MX2015010876A - Estra-1,3,5(10),16-tetraeno-3-carboxamidas para la inhibicion de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3). - Google Patents
Estra-1,3,5(10),16-tetraeno-3-carboxamidas para la inhibicion de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3).Info
- Publication number
- MX2015010876A MX2015010876A MX2015010876A MX2015010876A MX2015010876A MX 2015010876 A MX2015010876 A MX 2015010876A MX 2015010876 A MX2015010876 A MX 2015010876A MX 2015010876 A MX2015010876 A MX 2015010876A MX 2015010876 A MX2015010876 A MX 2015010876A
- Authority
- MX
- Mexico
- Prior art keywords
- akr1
- estra
- tetraene
- carboxamides
- inhibition
- Prior art date
Links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
Abstract
Inhibidores de AKR1 C3 de fórmula (I) y procesos para su preparación, uso de los mismos para el tratamiento y/o profilaxis de enfermedades y uso de los mismos para la producción de medicamentos para el tratamiento y/o profilaxis de enfermedades, en especial de trastornos de sangrado y endometriosis. (ver Fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13156125 | 2013-02-21 | ||
PCT/EP2014/053094 WO2014128108A1 (de) | 2013-02-21 | 2014-02-18 | Estra-1,3,5(10),16-tetraen-3-carboxamide zur inhibierung von 17.beta.-hydroxysteroid dehdrogenase (akr1 c3) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015010876A true MX2015010876A (es) | 2015-12-03 |
Family
ID=47748503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015010876A MX2015010876A (es) | 2013-02-21 | 2014-02-18 | Estra-1,3,5(10),16-tetraeno-3-carboxamidas para la inhibicion de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3). |
Country Status (28)
Country | Link |
---|---|
US (1) | US9714266B2 (es) |
EP (1) | EP2958928B1 (es) |
JP (1) | JP6254195B2 (es) |
KR (1) | KR20150118153A (es) |
CN (1) | CN105008382B (es) |
AP (1) | AP3826A (es) |
AR (1) | AR094852A1 (es) |
AU (1) | AU2014220800A1 (es) |
BR (1) | BR112015018071A2 (es) |
CA (1) | CA2901632C (es) |
CL (1) | CL2015002346A1 (es) |
CR (1) | CR20150432A (es) |
CU (1) | CU20150091A7 (es) |
EA (1) | EA201500851A1 (es) |
ES (1) | ES2678993T3 (es) |
GT (1) | GT201500235A (es) |
HK (1) | HK1211592A1 (es) |
IL (1) | IL240191A0 (es) |
MA (1) | MA38349A1 (es) |
MX (1) | MX2015010876A (es) |
NI (1) | NI201500115A (es) |
PE (1) | PE20151754A1 (es) |
PH (1) | PH12015501819A1 (es) |
SG (1) | SG11201505875WA (es) |
TN (1) | TN2015000362A1 (es) |
TW (1) | TWI523862B (es) |
UY (1) | UY35344A (es) |
WO (1) | WO2014128108A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106687471B (zh) * | 2014-09-11 | 2018-10-30 | 拜耳医药股份公司 | 3-氮或者硫取代的雌甾-1,3,5(10),16-四烯akr1c3抑制剂 |
US20200264187A1 (en) * | 2016-01-05 | 2020-08-20 | Hamamatsu Photonics K.K. | Living body observation method and living body observation device |
US10167293B2 (en) | 2016-05-26 | 2019-01-01 | Bayer Pharma Aktiengesellschaft | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones |
CZ307437B6 (cs) | 2016-06-07 | 2018-08-22 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz |
EP3269373A1 (en) | 2016-07-11 | 2018-01-17 | Bayer Pharma Aktiengesellschaft | Low-dosed oral dosage form of an akr1c3 inhibitor for treatment of diseases |
CA3047196A1 (en) | 2016-12-19 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones |
TW201825478A (zh) | 2016-12-19 | 2018-07-16 | 德商拜耳製藥公司 | [4-(苯基磺醯基)哌嗪-1--基](1h-1,2,3-***-4-基)甲酮 |
WO2018114672A1 (en) | 2016-12-19 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | [4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones |
EP3421483A1 (en) | 2017-06-29 | 2019-01-02 | Bayer Pharma Aktiengesellschaft | Novel steroidal 17-beta heteroaryl compounds as inhibitors of akr1c3 |
CN108159056A (zh) * | 2018-02-09 | 2018-06-15 | 上海礼璞生物医药科技有限公司 | 孕激素在制备组蛋白去乙酰化酶抑制剂和气道周围胶原沉积抑制剂药物中的应用及抑制剂 |
CN110693892A (zh) * | 2018-07-09 | 2020-01-17 | 深圳艾欣达伟医药科技有限公司 | 化合物用于制备预防、治疗或改善疼痛的药物的用途 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US5604213A (en) | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
IL122740A (en) | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
BR9809748A (pt) | 1997-04-07 | 2000-06-20 | American Home Prod | Estra-5(10), 7-dienos com atividade estrogênica |
EP1094798A2 (en) * | 1998-03-11 | 2001-05-02 | Endorecherche Inc. | INHIBITORS OF TYPE 5 AND TYPE 3 17beta-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE |
CA2339368A1 (en) * | 1998-08-07 | 2000-02-17 | Endorecherche, Inc. | Inhibitors of type 3 3.alpha.-hydroxysteroid dehydrogenase |
JP2007529426A (ja) | 2004-03-12 | 2007-10-25 | エントレメッド インコーポレイテッド | 抗血管新生薬 |
MX2008011127A (es) | 2006-03-02 | 2008-10-31 | Astellas Pharma Inc | INHIBIDOR DE 17ß HSD TIPO 5. |
CA2671075A1 (en) | 2006-11-30 | 2008-06-05 | Solvay Pharmaceuticals Gmbh | Substituted estratrien derivatives as 17beta hsd inhibitors |
US20080153862A1 (en) | 2006-12-22 | 2008-06-26 | Caterina Bissantz | Spiropiperidine derivatives |
EP2172454A4 (en) | 2007-07-24 | 2010-12-08 | Astellas Pharma Inc | benzimidazole derivative |
WO2009120565A2 (en) | 2008-03-25 | 2009-10-01 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
US20110312916A1 (en) | 2009-02-05 | 2011-12-22 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
US20110160159A1 (en) | 2009-09-15 | 2011-06-30 | John Ryan | Treatment of cancer |
CA2839684C (en) | 2011-07-08 | 2017-03-21 | Fmc Technologies, Inc. | Manifold trailer with multiple articulating arm assemblies |
DE102011083725A1 (de) * | 2011-09-29 | 2013-04-04 | Bayer Pharma AG | Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
EA201500112A1 (ru) | 2012-07-10 | 2015-07-30 | Байер Фарма Акциенгезельшафт | 3-замещенные производные эстра-1,3,5(10),16-тетраена, способы их получения, фармацевтические средства, которые их содержат, и их использование для получения лекарственных средств |
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2014
- 2014-02-18 US US14/770,444 patent/US9714266B2/en not_active Expired - Fee Related
- 2014-02-18 EA EA201500851A patent/EA201500851A1/ru unknown
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