MX2017009537A - Conjugados ureasa-anticuerpo con fines terapeuticos. - Google Patents
Conjugados ureasa-anticuerpo con fines terapeuticos.Info
- Publication number
- MX2017009537A MX2017009537A MX2017009537A MX2017009537A MX2017009537A MX 2017009537 A MX2017009537 A MX 2017009537A MX 2017009537 A MX2017009537 A MX 2017009537A MX 2017009537 A MX2017009537 A MX 2017009537A MX 2017009537 A MX2017009537 A MX 2017009537A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody
- urease
- therapeutic purposes
- conjugates
- urease conjugates
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 108010046334 Urease Proteins 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 238000011097 chromatography purification Methods 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6815—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6853—Carcino-embryonic antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6857—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from lung cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Se describen composiciones farmacéuticas que comprenden conjugados ureasa-anticuerpo, y sustancialmente libres de ureasa no conjugada. Estas composiciones se preparan mediante un método que no requiere purificación cromatográfica. Estas composiciones farmacéuticas tienen utilidad en el tratamiento contra el cáncer mediante un tratamiento con profármaco de enzima con especificidad de objetivo al anticuerpo en donde la ureasa convierte in situ a la urea endógena en amoniaco para inducir citotoxicidad.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562107210P | 2015-01-23 | 2015-01-23 | |
PCT/IB2016/050342 WO2016116907A1 (en) | 2015-01-23 | 2016-01-22 | Antibody-urease conjugates for therapeutic purposes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017009537A true MX2017009537A (es) | 2018-04-10 |
Family
ID=56416507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017009537A MX2017009537A (es) | 2015-01-23 | 2016-01-22 | Conjugados ureasa-anticuerpo con fines terapeuticos. |
Country Status (18)
Country | Link |
---|---|
US (1) | US11931422B2 (es) |
EP (1) | EP3261678B8 (es) |
JP (2) | JP6876618B2 (es) |
KR (1) | KR102318994B1 (es) |
CN (1) | CN107206103A (es) |
AU (1) | AU2016210551B2 (es) |
BR (1) | BR112017015582A2 (es) |
CA (1) | CA2973538C (es) |
ES (1) | ES2852001T3 (es) |
IL (1) | IL253549B (es) |
MX (1) | MX2017009537A (es) |
NZ (1) | NZ733669A (es) |
PL (1) | PL238187B1 (es) |
RU (1) | RU2689689C2 (es) |
SG (1) | SG11201705982PA (es) |
UA (1) | UA121881C2 (es) |
WO (1) | WO2016116907A1 (es) |
ZA (1) | ZA201704709B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102318994B1 (ko) | 2015-01-23 | 2021-10-29 | 헬릭스 바이오파마 코포레이션 | 치료학적 목적을 위한 항체-우레아제 접합체 |
CN110022891A (zh) * | 2016-09-24 | 2019-07-16 | 赫利克斯生物药品公司 | 恢复肿瘤酸化t细胞的功能 |
WO2018126316A1 (en) * | 2017-01-05 | 2018-07-12 | Helix Biopharma Corporation | Vegfr-2 antibodies |
CN110382551A (zh) * | 2017-01-05 | 2019-10-25 | 赫利克斯生物药品公司 | 抗vegfr-2脲酶缀合物 |
JP6899560B2 (ja) * | 2017-05-23 | 2021-07-07 | 株式会社島津製作所 | 質量分析データ解析装置及び質量分析データ解析用プログラム |
CA3102398A1 (en) | 2018-06-03 | 2019-12-12 | Lamkap Bio Beta Ltd. | Bispecific antibodies against ceacam5 and cd47 |
