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CA3159348A1 (en) 2019-11-08 2021-05-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
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EP4149462A4 (en) 2020-05-14 2024-04-24 Theravance Biopharma R&D Ip Llc ADMINISTRATION OF A GUT SELECTIVE JAK3 INHIBITOR
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Publication number Publication date
US11608354B2 (en) 2023-03-21
EP3380486B1 (en) 2020-02-19
US20190389895A1 (en) 2019-12-26
ES2784523T3 (es) 2020-09-28
HUE049775T2 (hu) 2020-10-28
EA201891248A1 (ru) 2018-10-31
US20170145044A1 (en) 2017-05-25
PH12018501037A1 (en) 2019-01-28
JP2020196742A (ja) 2020-12-10
AU2016359494B2 (en) 2021-01-07
JP6778747B2 (ja) 2020-11-04
HRP20200561T1 (hr) 2020-06-26
EP3380486A1 (en) 2018-10-03
IL259076A (en) 2018-06-28
RS60237B1 (sr) 2020-06-30
UA121270C2 (uk) 2020-04-27
CN108290918B (zh) 2021-06-08
AU2016359494A1 (en) 2018-06-14
IL259076B (en) 2021-05-31
PT3380486T (pt) 2020-05-22
ME03757B (me) 2021-04-20
BR112018010650A8 (pt) 2019-02-26
SI3380486T1 (sl) 2020-07-31
TW201720827A (zh) 2017-06-16
DK3380486T3 (da) 2020-05-18
CA3003283A1 (en) 2017-06-01
US10435428B2 (en) 2019-10-08
CO2018005327A2 (es) 2018-05-31
TWI703147B (zh) 2020-09-01
WO2017091544A1 (en) 2017-06-01
CN108290918A (zh) 2018-07-17
CY1122918T1 (el) 2021-10-29
PL3380486T3 (pl) 2020-07-27
SG11201803686UA (en) 2018-06-28
BR112018010650A2 (pt) 2018-11-13
CL2018001345A1 (es) 2018-06-22
ZA201802967B (en) 2019-04-24
LT3380486T (lt) 2020-05-11
US20210179655A1 (en) 2021-06-17
KR20180080330A (ko) 2018-07-11
EA035816B1 (ru) 2020-08-14
JP2019501133A (ja) 2019-01-17
MY189979A (en) 2022-03-22
NZ742574A (en) 2018-11-30
US10961267B2 (en) 2021-03-30

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