MX2016000163A - Pirazolpiridinas sustituidas. - Google Patents
Pirazolpiridinas sustituidas.Info
- Publication number
- MX2016000163A MX2016000163A MX2016000163A MX2016000163A MX2016000163A MX 2016000163 A MX2016000163 A MX 2016000163A MX 2016000163 A MX2016000163 A MX 2016000163A MX 2016000163 A MX2016000163 A MX 2016000163A MX 2016000163 A MX2016000163 A MX 2016000163A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- pyridinamines
- preparing
- substituted pyrazolo
- hyperproliferative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos de pirazolpiridina sustituidas de fórmula general I según se los describe y define aquí, métodos para preparar dichos compuestos, compuestos intermediarios útiles para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden a dichos compuestos y el uso de dichos compuestos para elaborar una composición farmacéutica para el tratamiento o la profilaxis de una enfermedad, en particular de un trastorno hiperproliferativo y/o de angiogénesis, como único agente o en combinación con otros ingredientes activos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13175526 | 2013-07-08 | ||
EP13194902 | 2013-11-28 | ||
EP13195131 | 2013-11-29 | ||
PCT/EP2014/064347 WO2015004024A1 (en) | 2013-07-08 | 2014-07-04 | Substituted pyrazolo-pyridinamines |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016000163A true MX2016000163A (es) | 2016-04-15 |
Family
ID=51162789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016000163A MX2016000163A (es) | 2013-07-08 | 2014-07-04 | Pirazolpiridinas sustituidas. |
Country Status (24)
Country | Link |
---|---|
US (1) | US20160159789A1 (es) |
EP (1) | EP3019505A1 (es) |
JP (1) | JP2016527216A (es) |
KR (1) | KR20160030239A (es) |
CN (1) | CN105531279A (es) |
AP (1) | AP2016009025A0 (es) |
AU (1) | AU2014289415A1 (es) |
CA (1) | CA2917380A1 (es) |
CL (1) | CL2016000038A1 (es) |
CR (1) | CR20160016A (es) |
CU (1) | CU20160003A7 (es) |
DO (1) | DOP2016000007A (es) |
EA (1) | EA201690183A1 (es) |
HK (1) | HK1223362A1 (es) |
IL (1) | IL243273A0 (es) |
MX (1) | MX2016000163A (es) |
NI (1) | NI201600006A (es) |
PE (1) | PE20160125A1 (es) |
PH (1) | PH12016500054A1 (es) |
SG (1) | SG11201510391VA (es) |
TN (1) | TN2016000005A1 (es) |
UY (1) | UY35651A (es) |
WO (1) | WO2015004024A1 (es) |
ZA (1) | ZA201600275B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201605867A (zh) * | 2013-11-20 | 2016-02-16 | 拜耳製藥公司 | 噻吩并嘧啶 |
DK3285809T3 (da) * | 2015-04-20 | 2019-11-18 | Effector Therapeutics Inc | Inhibitorer af immunkontrolpunktsmodulatorer til anvendelse i behandling af kræft og infektioner. |
GB201520500D0 (en) * | 2015-11-20 | 2016-01-06 | Medical Res Council Technology | Compounds |
US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
WO2018039310A1 (en) | 2016-08-24 | 2018-03-01 | Arqule, Inc. | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
WO2018134335A1 (en) * | 2017-01-20 | 2018-07-26 | Bayer Pharma Aktiengesellschaft | Substituted imidazopyridinpyrimidines |
JP2022539840A (ja) | 2019-07-10 | 2022-09-13 | フンダシオ オスピタル ウニベルシタリ バル デブロン-インスティテュート デ レセルカ | Mapキナーゼ相互作用セリン/スレオニン-プロテインキナーゼ1(mnk1)及びmapキナーゼ相互作用セリン/スレオニン-プロテインキナーゼ2(mnk2)の阻害剤、癌治療及び治療的組合せ |
CN110483523B (zh) * | 2019-08-27 | 2022-11-22 | 药雅科技(上海)有限公司 | 一种吡唑并嘧啶衍生物表皮生长因子抑制剂及其制备方法与用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602004003952T2 (de) * | 2003-07-24 | 2007-11-08 | Bayer Pharmaceuticals Corp., West Haven | Substituierte tetrahydrobenzothienopyrimidinamine verbindungen geeignet zur behandlung von hyper-proliferative disorders |
WO2007076161A2 (en) * | 2005-12-27 | 2007-07-05 | Myriad Genetics, Inc | Compounds with therapeutic activity |
EP1889847A1 (en) * | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidines for pharmaceutical compositions |
KR20100117686A (ko) * | 2008-02-29 | 2010-11-03 | 어레이 바이오파마 인크. | 피라졸[3,4-b]피리딘 raf 저해물질 |
