MX2015014892A - Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo. - Google Patents
Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo.Info
- Publication number
- MX2015014892A MX2015014892A MX2015014892A MX2015014892A MX2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A MX 2015014892 A MX2015014892 A MX 2015014892A
- Authority
- MX
- Mexico
- Prior art keywords
- cell
- screening assay
- time
- drug screening
- based drug
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Abstract
La presente invención se refiere a un ensayo de detección de fármacos basado en células que comprende los pasos de: (i) cultivar una población de células en un ambiente de cultivo, (ii) definir por lo menos dos puntos de monitoreo en el tiempo en dependencia de por lo menos uno de los tipos de células, las características fisiológicas de las células, las características fisiológicas del tejido formado, el modo de acción de un principio activo y el ambiente de cultivo, (iii) aplicar principios activos a las células cultivadas por lo menos en un punto de tratamiento en el tiempo, (iv) monitorear el efecto de dicho principio activo en las células o tejidos formados por lo menos a dichos dos puntos de monitoreo en el tiempo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13165419.6A EP2796873A1 (en) | 2013-04-25 | 2013-04-25 | Method for a cell-based drug screening assay and the use thereof |
PCT/EP2014/058152 WO2014173907A1 (en) | 2013-04-25 | 2014-04-22 | Method for a cell-based drug screening assay and the use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015014892A true MX2015014892A (es) | 2016-03-07 |
MX366369B MX366369B (es) | 2019-07-05 |
Family
ID=48326111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015014892A MX366369B (es) | 2013-04-25 | 2014-04-22 | Metodo para un ensayo de deteccion de farmacos basado en celulas y el uso del mismo. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20160077081A1 (es) |
EP (2) | EP2796873A1 (es) |
JP (1) | JP6484219B2 (es) |
KR (1) | KR102255944B1 (es) |
CN (1) | CN105143883B (es) |
AU (1) | AU2014257584B2 (es) |
BR (1) | BR112015026601B1 (es) |
CA (1) | CA2910146C (es) |
ES (1) | ES2729341T3 (es) |
IL (1) | IL242172B (es) |
MX (1) | MX366369B (es) |
RU (1) | RU2702643C2 (es) |
SG (1) | SG11201508611WA (es) |
WO (1) | WO2014173907A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
EP3207123A1 (en) | 2014-10-17 | 2017-08-23 | Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
JP2016136848A (ja) * | 2015-01-26 | 2016-08-04 | 富士フイルム株式会社 | 薬剤の評価方法及び薬剤スクリーニング方法 |
GB201514864D0 (en) * | 2015-08-20 | 2015-10-07 | Insphero Ag | An in vitro 3D cell culture model-based tumor relapse assay |
WO2017192997A1 (en) | 2016-05-05 | 2017-11-09 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
KR101916801B1 (ko) * | 2016-08-12 | 2018-11-08 | 경북대학교 산학협력단 | 3차원 생체 모사 시스템을 이용한 맥락막 혈관신생을 수반하는 질환의 치료제 스크리닝 방법 |
IT201600099380A1 (it) * | 2016-10-04 | 2018-04-04 | Univ Bologna Alma Mater Studiorum | Composizioni, dispositivi e metodi per il controllo in vitro del microambiente chimico in colture cellulari |
SG10202105768WA (en) | 2016-12-05 | 2021-06-29 | Childrens Hospital Med Ct | Colonic organoids and methods of making and using same |
