MX2017009408A - Compuestos antihelminticos, composiciones y metodo para usar los mismos. - Google Patents
Compuestos antihelminticos, composiciones y metodo para usar los mismos.Info
- Publication number
- MX2017009408A MX2017009408A MX2017009408A MX2017009408A MX2017009408A MX 2017009408 A MX2017009408 A MX 2017009408A MX 2017009408 A MX2017009408 A MX 2017009408A MX 2017009408 A MX2017009408 A MX 2017009408A MX 2017009408 A MX2017009408 A MX 2017009408A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- compositions
- ring
- anthelmintic compounds
- alkoxyalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
La presente invención se relaciona a compuestos antihelmínticos novedosos de la fórmula (IA) enseguida: en donde, Y se selecciona del grupo que consiste de -H, arilo, cicloalquilo, cicloalquenilo, heteroarilo, heterociclilo, alquilo, haloalquilo y alcoxialquilo; y Z se selecciona del grupo que consiste de arilo, cicloalquilo, cicloalquenilo, heteroarilo, heterociclilo, alquilo, haloalquilo y alcoxialquilo. Las variables Anillo A, Anillo B, Anillo C, X1, X6 y X8 son como se definen en la presente. La invención también se relaciona a composiciones parasiticidas que comprenden los compuestos, y métodos y usos de los compuestos para tratar y prevenir infecciones e infestaciones parasíticas en animales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562105463P | 2015-01-20 | 2015-01-20 | |
PCT/US2016/014148 WO2016118638A1 (en) | 2015-01-20 | 2016-01-20 | Anthelmintic compounds, compositions and method of using thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017009408A true MX2017009408A (es) | 2017-10-02 |
Family
ID=55299781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017009408A MX2017009408A (es) | 2015-01-20 | 2016-01-20 | Compuestos antihelminticos, composiciones y metodo para usar los mismos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US10597364B2 (es) |
EP (1) | EP3247701B1 (es) |
JP (1) | JP6771469B2 (es) |
CN (1) | CN107257793A (es) |
AU (3) | AU2016209321B2 (es) |
BR (1) | BR112017015273A2 (es) |
CA (1) | CA2973873A1 (es) |
ES (1) | ES2907461T3 (es) |
MX (1) | MX2017009408A (es) |
NZ (1) | NZ734082A (es) |
WO (1) | WO2016118638A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
BR112018075734A2 (pt) | 2016-06-13 | 2019-04-02 | Gilead Sciences, Inc. | composto, composição farmacêutica, método para tratar um paciente com uma doença ou condição mediada pelo menos em parte por fxr, e, uso de um composto. |
CA2968836A1 (en) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
EA037520B1 (ru) | 2016-07-20 | 2021-04-07 | Новартис Аг | Производные аминопиридина и их применение в качестве селективных ингибиторов alk–2 |
PL3600309T3 (pl) | 2017-03-28 | 2022-11-07 | Gilead Sciences, Inc. | Skojarzenia terapeutyczne do leczenia chorób wątroby |
BR122020005073A2 (pt) | 2017-08-04 | 2020-10-13 | Skyhawk Therapeutics, Inc. | Composto, composição farmacêutica e uso do composto |
TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
AU2019301944B2 (en) | 2018-07-10 | 2022-02-24 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases |
TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
JP7265635B2 (ja) | 2019-01-15 | 2023-04-26 | ギリアード サイエンシーズ, インコーポレイテッド | Fxr(nr1h4)調節化合物 |
MA54758A (fr) | 2019-01-18 | 2022-04-27 | Astrazeneca Ab | Inhibiteurs de pcsk9 et leurs procédés d'utilisation |
JP2022521467A (ja) | 2019-02-05 | 2022-04-08 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
KR20210129128A (ko) | 2019-02-19 | 2021-10-27 | 길리애드 사이언시즈, 인코포레이티드 | Fxr 효능제의 고체 형태 |
US11560388B2 (en) * | 2019-03-19 | 2023-01-24 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
US11129829B2 (en) | 2019-06-17 | 2021-09-28 | Skyhawk Therapeutics, Inc. | Methods for modulating splicing |
BR112022007627A2 (pt) | 2019-10-25 | 2022-07-12 | Gilead Sciences Inc | Compostos moduladores do glp-1r |
EP4061367A1 (en) | 2019-11-22 | 2022-09-28 | Incyte Corporation | Combination therapy comprising an alk2 inhibitor and a jak2 inhibitor |
MX2022014356A (es) | 2020-05-15 | 2023-03-09 | Algen Biotechnologies Inc | Ciertas composiciones quimicas y metodos de uso de las mismas. |
WO2021257532A1 (en) | 2020-06-16 | 2021-12-23 | Incyte Corporation | Alk2 inhibitors for the treatment of anemia |
WO2022109182A1 (en) | 2020-11-20 | 2022-05-27 | Gilead Sciences, Inc. | Polyheterocyclic glp-1 r modulating compounds |
