MX2016010791A - Inmunoterapia con multiples objetivos dirigida por biomarcadores. - Google Patents
Inmunoterapia con multiples objetivos dirigida por biomarcadores.Info
- Publication number
- MX2016010791A MX2016010791A MX2016010791A MX2016010791A MX2016010791A MX 2016010791 A MX2016010791 A MX 2016010791A MX 2016010791 A MX2016010791 A MX 2016010791A MX 2016010791 A MX2016010791 A MX 2016010791A MX 2016010791 A MX2016010791 A MX 2016010791A
- Authority
- MX
- Mexico
- Prior art keywords
- biomarker
- disease
- subject
- fusion protein
- biological sample
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title abstract 7
- 238000009169 immunotherapy Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 5
- 241000186781 Listeria Species 0.000 abstract 3
- 239000012472 biological sample Substances 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 3
- 102000037865 fusion proteins Human genes 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464403—Receptors for growth factors
- A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/464488—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4648—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/47—Brain; Nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/49—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
Esta invención proporciona métodos y composiciones para su uso en la evaluación de la expresión de biomarcadores en una enfermedad y para proporcionar un enfoque inmunoterapéutico basado en Listeria con múltiples objetivos contra dicha enfermedad. En un aspecto relacionado, la invención se refiere a un método para tratar una enfermedad en un sujeto, el método comprende las etapas de: a. obtener una muestra biológica de dicho sujeto; b. evaluar la expresión de un número predeterminado de biomarcadores en dicha muestra biológica; c. administrar a dicho sujeto una composición que comprende una cepa de Listeria recombinante, dicha cepa comprende una secuencia de ácido nucleico que codifica al menos una proteína de fusión, en donde dicha proteína de fusión comprende un biomarcador identificado en dicha muestra biológica, en donde dicho biomarcador se asocia con dicha enfermedad, en donde dicho biomarcador se fusiona a un polipéptido que contiene PEST, y en donde cada proteína de fusión dentro de dicha Listeria comprende un biomarcador diferente, y de esta manera se trata dicha enfermedad en dicho sujeto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461941072P | 2014-02-18 | 2014-02-18 | |
PCT/US2015/016348 WO2015126921A1 (en) | 2014-02-18 | 2015-02-18 | Biomarker directed multi-target immunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016010791A true MX2016010791A (es) | 2017-04-27 |
Family
ID=53878905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016010791A MX2016010791A (es) | 2014-02-18 | 2015-02-18 | Inmunoterapia con multiples objetivos dirigida por biomarcadores. |
Country Status (14)
Country | Link |
---|---|
US (1) | US10143734B2 (es) |
EP (1) | EP3107566A4 (es) |
JP (1) | JP2017511796A (es) |
KR (1) | KR20160130774A (es) |
CN (1) | CN106456726A (es) |
AU (1) | AU2015219161A1 (es) |
BR (1) | BR112016019057A2 (es) |
CA (1) | CA2947358A1 (es) |
HK (1) | HK1232139A1 (es) |
IL (1) | IL247300A0 (es) |
MX (1) | MX2016010791A (es) |
RU (1) | RU2016136855A (es) |
SG (1) | SG11201606677XA (es) |
WO (1) | WO2015126921A1 (es) |
Families Citing this family (14)
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US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
US8771702B2 (en) * | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
CA2829960A1 (en) | 2011-03-11 | 2012-09-20 | John Rothman | Listeria-based adjuvants |
BR112014022662A2 (pt) | 2012-03-12 | 2017-10-03 | Advaxis Inc | Inibição da função de célula supressora seguindo tratamento de vacina de listeria |
CA2947358A1 (en) | 2014-02-18 | 2015-08-27 | Advaxis, Inc. | Biomarker directed multi-target immunotherapy |
SG11201608820WA (en) | 2014-04-24 | 2016-11-29 | Advaxis Inc | Recombinant listeria vaccine strains and methods of producing the same |
MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
IL259931B2 (en) | 2015-12-16 | 2024-02-01 | Gritstone Bio Inc | Identification of neo-antigens, preparation, and use |