JP7405373B2 (ja) | 2018-10-05 | 2023-12-26 | 国立大学法人東海国立大学機構 | 化学物質のスクリーニング方法、プログラム、制御装置、及び培養観察装置 |
GB201818885D0 (en) * | 2018-11-20 | 2019-01-02 | Precomb Therapeutics Ag | 3d human cancer model-based combinatiorial drug development method |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5728541A (en) * | 1996-07-12 | 1998-03-17 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
JP4198468B2 (ja) * | 2001-04-03 | 2008-12-17 | バイオセプト インコーポレイテッド | 生細胞および有機分子をカプセル封入するための方法およびゲル組成物 |
AU2005253923A1 (en) * | 2004-06-08 | 2005-12-29 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
US20090324596A1 (en) * | 2008-06-30 | 2009-12-31 | The Trustees Of Princeton University | Methods of identifying and treating poor-prognosis cancers |
EP2342317B1 (en) | 2008-09-22 | 2012-12-19 | University Of Zurich Prorektorat Forschung | Hanging drop plate |
US8802702B2 (en) * | 2009-01-15 | 2014-08-12 | The General Hospital Corporation | Compounds for reducing drug resistance and uses thereof |
US20110004414A1 (en) * | 2009-06-06 | 2011-01-06 | Ceetox, Inc. | Method for Predicting Respiratory Toxicity of Compounds |
EP2380920A1 (en) * | 2010-04-22 | 2011-10-26 | QGel SA | Hydrogel precursor formulation and production process thereof |
CN103328626B (zh) * | 2010-10-06 | 2017-02-08 | 中外制药株式会社 | 癌干细胞群及其制备方法 |
JP6028236B2 (ja) * | 2011-09-12 | 2016-11-16 | 国立大学法人 熊本大学 | 物質のスクリーニング方法 |
-
2013
- 2013-04-25 EP EP13165419.6A patent/EP2796873A1/en not_active Withdrawn
-
2014
- 2014-04-22 CA CA2910146A patent/CA2910146C/en active Active
- 2014-04-22 MX MX2015014892A patent/MX366369B/es active IP Right Grant
- 2014-04-22 US US14/786,637 patent/US20160077081A1/en active Pending
- 2014-04-22 AU AU2014257584A patent/AU2014257584B2/en active Active
- 2014-04-22 SG SG11201508611WA patent/SG11201508611WA/en unknown
- 2014-04-22 BR BR112015026601-0A patent/BR112015026601B1/pt active IP Right Grant
- 2014-04-22 WO PCT/EP2014/058152 patent/WO2014173907A1/en active Application Filing
- 2014-04-22 ES ES14718624T patent/ES2729341T3/es active Active
- 2014-04-22 CN CN201480022749.4A patent/CN105143883B/zh active Active
- 2014-04-22 JP JP2016509438A patent/JP6484219B2/ja active Active
- 2014-04-22 RU RU2015150203A patent/RU2702643C2/ru active
- 2014-04-22 EP EP14718624.1A patent/EP2989460B1/en active Active
- 2014-04-22 KR KR1020157033467A patent/KR102255944B1/ko active IP Right Grant
-
2015
- 2015-10-20 IL IL242172A patent/IL242172B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CN105143883B (zh) | 2018-10-23 |
MX366369B (es) | 2019-07-05 |
RU2702643C2 (ru) | 2019-10-09 |
AU2014257584A1 (en) | 2015-11-05 |
BR112015026601B1 (pt) | 2023-11-21 |
EP2989460A1 (en) | 2016-03-02 |
WO2014173907A1 (en) | 2014-10-30 |
RU2015150203A (ru) | 2017-05-31 |
SG11201508611WA (en) | 2015-11-27 |
EP2796873A1 (en) | 2014-10-29 |
JP2016518129A (ja) | 2016-06-23 |
KR102255944B1 (ko) | 2021-05-25 |
CA2910146A1 (en) | 2014-10-30 |
BR112015026601A2 (pt) | 2017-07-25 |
ES2729341T3 (es) | 2019-10-31 |
KR20160003761A (ko) | 2016-01-11 |
US20160077081A1 (en) | 2016-03-17 |
IL242172B (en) | 2019-03-31 |
CN105143883A (zh) | 2015-12-09 |
EP2989460B1 (en) | 2019-03-06 |
AU2014257584B2 (en) | 2020-05-14 |
JP6484219B2 (ja) | 2019-03-13 |
CA2910146C (en) | 2024-04-09 |
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