MX2018004220A - Tetrahidropiranilsulfonas sustituidas con pirazolilo. - Google Patents
Tetrahidropiranilsulfonas sustituidas con pirazolilo.Info
- Publication number
- MX2018004220A MX2018004220A MX2018004220A MX2018004220A MX2018004220A MX 2018004220 A MX2018004220 A MX 2018004220A MX 2018004220 A MX2018004220 A MX 2018004220A MX 2018004220 A MX2018004220 A MX 2018004220A MX 2018004220 A MX2018004220 A MX 2018004220A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrazolyl substituted
- tetrahydropyranylsulfones
- compounds
- substituted tetrahydropyranylsulfones
- pyrazolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
La invención se refiere a tetrahidropiranilsulfonas sustituidas con pirazolilo como bloqueadores de los canales de calcio dependientes de voltaje, a composiciones farmacéuticas que contienen estos compuestos y también a estos compuestos para utilizar en el tratamiento y/o profilaxis del dolor y de otras enfermedades y/o trastornos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15002879 | 2015-10-08 | ||
PCT/EP2016/025107 WO2017059965A1 (en) | 2015-10-08 | 2016-10-07 | Pyrazolyl substituted tetrahydropyranylsulfones |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018004220A true MX2018004220A (es) | 2018-11-09 |
Family
ID=54293014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018004220A MX2018004220A (es) | 2015-10-08 | 2016-10-07 | Tetrahidropiranilsulfonas sustituidas con pirazolilo. |
Country Status (12)
Country | Link |
---|---|
US (1) | US10106530B2 (es) |
EP (2) | EP3617203A1 (es) |
JP (1) | JP2018530567A (es) |
CN (1) | CN108368092A (es) |
AR (1) | AR106296A1 (es) |
AU (1) | AU2016336776A1 (es) |
BR (1) | BR112018007006A2 (es) |
CA (1) | CA3001044A1 (es) |
HK (1) | HK1258456A1 (es) |
MX (1) | MX2018004220A (es) |
TW (1) | TW201718557A (es) |
WO (1) | WO2017059965A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3470406A1 (en) | 2014-04-14 | 2019-04-17 | Grünenthal GmbH | Aryl substituted heterocyclyl sulfones |
JP6673850B2 (ja) | 2014-04-14 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ヘテロアリール置換されたヘテロシクリルスルホン |
TW201726128A (zh) | 2015-10-08 | 2017-08-01 | 歌林達有限公司 | 經吡唑基取代之四氫哌喃基碸 |
MX2020001352A (es) | 2017-08-09 | 2020-03-20 | Denali Therapeutics Inc | Compuestos, composiciones y metodos. |
SI3676297T1 (sl) * | 2017-09-01 | 2023-12-29 | Denali Therapeutics Inc. | Spojine, sestavki in postopki |
CR20210426A (es) | 2019-02-13 | 2021-09-30 | Denali Therapeutics Inc | Compuestos, composiciones y métodos |
WO2021038586A1 (en) * | 2019-08-29 | 2021-03-04 | Keminntek Laboratories | Improved process for the preparation of tezacaftor intermediate |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006522130A (ja) * | 2003-04-03 | 2006-09-28 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャンネル遮断薬としてのビアリール置換ピラゾール |
CA2633653A1 (en) * | 2005-12-21 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
WO2007125398A2 (en) | 2006-04-27 | 2007-11-08 | Pfizer Japan Inc. | : sulfonamide compounds as antagonists of the n-type calcium channel |
EP2158183A2 (en) * | 2007-05-25 | 2010-03-03 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
EP2477963A4 (en) | 2009-09-18 | 2013-02-27 | Zalicus Pharmaceuticals Ltd | ARYLSULFON DERIVATIVES AS CALCIUM CHANNEL BLOCKERS |
EP2885293B1 (en) * | 2012-08-16 | 2016-07-27 | Janssen Pharmaceutica, N.V. | Substituted pyrazoles as n-type calcium channel blockers |
BR112015003393A2 (pt) * | 2012-08-16 | 2017-07-04 | Janssen Pharmaceutica Nv | pirazóis substituídos como bloqueadores de canal de cálcio de tipo-n |
TW201416348A (zh) * | 2012-08-29 | 2014-05-01 | Gruenenthal Chemie | 以氟甲基取代之吡咯甲醯胺 |
EP3470406A1 (en) * | 2014-04-14 | 2019-04-17 | Grünenthal GmbH | Aryl substituted heterocyclyl sulfones |
JP6673850B2 (ja) * | 2014-04-14 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ヘテロアリール置換されたヘテロシクリルスルホン |
TW201726128A (zh) | 2015-10-08 | 2017-08-01 | 歌林達有限公司 | 經吡唑基取代之四氫哌喃基碸 |
-
2016
- 2016-10-06 TW TW105132385A patent/TW201718557A/zh unknown
- 2016-10-07 US US15/287,947 patent/US10106530B2/en not_active Expired - Fee Related
- 2016-10-07 CA CA3001044A patent/CA3001044A1/en not_active Abandoned
- 2016-10-07 JP JP2018517883A patent/JP2018530567A/ja not_active Withdrawn
- 2016-10-07 AU AU2016336776A patent/AU2016336776A1/en not_active Abandoned
- 2016-10-07 EP EP19198302.2A patent/EP3617203A1/en not_active Withdrawn
- 2016-10-07 BR BR112018007006A patent/BR112018007006A2/pt not_active Application Discontinuation
- 2016-10-07 EP EP16781291.6A patent/EP3359534A1/en not_active Withdrawn
- 2016-10-07 WO PCT/EP2016/025107 patent/WO2017059965A1/en active Application Filing
- 2016-10-07 CN CN201680057963.2A patent/CN108368092A/zh active Pending
- 2016-10-07 MX MX2018004220A patent/MX2018004220A/es unknown
- 2016-10-07 AR ARP160103077A patent/AR106296A1/es unknown
-
2019
- 2019-01-16 HK HK19100761.6A patent/HK1258456A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US10106530B2 (en) | 2018-10-23 |
BR112018007006A2 (pt) | 2018-10-16 |
CA3001044A1 (en) | 2017-04-13 |
EP3359534A1 (en) | 2018-08-15 |
HK1258456A1 (zh) | 2019-11-15 |
WO2017059965A1 (en) | 2017-04-13 |
US20170101397A1 (en) | 2017-04-13 |
AU2016336776A1 (en) | 2018-05-24 |
AR106296A1 (es) | 2018-01-03 |
EP3617203A1 (en) | 2020-03-04 |
CN108368092A (zh) | 2018-08-03 |
JP2018530567A (ja) | 2018-10-18 |
TW201718557A (zh) | 2017-06-01 |
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