PE20221045A1 (es) | 2019-09-18 | 2022-06-22 | Lamkap Bio Alpha AG | Anticuerpos biespecificos contra ceacam5 y cd3 |
EP3831849A1 (en) | 2019-12-02 | 2021-06-09 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
Family Cites Families (32)
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US4329332A (en) | 1978-07-19 | 1982-05-11 | Patrick Couvreur | Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them |
US4489055A (en) | 1978-07-19 | 1984-12-18 | N.V. Sopar S.A. | Process for preparing biodegradable submicroscopic particles containing a biologically active substance and their use |
FR2504408B1 (fr) | 1981-04-24 | 1986-02-14 | Couvreur Patrick | Procede de preparation de particules submicroscopiques, particules ainsi obtenues et compositions pharmaceutiques les contenant |
FR2523445A1 (fr) | 1982-03-17 | 1983-09-23 | Sanofi Sa | Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues |
US4867962A (en) | 1988-02-26 | 1989-09-19 | Neorx Corporation | Functionally specific antibodies |
FR2637612B1 (fr) | 1988-10-06 | 1993-09-10 | Pasteur Institut | Sequences de nucleotides codant pour une proteine a activite ureasique |
IE62496B1 (en) * | 1990-04-19 | 1995-02-08 | Res Dev Foundation | Antibody conjugates for treatment of neoplastic disease |
US5298399A (en) | 1990-08-10 | 1994-03-29 | Sapporo Breweries Limited | Gene and process for producing a thermostable urease |
FR2683159B1 (fr) | 1991-10-31 | 1994-02-25 | Coletica | Procede de fabrication de nanocapsules a paroi a base de proteines reticulees; nanocapsules ainsi obtenues et compositions cosmetiques, pharmaceutiques et alimentaires en comportant application. |
US5976535A (en) | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
GB9300875D0 (en) | 1993-01-18 | 1993-03-10 | Ucb Sa | Nanocapsule containing pharmaceutical compositions |
CA2151742C (en) | 1993-02-22 | 1999-05-25 | Alfred A. Amkraut | Compositions for oral delivery of active agents |
JPH08509873A (ja) | 1993-05-19 | 1996-10-22 | アンスティテュ・パストゥール | ヘリコバクター感染に対する免疫組成物、該組成物に用いられるポリペプチドおよび該ポリペプチドをコードする核酸配列 |
CA2130072C (en) * | 1994-08-12 | 2003-02-18 | John W. Cherwonogrodzky | Method of detecting a pathogen using a virus |
WO1997015316A1 (en) * | 1995-10-27 | 1997-05-01 | Merck & Co., Inc. | Conjugates of gonadotropin releasing hormone |
EP0824019B1 (en) * | 1996-08-13 | 2002-11-20 | Quest International B.V. | Inhibition or reduction of oral malodour |
EP0932390A1 (en) | 1996-10-11 | 1999-08-04 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method |
US6261537B1 (en) | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
US6180114B1 (en) | 1996-11-21 | 2001-01-30 | University Of Washington | Therapeutic delivery using compounds self-assembled into high axial ratio microstructures |
FR2790405B1 (fr) | 1999-03-02 | 2001-04-20 | Oreal | Nanocapsules a base de polymeres dendritiques |
WO2001037721A2 (en) | 1999-11-22 | 2001-05-31 | The Research Foundation Of State University Of New York | Magnetic nanoparticles for selective therapy |
RU2326691C2 (ru) * | 2002-07-18 | 2008-06-20 | Хеликс Биофарма Корп. | Использование уреазы для ингибирования роста раковых клеток |
JP5618453B2 (ja) * | 2003-11-28 | 2014-11-05 | ナショナル リサーチ カウンシル オブ カナダ | 抗癌抗体およびその使用 |
