MX2016001837A - Receptores de celulas t. - Google Patents
Receptores de celulas t.Info
- Publication number
- MX2016001837A MX2016001837A MX2016001837A MX2016001837A MX2016001837A MX 2016001837 A MX2016001837 A MX 2016001837A MX 2016001837 A MX2016001837 A MX 2016001837A MX 2016001837 A MX2016001837 A MX 2016001837A MX 2016001837 A MX2016001837 A MX 2016001837A
- Authority
- MX
- Mexico
- Prior art keywords
- tcrs
- lmp2a
- tcr
- complex
- ebv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/03—Herpetoviridae, e.g. pseudorabies virus
- C07K14/05—Epstein-Barr virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6056—Antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16271—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a receptores de células T (TCRs) que se unen al péptido CLGGLLTMV restringido en HLA-A2 derivado de la proteína LMP2A del Virus de Epstein Barr (EBV). Los TCRs de la invención comprenden un dominio variable de la cadena alfa de TCR y/o un dominio variable beta de TCR. Ciertos TCRs preferidos se unen también a las variantes de péptido natural SLGGLLTMV y CLGGLITMV presentadas como un complejo péptido-HLA-A2. Los TCRs de la invención demuestran excelentes perfiles de especificidad para aquellos epítopos de LMP2A y tienen afinidades de unión para el complejo que se traducen en una capacidad mejorada para reconocer el complejo en comparación con un TCR de referencia soluble que tiene la secuencia extracelular de la cadena alfa de TCR de LMP2A de EBV nativa mostrada en la figura 3 (SEQ ID NO: 4) y la secuencia extracelular de la cadena beta de TCR de LMP2A de EBV nativa mostrada en la figura 4 (SEQ ID NO: 5).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1314404.3A GB201314404D0 (en) | 2013-08-12 | 2013-08-12 | T Cell Receptors |
PCT/GB2014/052464 WO2015022520A1 (en) | 2013-08-12 | 2014-08-12 | T cell receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016001837A true MX2016001837A (es) | 2016-05-24 |
Family
ID=49262046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016001837A MX2016001837A (es) | 2013-08-12 | 2014-08-12 | Receptores de celulas t. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20160199479A1 (es) |
EP (1) | EP3033353A1 (es) |
JP (1) | JP2016528244A (es) |
KR (1) | KR20160058767A (es) |
CN (1) | CN106414482A (es) |
AU (1) | AU2014307725A1 (es) |
BR (1) | BR112016002687A2 (es) |
CA (1) | CA2920444A1 (es) |
EA (1) | EA201690180A1 (es) |
GB (1) | GB201314404D0 (es) |
HK (1) | HK1221724A1 (es) |
MX (1) | MX2016001837A (es) |
PH (1) | PH12016500272A1 (es) |
SG (1) | SG11201600849UA (es) |
WO (1) | WO2015022520A1 (es) |
ZA (1) | ZA201600959B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106279404A (zh) * | 2015-05-20 | 2017-01-04 | 广州市香雪制药股份有限公司 | 一种可溶且稳定的异质二聚tcr |
AU2016323017B2 (en) * | 2015-09-15 | 2020-11-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing HLA-Cw8 restricted mutated KRAS |
WO2017079747A1 (en) | 2015-11-06 | 2017-05-11 | Regents Of The University Of Minnesota | Activation of resident memory t cells for cancer immunotherapy |
GB201520191D0 (en) * | 2015-11-16 | 2015-12-30 | Cancer Rec Tech Ltd | T-cell receptor and uses thereof |
US10611816B2 (en) * | 2016-08-02 | 2020-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-KRAS-G12D T cell receptors |
GB201709866D0 (en) | 2017-06-20 | 2017-08-02 | Immunocore Ltd | T cell receptors |
DE102017114737A1 (de) * | 2017-06-30 | 2019-01-03 | Immatics Biotechnologies Gmbh | Neue T-Zellrezeptoren und deren Verwendung in Immuntherapie |
US20210093713A1 (en) * | 2017-08-03 | 2021-04-01 | Regents Of The University Of Minnesota | Activation of resident memory t cells for the treatment of cancer |
