MX2016017081A - Tratamiento de hipertrigliceridemia grave. - Google Patents
Tratamiento de hipertrigliceridemia grave.Info
- Publication number
- MX2016017081A MX2016017081A MX2016017081A MX2016017081A MX2016017081A MX 2016017081 A MX2016017081 A MX 2016017081A MX 2016017081 A MX2016017081 A MX 2016017081A MX 2016017081 A MX2016017081 A MX 2016017081A MX 2016017081 A MX2016017081 A MX 2016017081A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- severe hypertriglyceridemia
- mbx
- type
- hypertriglyceridemia
- Prior art date
Links
- 208000006575 hypertriglyceridemia Diseases 0.000 title abstract 2
- JWHYSEDOYMYMNM-QGZVFWFLSA-N 2-[4-[(2r)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic acid Chemical compound C([C@@H](OCC)CSC=1C=C(C)C(OCC(O)=O)=CC=1)OC1=CC=C(C(F)(F)F)C=C1 JWHYSEDOYMYMNM-QGZVFWFLSA-N 0.000 abstract 2
- 208000001021 Hyperlipoproteinemia Type I Diseases 0.000 abstract 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 1
- 206010060749 Type I hyperlipidaemia Diseases 0.000 abstract 1
- 206010060755 Type V hyperlipidaemia Diseases 0.000 abstract 1
- 238000002617 apheresis Methods 0.000 abstract 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 abstract 1
- 229940125753 fibrate Drugs 0.000 abstract 1
- 229960003512 nicotinic acid Drugs 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 abstract 1
- 229940012843 omega-3 fatty acid Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Tratamiento de hipertrigliceridemia grave, tal como hiperlipoproteinemia de tipo I o tipo V, mediante terapia con MBX-8025 o una sal de MBX-8025, solo o en combinación con uno o más de un fibrato, niacina y un ácido graso omega-3, opcionalmente acompañado por aféresis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462017444P | 2014-06-26 | 2014-06-26 | |
PCT/US2015/037596 WO2015200580A1 (en) | 2014-06-26 | 2015-06-25 | Treatment of severe hypertriglyceridemia |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016017081A true MX2016017081A (es) | 2017-05-01 |
Family
ID=53511030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016017081A MX2016017081A (es) | 2014-06-26 | 2015-06-25 | Tratamiento de hipertrigliceridemia grave. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20150374649A1 (es) |
EP (1) | EP3160458A1 (es) |
JP (1) | JP2017519028A (es) |
KR (1) | KR20170020514A (es) |
CN (1) | CN106470675A (es) |
AU (1) | AU2015279905A1 (es) |
BR (1) | BR112016028918A2 (es) |
CA (1) | CA2951280A1 (es) |
CL (1) | CL2016003290A1 (es) |
EA (1) | EA201790091A1 (es) |
HK (1) | HK1231380A1 (es) |
IL (1) | IL249757A0 (es) |
MX (1) | MX2016017081A (es) |
PH (1) | PH12016502415A1 (es) |
SG (1) | SG11201610243YA (es) |
WO (1) | WO2015200580A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
EA032358B1 (ru) | 2014-03-20 | 2019-05-31 | Саймабэй Терапьютикс, Инк. | Лечение внутрипеченочных холестатических заболеваний |
SI3129018T1 (sl) | 2014-04-11 | 2020-02-28 | Cymabay Therapeutics, Inc. | Zdravljenje nafld in nash |
US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
CA3085951C (en) * | 2017-12-21 | 2022-10-11 | Kowa Company, Ltd. | Methods of treatment of hypertriglyceridemia |
US20210145774A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of alcoholic liver disease |
US20210145775A1 (en) | 2019-11-14 | 2021-05-20 | Cymabay Therapeutics, Inc. | Treatment of intestinal barrier dysfunction and associated diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005042478A2 (en) | 2003-09-19 | 2005-05-12 | Janssen Pharmaceutica, N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
ES2586127T3 (es) * | 2010-03-30 | 2016-10-11 | Novartis Ag | Usos de inhibidores de DGAT1 |
-
2015
- 2015-06-25 SG SG11201610243YA patent/SG11201610243YA/en unknown
- 2015-06-25 EP EP15734013.4A patent/EP3160458A1/en not_active Withdrawn
- 2015-06-25 JP JP2016575073A patent/JP2017519028A/ja not_active Withdrawn
- 2015-06-25 MX MX2016017081A patent/MX2016017081A/es unknown
- 2015-06-25 WO PCT/US2015/037596 patent/WO2015200580A1/en active Application Filing
- 2015-06-25 AU AU2015279905A patent/AU2015279905A1/en not_active Abandoned
- 2015-06-25 KR KR1020177002016A patent/KR20170020514A/ko unknown
- 2015-06-25 CN CN201580033722.XA patent/CN106470675A/zh active Pending
- 2015-06-25 US US14/749,934 patent/US20150374649A1/en not_active Abandoned
- 2015-06-25 BR BR112016028918A patent/BR112016028918A2/pt not_active Application Discontinuation
- 2015-06-25 CA CA2951280A patent/CA2951280A1/en not_active Abandoned
- 2015-06-25 EA EA201790091A patent/EA201790091A1/ru unknown
-
2016
- 2016-12-02 PH PH12016502415A patent/PH12016502415A1/en unknown
- 2016-12-22 CL CL2016003290A patent/CL2016003290A1/es unknown
- 2016-12-25 IL IL249757A patent/IL249757A0/en unknown
-
2017
- 2017-05-18 HK HK17105013.3A patent/HK1231380A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CL2016003290A1 (es) | 2017-09-08 |
WO2015200580A1 (en) | 2015-12-30 |
SG11201610243YA (en) | 2017-01-27 |
EP3160458A1 (en) | 2017-05-03 |
CN106470675A (zh) | 2017-03-01 |
PH12016502415A1 (en) | 2017-02-27 |
AU2015279905A1 (en) | 2017-02-02 |
CA2951280A1 (en) | 2015-12-30 |
EA201790091A1 (ru) | 2017-07-31 |
IL249757A0 (en) | 2017-02-28 |
HK1231380A1 (zh) | 2017-12-22 |
KR20170020514A (ko) | 2017-02-22 |
BR112016028918A2 (pt) | 2017-08-22 |
US20150374649A1 (en) | 2015-12-31 |
JP2017519028A (ja) | 2017-07-13 |
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