MX2018003389A - Fitasas modificadas y metodos de uso. - Google Patents

Fitasas modificadas y metodos de uso.

Info

Publication number
MX2018003389A
MX2018003389A MX2018003389A MX2018003389A MX2018003389A MX 2018003389 A MX2018003389 A MX 2018003389A MX 2018003389 A MX2018003389 A MX 2018003389A MX 2018003389 A MX2018003389 A MX 2018003389A MX 2018003389 A MX2018003389 A MX 2018003389A
Authority
MX
Mexico
Prior art keywords
phytases
engineered
methods
target
same
Prior art date
Application number
MX2018003389A
Other languages
English (en)
Inventor
Shen Binzhang
Lazar Gabor
Michael Raab R
Original Assignee
Agrivida Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agrivida Inc filed Critical Agrivida Inc
Publication of MX2018003389A publication Critical patent/MX2018003389A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/14—Pretreatment of feeding-stuffs with enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Physiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se proporcionan métodos para mejorar la estabilidad térmica de la fitasa mediante la fusión de elementos de unión a las fitasas objetivo. Se describen fitasas diseñadas que incluyen elementos de unión fusionados a las fitasas objetivo para provocar la ciclación de las fitasas diseñadas y mejorar la estabilidad térmica de las fitasas objetivo. También se proporcionan ácidos nucleicos modificados que codifican fitasas y hospedadores diseñados por ingeniería genética para expresar ácidos nucleicos diseñados. Se describen métodos para incorporar fitasas artificiales en alimentos para animales y alimentos para animales que incluyen los mismos.
MX2018003389A 2015-09-18 2016-09-16 Fitasas modificadas y metodos de uso. MX2018003389A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562220688P 2015-09-18 2015-09-18
PCT/US2016/052147 WO2017049094A1 (en) 2015-09-18 2016-09-16 Engineered phytases and methods of using the same

Publications (1)

Publication Number Publication Date
MX2018003389A true MX2018003389A (es) 2019-09-18

Family

ID=58289629

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018003389A MX2018003389A (es) 2015-09-18 2016-09-16 Fitasas modificadas y metodos de uso.
MX2021004102A MX2021004102A (es) 2015-09-18 2018-03-16 Fitasas modificadas y metodos de uso.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021004102A MX2021004102A (es) 2015-09-18 2018-03-16 Fitasas modificadas y metodos de uso.

Country Status (10)