US11932630B2 (en) | 2021-04-16 | 2024-03-19 | Novartis Ag | Heteroaryl aminopropanol derivatives |
JP2024514009A (ja) | 2021-04-21 | 2024-03-27 | ギリアード サイエンシーズ, インコーポレイテッド | カルボキシ-ベンズイミダゾールglp-1r調節化合物 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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DE4208254A1 (de) | 1992-03-14 | 1993-09-16 | Hoechst Ag | Substituierte pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel und fungizid |
AU1631699A (en) | 1997-12-18 | 1999-07-05 | E.I. Du Pont De Nemours And Company | Cyclohexylamine arthropodicides and fungicides |
AU2001233044A1 (en) | 2000-01-28 | 2001-08-07 | Akkadix Corporation | Methods for killing nematodes and nematode eggs using bis-amino-1,2,4-thiadiazoles |
US7199147B2 (en) | 2001-06-12 | 2007-04-03 | Dainippon Sumitomo Pharma Co., Ltd. | Rho kinase inhibitors |
EP1689722A2 (en) * | 2003-10-10 | 2006-08-16 | Bayer Pharmaceuticals Corporation | 4-aminopyrimidine derivatives for treatment of hyperproliferative disorders |
US7880000B2 (en) * | 2004-05-07 | 2011-02-01 | Amgen Inc. | Protein kinase modulators and method of use |
DE102005032838A1 (de) * | 2005-07-14 | 2007-02-08 | Merck Patent Gmbh | Mischung von Onium-Alkylsulfonaten und Onium-Alkylsulfiten |
JPWO2007063839A1 (ja) * | 2005-11-30 | 2009-05-07 | 塩野義製薬株式会社 | シクロヘキサン誘導体 |
TW200938203A (en) | 2007-12-17 | 2009-09-16 | Intervet Int Bv | Anthelmintic agents and their use |
TW201041868A (en) | 2009-03-20 | 2010-12-01 | Intervet Int Bv | Anthelmintic agents and their use |
TW201111358A (en) | 2009-06-18 | 2011-04-01 | Intervet Int Bv | Anthelmintic agents and their use |
IN2012DN02471A (es) * | 2009-10-09 | 2015-08-21 | Irm Llc | |
EP2569302A1 (en) * | 2010-05-13 | 2013-03-20 | Amgen, Inc | Heteroaryloxyheterocyclyl compounds as pde10 inhibitors |
US8952037B2 (en) * | 2010-05-13 | 2015-02-10 | Amgen Inc. | Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors |
EP2468096A1 (en) | 2010-12-21 | 2012-06-27 | Intervet International BV | Anthelmintic combinations |
US8530461B2 (en) * | 2011-12-29 | 2013-09-10 | Boehringer Ingelheim International Gmbh | Azetidine derivatives |
EP2882733B1 (en) * | 2012-08-08 | 2017-04-26 | Novartis Tiergesundheit AG | Substituted azines as pesticides |
ES2893777T3 (es) * | 2012-11-20 | 2022-02-10 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos y composiciones antihelmínticas y procedimiento de utilización de los mismos |
HRP20211855T1 (hr) * | 2013-03-12 | 2022-03-04 | Vertex Pharmaceuticals Incorporated | Inhibitori dnk-pk |
JP6140373B2 (ja) | 2013-11-18 | 2017-05-31 | ノバルティス ティーアゲズントハイト アーゲー | 新規化合物 |
AU2015264336B2 (en) | 2014-05-19 | 2018-08-30 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic compounds |
-
2016
- 2016-01-20 CN CN201680010899.2A patent/CN107257793A/zh active Pending
- 2016-01-20 EP EP16702865.3A patent/EP3247701B1/en active Active
- 2016-01-20 WO PCT/US2016/014148 patent/WO2016118638A1/en active Application Filing
- 2016-01-20 AU AU2016209321A patent/AU2016209321B2/en not_active Ceased
- 2016-01-20 JP JP2017538327A patent/JP6771469B2/ja active Active
- 2016-01-20 US US15/544,837 patent/US10597364B2/en active Active
- 2016-01-20 NZ NZ734082A patent/NZ734082A/en not_active IP Right Cessation
- 2016-01-20 MX MX2017009408A patent/MX2017009408A/es unknown
- 2016-01-20 CA CA2973873A patent/CA2973873A1/en not_active Abandoned
- 2016-01-20 BR BR112017015273-8A patent/BR112017015273A2/pt active Search and Examination
- 2016-01-20 ES ES16702865T patent/ES2907461T3/es active Active
-
2019
- 2019-04-18 AU AU2019202773A patent/AU2019202773B2/en not_active Ceased
-
2020
- 2020-06-30 AU AU2020204400A patent/AU2020204400A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2020204400A1 (en) | 2020-07-30 |
ES2907461T3 (es) | 2022-04-25 |
US10597364B2 (en) | 2020-03-24 |
JP2018502877A (ja) | 2018-02-01 |
US20180009754A1 (en) | 2018-01-11 |
EP3247701B1 (en) | 2021-09-22 |
CA2973873A1 (en) | 2016-07-28 |
EP3247701A1 (en) | 2017-11-29 |
NZ734082A (en) | 2019-01-25 |
JP6771469B2 (ja) | 2020-10-21 |
AU2016209321A1 (en) | 2017-08-17 |
CN107257793A (zh) | 2017-10-17 |
BR112017015273A2 (pt) | 2018-01-09 |
AU2019202773A1 (en) | 2019-05-16 |
WO2016118638A1 (en) | 2016-07-28 |
AU2016209321B2 (en) | 2019-05-09 |
AU2019202773B2 (en) | 2020-07-02 |
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