CN110818802B (zh) * | 2018-08-08 | 2022-02-08 | 华夏英泰(北京)生物技术有限公司 | 一种嵌合t细胞受体star及其应用 |
CN109306005B (zh) * | 2018-09-30 | 2019-11-15 | 清华大学 | 一种eb病毒特异性t细胞抗原受体及其应用 |
CN113423724B (zh) * | 2018-12-27 | 2023-11-24 | 深圳华大生命科学研究院 | Ebv表位高亲和力t细胞受体 |
GB201904328D0 (en) * | 2019-03-28 | 2019-05-15 | Immunocore Ltd | Specific binding molecules |
GB201909509D0 (en) * | 2019-07-02 | 2019-08-14 | Immunocore Ltd | Peptide-MHC complexes |
EP3786178A1 (en) | 2019-08-30 | 2021-03-03 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Tcr constructs specific for ebv-derived antigens |
WO2021211455A1 (en) * | 2020-04-13 | 2021-10-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hla class i-restricted t cell receptors against lmp2 |
CN111440246B (zh) * | 2020-04-16 | 2022-03-18 | 成都仕康美生物科技有限公司 | 靶向HLA-B的嵌合抗原受体、编码基因、CAR-Tregs细胞及其制备方法、用途 |
CA3217738A1 (en) | 2021-05-05 | 2022-05-04 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
EP4091627A1 (en) | 2021-05-21 | 2022-11-23 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Tcr constructs specific for magea4-derived epitopes |
WO2023122337A1 (en) | 2021-12-23 | 2023-06-29 | Sana Biotechnology, Inc. | Chimeric antigen receptor (car) t cells for treating autoimmune disease and associated methods |
WO2023242343A1 (en) * | 2022-06-15 | 2023-12-21 | Immunoscape Pte. Ltd. | Human t cell receptors specific for antigenic peptides derived from mitogen-activated protein kinase 8 interacting protein 2 (mapk8ip2), epstein-barr virus or human endogenous retrovirus, and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0223399D0 (en) * | 2002-10-09 | 2002-11-13 | Avidex Ltd | Receptors |
GB0917090D0 (en) * | 2009-09-29 | 2009-11-11 | Ucl Biomedica Plc | T-cell receptor |
GB0917094D0 (en) * | 2009-09-29 | 2009-11-11 | Ucl Biomedica Plc | T-cell receptor |
PL2618835T3 (pl) * | 2010-09-20 | 2017-12-29 | Biontech Cell & Gene Therapies Gmbh | Swoiste względem antygenu receptory komórek T i epitopy dla komórek T |
-
2013
- 2013-08-12 GB GBGB1314404.3A patent/GB201314404D0/en not_active Ceased
-
2014
- 2014-08-12 EA EA201690180A patent/EA201690180A1/ru unknown
- 2014-08-12 AU AU2014307725A patent/AU2014307725A1/en not_active Abandoned
- 2014-08-12 KR KR1020167005733A patent/KR20160058767A/ko not_active Application Discontinuation
- 2014-08-12 BR BR112016002687A patent/BR112016002687A2/pt unknown
- 2014-08-12 CN CN201480056190.7A patent/CN106414482A/zh active Pending
- 2014-08-12 WO PCT/GB2014/052464 patent/WO2015022520A1/en active Application Filing
- 2014-08-12 JP JP2016533954A patent/JP2016528244A/ja not_active Withdrawn
- 2014-08-12 CA CA2920444A patent/CA2920444A1/en active Pending
- 2014-08-12 EP EP14761391.3A patent/EP3033353A1/en not_active Withdrawn
- 2014-08-12 MX MX2016001837A patent/MX2016001837A/es unknown
- 2014-08-12 SG SG11201600849UA patent/SG11201600849UA/en unknown
-
2016
- 2016-02-08 US US15/017,765 patent/US20160199479A1/en not_active Abandoned
- 2016-02-10 PH PH12016500272A patent/PH12016500272A1/en unknown
- 2016-02-11 ZA ZA2016/00959A patent/ZA201600959B/en unknown
- 2016-08-15 HK HK16109739.9A patent/HK1221724A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
SG11201600849UA (en) | 2016-03-30 |
GB201314404D0 (en) | 2013-09-25 |
KR20160058767A (ko) | 2016-05-25 |
EA201690180A1 (ru) | 2016-07-29 |
JP2016528244A (ja) | 2016-09-15 |
CA2920444A1 (en) | 2015-02-19 |
EP3033353A1 (en) | 2016-06-22 |
AU2014307725A1 (en) | 2016-03-03 |
CN106414482A (zh) | 2017-02-15 |
BR112016002687A2 (pt) | 2017-09-12 |
WO2015022520A1 (en) | 2015-02-19 |
US20160199479A1 (en) | 2016-07-14 |
PH12016500272A1 (en) | 2016-05-02 |
HK1221724A1 (zh) | 2017-06-09 |
ZA201600959B (en) | 2017-11-29 |
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