Country Link
US (3) US10687542B2 (es)
EP (1) EP3350201B1 (es)
CN (1) CN108026145B (es)
AU (1) AU2016323780B2 (es)
CA (1) CA2996313A1 (es)
CL (1) CL2018000708A1 (es)
DK (1) DK3350201T3 (es)
HK (1) HK1254830A1 (es)
MX (2) MX2018003389A (es)
WO (1) WO2017049094A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201509882WA (en) 2013-06-04 2016-01-28 Tribiotica Llc Methods and compositions for templated assembly of nucleic acid specific heterocompounds
CN107208313B (zh) 2014-12-02 2022-01-07 特里比奥迪卡有限责任公司 用于治疗诊断应用的方法和试剂盒
CN108026145B (zh) * 2015-09-18 2022-06-10 谷万达公司 工程化植酸酶及其使用方法
WO2018094070A1 (en) 2016-11-21 2018-05-24 Tribiotica Llc Methods for preventing titration of bimolecular templated assembly reactions by structurally-determined differential hybridizations
JP2019535281A (ja) 2016-11-21 2019-12-12 トリビオティカ・エルエルシー 鋳型化アセンブリ反応による、タンパク質の指向性折り畳みアセンブリまたは二量体化のための方法
GB201706430D0 (en) * 2017-04-24 2017-06-07 Univ Oxford Innovation Ltd Proteins and peptide tags with enhanced rate of spontaneous isopeptide bond formation and uses thereof
CA3072569A1 (en) * 2017-08-11 2019-02-14 Tribiotica Llc Methods for generating epitopes for binding to recognition molecules by templated assembly
WO2019209623A1 (en) * 2018-04-26 2019-10-31 Danisco Us Inc Method for increasing stability of phytase in a solid composition and a granule composition comprising phosphate and phytase
CN110872585B (zh) * 2018-08-29 2021-10-19 北京科技大学 用SpyTag/SpyCatcher环化的L-β-羟基-α-氨基酸合成酶及其用途
WO2020190323A1 (en) * 2019-03-21 2020-09-24 Fornia Biosolutions, Inc. Additional phytase variants and methods
CN110846336B (zh) * 2019-11-26 2022-12-20 温氏食品集团股份有限公司 一种多功能融合酶xaet和多功能融合酶定点整合真核特异表达载体及其构建方法
EP4119660A1 (en) * 2021-07-16 2023-01-18 AB Enzymes Oy Phytase variants
EP4119661A1 (en) * 2021-07-16 2023-01-18 AB Enzymes Oy Phytase variants with improved stability and ip4 activity
CN113832126A (zh) * 2021-11-27 2021-12-24 中国农业科学院北京畜牧兽医研究所 一种提高植酸酶热稳定性的方法及融合植酸酶
CN114672505A (zh) * 2022-03-15 2022-06-28 江苏省中国科学院植物研究所 一种功能性表达细胞色素p450酶的方法及其应用
CN115093470B (zh) * 2022-06-30 2023-03-24 广州市乾相生物科技有限公司 内含肽Mtu RecA突变体及其在生产谷胱甘肽GSH中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3754936B2 (ja) * 2001-07-10 2006-03-15 キヤノン株式会社 ポリヒドロキシアルカノエート含有構造体およびその製造方法
CA2805007C (en) 2002-01-08 2015-09-08 Agrivida, Inc. Transgenic plants expressing civps or intein modified proteins and related method
US7872096B2 (en) * 2004-05-24 2011-01-18 Rigel Pharmaceuticals, Inc. Methods for cyclizing synthetic polymers
US7629139B2 (en) 2005-06-21 2009-12-08 Ab Enzymes Gmbh Extraction methods and assays for feed enzymes
WO2008143679A2 (en) * 2006-06-01 2008-11-27 Verenium Corporation Nucleic acids and proteins and methods for making and using them
EP2617819B1 (en) * 2006-09-21 2016-04-27 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
WO2009073399A2 (en) * 2007-12-03 2009-06-11 Syngenta Participations Ag Engineering enzymatically susceptible proteins
CN101638642B (zh) * 2008-08-01 2012-02-22 中国农业科学院生物技术研究所 提高了热稳定性及蛋白酶抗性的环化植酸酶
MX336638B (es) * 2009-10-22 2016-01-26 Basf Se Variantes sinteticas de fitasa.
US8420387B2 (en) * 2009-11-06 2013-04-16 Agrivida, Inc. Intein-modified enzymes, their production and industrial applications
US9464333B2 (en) * 2009-11-06 2016-10-11 Agrivida, Inc. Intein-modified enzymes, their production and industrial applications
US10407742B2 (en) * 2009-11-06 2019-09-10 Agrivida, Inc. Intein-modified enzymes, their production and industrial applications
US20120190609A1 (en) * 2010-08-30 2012-07-26 Martin Bader Method for producing a lipid particle, the lipid particle itself and its use
US20150037491A1 (en) * 2012-02-07 2015-02-05 Danisco Us Inc. Phytic Acid as a Stabilizer for Phytase
RU2014137621A (ru) * 2012-02-29 2016-04-20 Ф.Хоффманн-Ля Рош Аг Способ уменьшения 1->2 сдвига рамки считывания
CN108026145B (zh) * 2015-09-18 2022-06-10 谷万达公司 工程化植酸酶及其使用方法

Also Published As

Publication number Publication date
MX2021004102A (es) 2021-06-08
CN108026145B (zh) 2022-06-10
EP3350201A4 (en) 2019-05-08
BR112018005287A2 (pt) 2018-12-11
US11241025B2 (en) 2022-02-08
AU2016323780B2 (en) 2021-11-11
US11805792B2 (en) 2023-11-07
AU2016323780A1 (en) 2018-03-08
US20180255804A1 (en) 2018-09-13
US10687542B2 (en) 2020-06-23
CL2018000708A1 (es) 2018-12-07
EP3350201B1 (en) 2022-02-16
US20220095647A1 (en) 2022-03-31
CA2996313A1 (en) 2017-03-23
HK1254830A1 (zh) 2019-07-26
DK3350201T3 (da) 2022-03-07
EP3350201A1 (en) 2018-07-25
US20200275679A1 (en) 2020-09-03
CN108026145A (zh) 2018-05-11
WO2017049094A1 (en) 2017-03-23

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