JP2013503194A (ja) * | 2009-08-28 | 2013-01-31 | アレイ バイオファーマ、インコーポレイテッド | Rafキナーゼを阻害するための1H−ピラゾロ[3,4−B]ピリジン化合物 |
MX2012009851A (es) * | 2010-02-26 | 2012-09-12 | Boehringer Ingelheim Int | Tienopirimidinas que contienen un grupo alquilo sustituido para composiciones farmaceuticas. |
US9351974B2 (en) * | 2011-11-10 | 2016-05-31 | OSI Pharmaceuticals, LLC | Substituted pteridinones for the treatment of cancer |
-
2014
- 2014-07-04 AU AU2014289415A patent/AU2014289415A1/en not_active Abandoned
- 2014-07-04 CN CN201480049419.4A patent/CN105531279A/zh active Pending
- 2014-07-04 AP AP2016009025A patent/AP2016009025A0/en unknown
- 2014-07-04 CA CA2917380A patent/CA2917380A1/en not_active Abandoned
- 2014-07-04 MX MX2016000163A patent/MX2016000163A/es unknown
- 2014-07-04 JP JP2016524760A patent/JP2016527216A/ja active Pending
- 2014-07-04 EP EP14736772.6A patent/EP3019505A1/en not_active Withdrawn
- 2014-07-04 KR KR1020167003079A patent/KR20160030239A/ko not_active Application Discontinuation
- 2014-07-04 EA EA201690183A patent/EA201690183A1/ru unknown
- 2014-07-04 PE PE2016000029A patent/PE20160125A1/es not_active Application Discontinuation
- 2014-07-04 WO PCT/EP2014/064347 patent/WO2015004024A1/en active Application Filing
- 2014-07-04 SG SG11201510391VA patent/SG11201510391VA/en unknown
- 2014-07-04 TN TN2016000005A patent/TN2016000005A1/en unknown
- 2014-07-04 US US14/903,423 patent/US20160159789A1/en not_active Abandoned
- 2014-07-08 UY UY35651A patent/UY35651A/es not_active Application Discontinuation
-
2015
- 2015-12-21 IL IL243273A patent/IL243273A0/en unknown
-
2016
- 2016-01-07 PH PH12016500054A patent/PH12016500054A1/en unknown
- 2016-01-08 CR CR20160016A patent/CR20160016A/es unknown
- 2016-01-08 CL CL2016000038A patent/CL2016000038A1/es unknown
- 2016-01-08 CU CUP2016000003A patent/CU20160003A7/es unknown
- 2016-01-08 NI NI201600006A patent/NI201600006A/es unknown
- 2016-01-08 DO DO2016000007A patent/DOP2016000007A/es unknown
- 2016-01-13 ZA ZA2016/00275A patent/ZA201600275B/en unknown
- 2016-10-05 HK HK16111573.4A patent/HK1223362A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HK1223362A1 (zh) | 2017-07-28 |
NI201600006A (es) | 2016-02-12 |
UY35651A (es) | 2015-02-27 |
EP3019505A1 (en) | 2016-05-18 |
CR20160016A (es) | 2016-03-04 |
PH12016500054A1 (en) | 2016-04-04 |
DOP2016000007A (es) | 2016-02-15 |
JP2016527216A (ja) | 2016-09-08 |
AP2016009025A0 (en) | 2016-02-29 |
US20160159789A1 (en) | 2016-06-09 |
EA201690183A1 (ru) | 2016-06-30 |
CU20160003A7 (es) | 2017-02-02 |
TN2016000005A1 (en) | 2017-07-05 |
CA2917380A1 (en) | 2015-01-15 |
SG11201510391VA (en) | 2016-01-28 |
IL243273A0 (en) | 2016-02-29 |
CN105531279A (zh) | 2016-04-27 |
CL2016000038A1 (es) | 2016-07-29 |
WO2015004024A1 (en) | 2015-01-15 |
PE20160125A1 (es) | 2016-03-17 |
ZA201600275B (en) | 2019-04-24 |
KR20160030239A (ko) | 2016-03-16 |
AU2014289415A1 (en) | 2016-01-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12021550792A1 (en) | 2-(morpholin-4-yl)-1,7-naphthyridines | |
MY185139A (en) | Substituted imidazopyridazines | |
MY168413A (en) | Amino-substituted imidazopyridazines | |
PH12017501079A1 (en) | 1,3-thiazol-2-yl substituted benzamides | |
PH12017501133A1 (en) | Pyrazolopyridinamines | |
PH12016501581A1 (en) | Benzimidazol-2-amines as midh1 inhibitors | |
PH12016500054A1 (en) | Substituted pyrazolo-pyridinamines | |
TN2015000371A1 (en) | Substituted imidazopyridazines | |
PH12016501807A1 (en) | Novel compounds | |
UY35040A (es) | Pirrolopirimidinilamino-benzotiazolonas sustituidas | |
PH12016500931A1 (en) | Thienopyrimidines as mknk1 and mknk2 inhibitors | |
WO2014147182A3 (en) | Substituted n-biphenyl-3-acetylamino-benzamides and n-[3-(acetylamino)phenyl]-biphenyl-carboxamides and their use as inhibitors of the wnt signalling pathway | |
PH12016501814A1 (en) | Inhibitors of the wnt signalling pathways | |
TN2014000091A1 (en) | Amino-substituted imidazopyridazines | |
MA39762A (fr) | Nouveaux composés |