SG11201806392XA (en) * | 2016-01-27 | 2018-08-30 | Advaxis Inc | Personalized delivery vector-based immunotherapy and uses thereof |
KR20190082850A (ko) | 2016-11-30 | 2019-07-10 | 어드박시스, 인크. | 반복되는 암 돌연변이를 표적화하는 면역원 조성물 및 그것의 사용 방법 |
CA3075849A1 (en) | 2017-09-19 | 2019-03-28 | Advaxis, Inc. | Compositions and methods for lyophilization of bacteria or listeria strains |
AU2018348165A1 (en) | 2017-10-10 | 2020-05-21 | Gritstone Bio, Inc. | Neoantigen identification using hotspots |
KR20200090855A (ko) | 2017-11-22 | 2020-07-29 | 그릿스톤 온콜로지, 인코포레이티드 | 신생항원에 대한 접합 에피토프 제시 감소 |
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KR20170068560A (ko) | 2014-10-14 | 2017-06-19 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 암 치료에서의 병용 요법 |
MA41217A (fr) | 2014-12-19 | 2017-10-24 | Advaxis Inc | Polythérapies ayant des souches de listeria recombinées |
US20160220652A1 (en) | 2015-02-03 | 2016-08-04 | Advaxis, Inc. | Methods of using recombinant listeria vaccine strains in disease immunotherapy |
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WO2016126878A2 (en) | 2015-02-03 | 2016-08-11 | The Trustees Of The University Of Pennsylvania | Listeria-based immunomodulation |
MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
WO2016154412A2 (en) | 2015-03-26 | 2016-09-29 | The Trustees Of The University Of Pennsylvania | Combination of a pd-1 antagonist and a listeria based vaccine for treating pancreatic cancer |
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KR20180027501A (ko) | 2015-06-24 | 2018-03-14 | 어드박시스, 인크. | 맞춤형 전달 벡터-기반 면역 요법을 위한 제조 장치 및 공정 |
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MA42841A (fr) | 2015-09-15 | 2018-07-25 | Advaxis Inc | Procédé de fabrication d'une formulation immunothérapeutique comprenant une souche de listeria de recombinaison |
JP2018527382A (ja) | 2015-09-17 | 2018-09-20 | アドバクシス, インコーポレイテッド | 組み換え型リステリアワクチン株および癌免疫療法におけるその使用方法 |
TW201722444A (zh) | 2015-10-14 | 2017-07-01 | 艾***公司 | 重組李斯特菌疫苗菌株及在癌症免疫治療中使用該菌株之方法 |
WO2017085691A1 (en) | 2015-11-20 | 2017-05-26 | Advaxis, Inc. | Manufacturing device and method of an immunotherapeutic formulation comprising a recombinant listeria strain |
US20180360940A1 (en) | 2015-12-16 | 2018-12-20 | Advaxis, Inc. | Listeria-based immunotherapy and methods of use thereof |
SG11201806392XA (en) | 2016-01-27 | 2018-08-30 | Advaxis Inc | Personalized delivery vector-based immunotherapy and uses thereof |
WO2018009461A1 (en) | 2016-07-05 | 2018-01-11 | Advaxis, Inc. | Listeria-based immunogenic compositions comprising wilms tumor protein antigens and methods of use thereof |
-
2015
- 2015-02-18 CA CA2947358A patent/CA2947358A1/en not_active Abandoned
- 2015-02-18 JP JP2016552623A patent/JP2017511796A/ja active Pending
- 2015-02-18 US US15/119,661 patent/US10143734B2/en active Active
- 2015-02-18 SG SG11201606677XA patent/SG11201606677XA/en unknown
- 2015-02-18 EP EP15751948.9A patent/EP3107566A4/en not_active Withdrawn
- 2015-02-18 BR BR112016019057A patent/BR112016019057A2/pt not_active Application Discontinuation
- 2015-02-18 KR KR1020167024928A patent/KR20160130774A/ko unknown
- 2015-02-18 MX MX2016010791A patent/MX2016010791A/es unknown
- 2015-02-18 AU AU2015219161A patent/AU2015219161A1/en not_active Abandoned
- 2015-02-18 RU RU2016136855A patent/RU2016136855A/ru not_active Application Discontinuation
- 2015-02-18 WO PCT/US2015/016348 patent/WO2015126921A1/en active Application Filing
- 2015-02-18 CN CN201580009039.2A patent/CN106456726A/zh active Pending
-
2016
- 2016-08-16 IL IL247300A patent/IL247300A0/en unknown
-
2017
- 2017-06-12 HK HK17105785.9A patent/HK1232139A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HK1232139A1 (zh) | 2018-01-05 |
CA2947358A1 (en) | 2015-08-27 |
SG11201606677XA (en) | 2016-09-29 |
US20170106072A1 (en) | 2017-04-20 |
EP3107566A4 (en) | 2017-10-11 |
JP2017511796A (ja) | 2017-04-27 |
RU2016136855A (ru) | 2018-03-22 |
CN106456726A (zh) | 2017-02-22 |
IL247300A0 (en) | 2016-09-29 |
EP3107566A1 (en) | 2016-12-28 |
BR112016019057A2 (pt) | 2017-10-10 |
AU2015219161A1 (en) | 2016-09-29 |
US10143734B2 (en) | 2018-12-04 |
WO2015126921A1 (en) | 2015-08-27 |
KR20160130774A (ko) | 2016-11-14 |
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