ATE493152T1 (de) | 2004-09-23 | 2011-01-15 | Guerbet Sa | Liposomale kontrastmittel für die cest-bildgebung |
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US20140051839A1 (en) | 2010-11-16 | 2014-02-20 | Octapharma Ag | Process for Reduction and/or Removal of FXI and FXIa from Solutions Containing said Coagulation Factors |
BR112013019150A2 (pt) | 2011-01-28 | 2019-09-24 | Nat Res Council Canada | engenharia do âmbito da imunoglobulina |
US9296819B2 (en) * | 2012-06-12 | 2016-03-29 | Promis Neurosciences Inc. | Antibodies and conjugates that target misfolded prion protein |
EP2984170A4 (en) * | 2013-04-08 | 2016-11-30 | Helix Biopharma Corp | USE OF ANTIBODY UREASE CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
KR102318994B1 (ko) | 2015-01-23 | 2021-10-29 | 헬릭스 바이오파마 코포레이션 | 치료학적 목적을 위한 항체-우레아제 접합체 |
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2016
- 2016-01-22 KR KR1020177023319A patent/KR102318994B1/ko active IP Right Grant
- 2016-01-22 CN CN201680010487.9A patent/CN107206103A/zh active Pending
- 2016-01-22 SG SG11201705982PA patent/SG11201705982PA/en unknown
- 2016-01-22 BR BR112017015582A patent/BR112017015582A2/pt not_active IP Right Cessation
- 2016-01-22 EP EP16739870.0A patent/EP3261678B8/en active Active
- 2016-01-22 MX MX2017009537A patent/MX2017009537A/es unknown
- 2016-01-22 PL PL423259A patent/PL238187B1/pl unknown
- 2016-01-22 RU RU2017129729A patent/RU2689689C2/ru active
- 2016-01-22 JP JP2017557508A patent/JP6876618B2/ja active Active
- 2016-01-22 NZ NZ733669A patent/NZ733669A/en not_active IP Right Cessation
- 2016-01-22 AU AU2016210551A patent/AU2016210551B2/en not_active Ceased
- 2016-01-22 US US15/545,549 patent/US11931422B2/en active Active
- 2016-01-22 CA CA2973538A patent/CA2973538C/en active Active
- 2016-01-22 ES ES16739870T patent/ES2852001T3/es active Active
- 2016-01-22 WO PCT/IB2016/050342 patent/WO2016116907A1/en active Application Filing
- 2016-01-22 UA UAA201708582A patent/UA121881C2/uk unknown
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2017
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- 2017-07-18 IL IL253549A patent/IL253549B/en unknown
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SG11201705982PA (en) | 2017-08-30 |
JP6876618B2 (ja) | 2021-06-02 |
KR102318994B1 (ko) | 2021-10-29 |
IL253549A (en) | 2019-08-29 |
CA2973538C (en) | 2021-01-12 |
KR20170131365A (ko) | 2017-11-29 |
EP3261678A1 (en) | 2018-01-03 |
RU2017129729A (ru) | 2019-02-25 |
US20180000963A1 (en) | 2018-01-04 |
ES2852001T3 (es) | 2021-09-10 |
CA2973538A1 (en) | 2016-07-28 |
US11931422B2 (en) | 2024-03-19 |
CN107206103A (zh) | 2017-09-26 |
EP3261678B1 (en) | 2020-11-11 |
RU2689689C2 (ru) | 2019-05-28 |
AU2016210551A1 (en) | 2017-07-27 |
PL238187B1 (pl) | 2021-07-19 |
IL253549B (en) | 2021-07-29 |
NZ733669A (en) | 2019-03-29 |
ZA201704709B (en) | 2019-11-27 |
EP3261678B8 (en) | 2021-03-17 |
WO2016116907A1 (en) | 2016-07-28 |
JP2020143084A (ja) | 2020-09-10 |
PL423259A1 (pl) | 2018-03-26 |
UA121881C2 (uk) | 2020-08-10 |
EP3261678A4 (en) | 2018-12-05 |
AU2016210551B2 (en) | 2019-03-07 |
RU2017129729A3 (es) | 2019-02-25 |
JP2018506581A (ja) | 2018-03-08 |
BR112017015582A2 (pt) | 2018-03-13 |
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