MX2015008971A - Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor. - Google Patents

Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor.

Info

Publication number
MX2015008971A
MX2015008971A MX2015008971A MX2015008971A MX2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A MX 2015008971 A MX2015008971 A MX 2015008971A
Authority
MX
Mexico
Prior art keywords
pyrido
pyrrolo
pyrimidine derivatives
treating pain
autotaxin inhibitors
Prior art date
Application number
MX2015008971A
Other languages
English (en)
Inventor
Bryan Hurst Norman
Lance Allen Pfeifer
Yen Dao
Spencer Brian Jones
Thomas James Beauchamp
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2015008971A publication Critical patent/MX2015008971A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente invención proporciona compuestos de la Fórmula I: donde X es un enlace o CH2; R se selecciona del grupo que consiste enR1 y R2 se selecciona cada uno independientemente del grupo que consiste en CH y N; R3 es H o CH3; R4 es H o CH3; L se selecciona del grupo que consiste en -O(CH2)3-, -C(O)NH(CH2)2-, -CH2C(O)NH(NH(CH2)2-, -(CH2)3N(C(O)CH3)CH2-, -(CH2)2N(C(O)CH3)CH2- , (CH2)2OCH2-, -(CH2)4-, -(CH2)2NHCH2-, -(CH2)3O -, and -CH2O(CH2)2-; una sal farmacéuticamente aceptable de este. Los compuestos de invención son inhibidores de autotaxina. (ver Formulas).
MX2015008971A 2013-01-11 2014-01-07 Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor. MX2015008971A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361751363P 2013-01-11 2013-01-11
US201361777201P 2013-03-12 2013-03-12
PCT/US2014/010400 WO2014110000A1 (en) 2013-01-11 2014-01-07 Pyrido- or pyrrolo-fused pyrimidine derivatives as autotaxin inhibitors for treating pain

Publications (1)

Publication Number Publication Date
MX2015008971A true MX2015008971A (es) 2015-09-28

Family

ID=50031555

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015008971A MX2015008971A (es) 2013-01-11 2014-01-07 Derivados de pirimidina pirido- o pirrolo-fusionados como inhibidores de autotaxina para tratar dolor.

Country Status (13)

Country Link
US (1) US8969555B2 (es)
EP (1) EP2943494B1 (es)
JP (1) JP6285461B2 (es)
KR (1) KR101757997B1 (es)
CN (1) CN104903327B (es)
AU (1) AU2014205642B2 (es)
BR (1) BR112015015812A2 (es)
CA (1) CA2893253C (es)
EA (1) EA025106B1 (es)
ES (1) ES2636248T3 (es)
MX (1) MX2015008971A (es)
TW (1) TWI499591B (es)
WO (1) WO2014110000A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201500356A (zh) * 2013-04-12 2015-01-01 Lilly Co Eli 二氫吡啶并嘧啶化合物
CN105793253B (zh) 2013-11-22 2019-08-23 法玛克亚公司 自分泌运动因子抑制剂化合物
US9051320B1 (en) 2014-08-18 2015-06-09 Pharmakea, Inc. Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
AU2016268250B2 (en) 2015-05-27 2020-08-27 Sabre Therapeutics Llc Autotaxin inhibitors and uses thereof
WO2016197009A1 (en) 2015-06-05 2016-12-08 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
KR101798840B1 (ko) 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
AU2019272377B2 (en) * 2018-05-24 2022-03-10 Guangzhou Henovcom Bioscience Co., Ltd. Heteroaromatic compounds, pharmaceutical compositions and uses thereof
AU2019308231B2 (en) * 2018-07-16 2022-12-22 The Scripps Research Institute Opioid haptens, conjugates, vaccines, and methods of generating antibodies
NZ778087A (en) * 2019-02-01 2024-02-23 Wuhan Humanwell Innovative Drug Res And Development Center Limited Company Pyrrolopyrimidine derivative and use thereof
AU2020342202B2 (en) * 2019-09-06 2023-07-06 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Pyrimidine compound and preparation method therefor
WO2021055612A1 (en) * 2019-09-17 2021-03-25 BIAL-BioTech Investments, Inc. Substituted imidazole carboxamides and their use in the treatment of medical disorders
CN112778334B (zh) * 2019-11-07 2022-04-15 广州市恒诺康医药科技有限公司 芳杂环化合物、其药物组合物及其应用
US20230069174A1 (en) * 2019-12-11 2023-03-02 Sichuan Haisco Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic autotaxin inhibitor, and composition containing same and use thereof
WO2022022570A1 (zh) 2020-07-28 2022-02-03 武汉人福创新药物研发中心有限公司 含氮杂环化合物的盐及其盐的固体形式、药物组合物和用途
CN113999235A (zh) * 2020-07-28 2022-02-01 武汉人福创新药物研发中心有限公司 含氮杂环化合物的固体形式及其药物组合物和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SV2002000205A (es) * 1999-11-01 2002-06-07 Lilly Co Eli Compuestos farmaceuticos ref. x-01095
JPWO2003104230A1 (ja) 2002-06-07 2005-10-06 協和醗酵工業株式会社 二環性ピリミジン誘導体
DE102004020908A1 (de) * 2004-04-28 2005-11-17 Grünenthal GmbH Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen
WO2006119504A2 (en) * 2005-05-04 2006-11-09 Renovis, Inc. Fused heterocyclic compounds, and compositions and uses thereof
CN102216299B (zh) * 2008-12-01 2015-02-11 默克专利有限公司 作为自体毒素抑制剂的2,5-二氨基取代的吡啶并[4,3-d]嘧啶化合物
WO2012009258A2 (en) * 2010-07-13 2012-01-19 Edward Roberts Peptidomimetic galanin receptor modulators
EP2606031B1 (en) 2010-08-20 2017-09-27 Amira Pharmaceuticals, Inc. Autotaxin inhibitors and uses thereof
AR084515A1 (es) * 2010-12-22 2013-05-22 Merz Pharma Gmbh & Co Kgaa Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras
WO2013054185A1 (en) 2011-10-13 2013-04-18 Pfizer, Inc. Pyrimidine and pyridine derivatives useful in therapy
ES2648901T3 (es) * 2011-10-28 2018-01-08 Inhibitaxin Limited Derivados de piridazina útiles en terapia
TW201520219A (zh) * 2013-03-12 2015-06-01 Lilly Co Eli 咪唑並吡啶化合物
TW201500356A (zh) * 2013-04-12 2015-01-01 Lilly Co Eli 二氫吡啶并嘧啶化合物

Also Published As

Publication number Publication date
EA025106B1 (ru) 2016-11-30
AU2014205642B2 (en) 2016-02-25
TW201437209A (zh) 2014-10-01
CN104903327A (zh) 2015-09-09
KR101757997B1 (ko) 2017-07-13
EP2943494B1 (en) 2017-02-22
EA201591098A1 (ru) 2015-11-30
JP2016505010A (ja) 2016-02-18
WO2014110000A1 (en) 2014-07-17
CA2893253C (en) 2017-11-28
JP6285461B2 (ja) 2018-02-28
US20140200231A1 (en) 2014-07-17
TWI499591B (zh) 2015-09-11
US8969555B2 (en) 2015-03-03
KR20150092761A (ko) 2015-08-13
BR112015015812A2 (pt) 2017-07-11
ES2636248T3 (es) 2017-10-05
CN104903327B (zh) 2016-09-07
EP2943494A1 (en) 2015-11-18
CA2893253A1 (en) 2014-07-17
AU2014205642A1 (en) 2015-07-02

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